Visible light and near-infrared-responsive chromophores for drug delivery-on-demand applications

Linsley, Chase S.; Quach, Viola Y.; Agrawal, Gaurav; Hartnett, Elyse; Wu, Benjamin M.

doi:10.1007/s13346-015-0260-0

Cited by 27 publications

(13 citation statements)

References 59 publications

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“…They have found that even high‐power 780 nm diode laser (100 mW cm −2 ) did not kill S. aureus . Combination of blue and red light is found by Guffey et al to be effective against S. aureus and P. aeruginosa . It should be noted that our observation that the 400 nm laser is much more efficient for virus inactivation than the 800 nm laser is consistent with those of Tsen et al .…”

Section: Experimental Results Analysis and Discussionsupporting

confidence: 91%

“…The mechanism of femtosecond laser‐induced virus inactivation is highly wavelength dependent. The wavelength dependence of virus inactivation is also demonstrated in previous studies . In the reported literature, there are many discrepancies between the observed nondestructive or destructive effects caused by similar conditions applied to viruses.…”

Section: Experimental Results Analysis and Discussionsupporting

confidence: 54%

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Accelerated inactivation of M13 bacteriophage using millijoule femtosecond lasers

Berchtikou

Greschner

Tijssen

et al. 2019

Journal of Biophotonics

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Irradiation of femtosecond (fs) pulse lasers in the visible and near-infrared ranges have been proposed as a promising approach for inactivating viruses. However, in order to achieve significant virus inactivation, past works have required relatively long irradiation times (1 hour or longer), even for small volumes. Given its advantages compared with other techniques, there is an urgent need to shorten the time required to inactivate viruses using fs laser technology. In this study, we investigate the inactivation of purified M13 bacteriophage in phosphate-buffered saline with large active volume (1 cm 3 ), and short exposure time (several minutes), using lasers with 20 mJ/pulse energy at various wavelengths (800, 400 nm or both 800 and 400 nm combined). For an exposure time of 15 and 2 minute, the use of a 400 nm wavelength laser results in a high load reduction of 5.8 ± 0.3 and 2.9 ± 0.15, respectively, on the log 10 scale of viability. We show that virus inactivation using the 400 nm laser is much more efficient compared with that using an 800 nm laser, or the simultaneous irradiation of 400 and 800 nm lasers. Higher pathogen inactivation is observed for lasers with shorter pulse duration, whereas at longer pulse durations, the inactivation is reduced. For millijoule-energy fs laser irradiation, the M13 bacteriophage inactivation, via the reduction of the functionality of M13 bacteriophages, is accompanied with relatively small amounts of genetic damage. K E Y W O R D Sfemtosecond laser, inactivation, load reduction, M13 bacteriophage

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Section: Experimental Results Analysis and Discussionsupporting

confidence: 91%

Section: Experimental Results Analysis and Discussionsupporting

confidence: 54%

Accelerated inactivation of M13 bacteriophage using millijoule femtosecond lasers

Berchtikou

Greschner

Tijssen

et al. 2019

Journal of Biophotonics

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“…For instance, the photothermal response of the biocompatible chromophores cardiogreen, methylene blue and riboflavin were shown to rapidly generate heat (<2 min) when irradiated with either NIR or visible light. Further, the triggered release of model protein from NiPAAm hydrogels spiked with cardiogreen was achieved with 2 min of NIR light irradiation every 24 h for 4 days [93]. In another recent study, the photothermal response of lanthanum hexaboride nanostructures that were imbedded in PCL microneedles was used to melt the microneedles for the on-demand transdermal delivery of Dox in vivo (Figure 4) [94,95].…”

Section: Hydrogels and Other Form Factorsmentioning

confidence: 99%

Recent Advances in light-responsive on-demand drug-delivery Systems

2017

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The convergence of wearable sensors and personalized medicine enhance the ability to sense and control the drug composition and dosage, as well as location and timing of administration. To date, numerous stimuli-triggered smart drug-delivery systems have been developed to detect changes in light, pH, temperature, biomolecules, electric field, magnetic field, ultrasound and mechanical forces. This review examines the major advances within the last 5 years for the three most common light-responsive drug delivery-on-demand strategies: photochemical, photoisomerization and photothermal. Examples are highlighted to illustrate progress of each strategy in drug delivery applications, and key limitations are identified to motivate future research to advance this important field.

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“…Excited states of chromophores play an important role in a wide variety of applications, including solar energy capture, photocatalysis, bioluminescence/fluorescence, and electrooptic materials. [1][2][3][4][5][6] Predicting optical spectra and accurately characterizing excited state potential energy surfaces (PESs) affords a deeper understanding of these systems but requires accurate excited state methodologies. Even if an excited state method behaves well in regions of a vertical excitation, further challenges exist in modeling the PES near regions of a conical intersection as the Born-Oppenheimer approximation becomes less valid.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Linear Response Theory, Projected Initial Maximum Overlap Method, and Molecular Dynamics Based Vibronic Spectra: The Case of Methylene Blue

Taka

Gowland

et al. 2021

Preprint

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Simulation of optical spectra is essential to molecular characterization and, in many cases, critical for interpreting experimental spectra. The most common method for simulating vibronic absorption spectra relies on the geometry optimization and computation of normal modes for ground and excited states. In this report, we show that utilization of such a procedure within an adiabatic linear response theory framework may lead to state mixings and a breakdown of the Born-Oppenheimer approximation, resulting in a poor description of absorption spectra. In contrast, computing excited states via a self-consistent eld method in conjunction with a maximum overlap model produces states that are not subject to such mixings. We show that this latter method produces vibronic spectra much more aligned with vertical excitation procedures, such as those computed from a vertical gradient or molecular dynamics trajectory-based approach. For the methylene blue chromophore, we compare vibronic absorption spectra computed with: an adiabatic Hessian approach with linear response theory optimized structures and normal modes, a vertical gradient procedure, the Hessian and normal modes of maximum overlap method optimized structures, and excitation energy time correlation functions generated from a molecular dynamics trajectory. Due to mixing between the bright S1 and dark S2 surfaces near the S1 minimum, computing the adiabatic Hessian with linear response theory time-dependent density functional theory with the B3LYP density functional predicts a large vibronic shoulder for the absorption spectrum that is not present for any of the other methods. Spectral densities are analyzed and we compare the behavior of the key normal mode that in linear response theory strongly couples to the optical excitation while showing S1/ S2 state mixings. Overall, our study provides a note of caution in computing vibronic spectra using the excited state adiabatic Hessian of linear response theory optimized structures and also showcases three alternatives that are not as subject to adiabatic state mixing effects.

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Visible light and near-infrared-responsive chromophores for drug delivery-on-demand applications

Cited by 27 publications

References 59 publications

Accelerated inactivation of M13 bacteriophage using millijoule femtosecond lasers

Accelerated inactivation of M13 bacteriophage using millijoule femtosecond lasers

Recent Advances in light-responsive on-demand drug-delivery Systems

Comparison of Linear Response Theory, Projected Initial Maximum Overlap Method, and Molecular Dynamics Based Vibronic Spectra: The Case of Methylene Blue

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