Visible-Light Bactericidal Effect of Silica Gel-supported Porphyrinatoantimony(V) Catalyst on Legionella Species Occurring in the Living Environmental Fields

Fueda, Yoshiyuki; Hashimoto, Manabu; Nobuhara, Kazunori; Yokoi, Haruhiko; Komiya, Yasuhiro; Shiragami, Tsutomu; Matsumoto, Jin; Kawano, Keiichi; Suzuki, Sen; Yasuda, Masahide

doi:10.4265/bio.10.55

Cited by 10 publications

(14 citation statements)

References 15 publications

(8 reference statements)

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“…The coupling of porphyrin with nanoparticles is also a field of research waiting to take off due to the tremendous progress in the discovery of techniques to create well uniform and defined nanoparticles of various elemental composition, size and shape. An example was immobilizing dihydroxo(tetraphenylporphyrinato)antimony(V) on silica gel to effectively sterilize E. coli and Legionella pneumophila , under visible‐light irradiation. The interplay of the central metallic atom in the porphyrin moiety could also bring about useful benefits.…”

Section: Future Directionmentioning

confidence: 99%

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Gan

Gao

et al. 2016

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The emergence of multidrug resistant bacterium threatens to unravel global healthcare systems, built up over centuries of medical research and development. Current antibiotics have little resistance against this onslaught as bacterium strains can quickly evolve effective defense mechanisms. Fortunately, alternative therapies exist and, at the forefront of research lays the photodynamic inhibition approach mediated by porphyrin based photosensitizers. This review will focus on the development of various porphyrins compounds and their incorporation as small molecules, into polymers, fibers and thin films as practical therapeutic agents, utilizing photodynamic therapy to inhibit a wide spectrum of bacterium. The use of photodynamic therapy of these porphyrin molecules are discussed and evaluated according to their electronic and bulk material effect on different bacterium strains. This review also provides an insight into the general direction and challenges facing porphyrins and derivatives as full-fledged therapeutic agents and what needs to be further done in order to be bestowed their rightful and equal status in modern medicine, similar to the very first antibiotic; penicillin itself. It is hoped that, with this perspective, new paradigms and strategies in the application of porphyrins and derivatives will progressively flourish and lead to advances against disease.

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Section: Future Directionmentioning

confidence: 99%

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Gan

Gao

et al. 2016

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“…On the other hand, photocatalytic treatments have received much attention as an environmentally friendly process to inactivate bacteria in contaminated water. In 2002-2003, our group carried out the photoinactivation of Legionella species occurring in bacteria's natural habitats, such as in cooling towers and public fountains using a use of Sb(tpp)/SiO 2 [18].…”

Section: Photoinactivation Of Legionella Species In Naturally Occurrimentioning

confidence: 99%

“…A phosphate buffer (0.1 M, pH 7.0, 10 mL) containing a cell suspension of L. pneumophila (6.4 × 10 5 CFU/100 mL), and Sb(tpp)/SiO 2 (10 mg) was introduced into the L-type glass tube (length 18 cm, diameter 1.5 cm) and irradiated with a fluorescent lamp [18]. Aliquots (0.1 mL) of the reaction mixture were directly plated on a selective medium for Legionella species, i.e., WYOα agar medium (Eiken Chemicals Co., Ltd, Japan) consisting of glycine (3 g), vancomycin (5 mg), polymixin B (10 6 IU), and amphotericin B (80 mg).…”

Section: Photoinactivation Of L Pneumophilamentioning

confidence: 99%

“…The bactericidal experiment was performed in a cooling tower ( Figure 9A) that was located in a building in Miyazaki city [18]. A cylindrical apparatus (200 mmφ × 500 mm, Figure 9B) Visible-Light Photocatalysis of Carbon-Based Materialsthat consisted of seven fluorescent lamps (18 W, 43 mmφ × 50 cm) and the Sb(tpp)/SiO 2 catalyst (4.0 kg, 0.05 wt% Sb(tpp)) was used.…”

Section: Practical Experiments In a Cooling Towermentioning

confidence: 99%

“…Practical experiments were performed in a public fountain of Miyazaki city ( Figure 11A) that was filled with 13 m 3 of water [18]. Photoinactivation of the fountain was examined using a leaf-type of photoinactivation apparatus (200 mmφ × 50 mm, Figure 11B) containing the Sb(tpp)/SiO 2 catalyst (80 g, 0.05 wt% Sb(tpp)), which operated under sunlight irradiation.…”

Section: Practical Experiments In Water Fountainmentioning

confidence: 99%

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Silica Gel–Supported P-, Ge-, and Sb-Porphyrins for Visible Light Inactivation of Bacteria

Yasuda¹,

Matsumoto²

2018

Visible-Light Photocatalysis of Carbon-Based Materials

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This chapter describes the photocatalysis action of (dihydroxo)tetraphenyl¬porphyrinato complexes of high valent P (V), Ge (IV), and Sb (V) (P(tpp), Ge(tpp), and Sb(tpp)). These chromophores were fixed onto silica gel (SiO2) through Coulombic forces and hydrogen bonding between axial hydroxo ligands and silanol groups to produce M(tpp)/SiO2 (M = P, Ge, and Sb) composites. M(tpp)/SiO2 were applied to the photo-inactivation of Escherichia coli and Legionella pneumophila. Moreover, M(tpp)/SiO2 was subjected to practical experiments for the photoinactivation of L. pneumophila naturally occurring in a cooling tower and a public fountain. It is noteworthy that 80 g of Sb(tpp)/SiO2 catalyst, containing 40 mg of Sb(tpp) maintained a concentration of Legionella species below 100 CFU/100 mL for 120 days in 13 m3 of water in a fountain under sunlight exposure. The photoinactivation proceeded through the liberation of M(tpp) from SiO2, adsorption of M(tpp) inside bacteria, and generation of reactive oxygen species, such as singlet oxygen, under visible light irradiation, thus resulting in bacteria apoptosis. Based on these results, we developed water-soluble porphyrins by modification of P and Sb porphyrin axial ligands to alkyloxo, alkylethylenedioxy, and alkylpyridinium groups. These water-soluble porphyrins were applied to the photodynamic inactivation of E. coli and Saccharomyces cerevisiae.

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Antimony porphyrin complexes as visible-light driven photocatalyst

Shiragami

Matsumoto

Inoue

et al. 2005

Journal of Photochemistry and Photobiology C: Photochemistry Re

105

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Visible-Light Bactericidal Effect of Silica Gel-supported Porphyrinatoantimony(V) Catalyst on Legionella Species Occurring in the Living Environmental Fields

Cited by 10 publications

References 15 publications

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

A Perspective on the Trends and Challenges Facing Porphyrin‐Based Anti‐Microbial Materials

Silica Gel–Supported P-, Ge-, and Sb-Porphyrins for Visible Light Inactivation of Bacteria

Antimony porphyrin complexes as visible-light driven photocatalyst

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