Visible-light degradable polymer coated hollow mesoporous silica nanoparticles for controlled drug release and cell imaging

Abstract

A core-shell nanocomposite based on photo-degradable polymer coated hollow mesoporous silica nanoparticles (HMS) was successfully prepared for targeted drug delivery and visible-light triggered release, as well as fluorescence cell imaging. The HMS nanoparticles were first modified by the longchain hydrocarbon octadecyltrimethoxysilane (C18) and fluorescent agent Rhodamine B isothiocyanate (RITC), and then encapsulated by a photodegradable amphiphilic copolymer via a self-assembly process.The obtained nanocarrier showed a high drug loading content due to the hollow core and mesopores of the HMS and could target folic acid receptor over-expressed tumor cells efficiently for conjugating folic acid (FA) in the amphiphilic polymer. The drug release could be triggered by the irradiation of green light (500-540 nm) due to the photodegradation of amphiphilic copolymer coated on the HMS. Furthermore, the targeted drug delivery and controlled release processes could be tracked by fluorescence imaging for the doping of RITC on the HMS. The In vitro results suggested that a smart visible light responsive drug delivery system was successfully prepared for the potential applications of cancer diagnosis and therapy.

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

“…The photolysis involved in the phototransformation of dialkoxyanthracene submitted to singlet oxygen was also applied for the design of light‐responsive silica nanocarriers. Using MSNs coated with photodegradable amphiphilic copolymers bearing photocleavable 9,10‐dialkoxyanthracene moieties, the release and the delivery of doxorubicin were reported . Upon green light exposure (540 nm), the photolysis of 9,10‐dialkoxyanthracene moieties lead to the formation of 9,10‐anthraquinone due to the singlet oxygen production of eosin Y mixed in the reaction media.…”

Low-cost photo-responsive nanocarriers by one-step functionalization of flame-made titania agglomerates withl-Lysine

“…1 For example, key anti-cancer drugs, such as paclitaxel and docetaxel, which used to be difficult to deliver due to their hydrophobic nature, 2 are now supplied with the aid of substrates such as noble metals, 3 metal oxides, 4 polymers, 5 and solid lipids. 8 The release of drugs and other functional molecules may occur passively by diffusion, as a response to changes in pH, 9 progressive degradation of the substrate material, 10 and temperature change, 11 or actively such as by magnetic and ultrasonic resonance 12 and photocleavage. 8 The release of drugs and other functional molecules may occur passively by diffusion, as a response to changes in pH, 9 progressive degradation of the substrate material, 10 and temperature change, 11 or actively such as by magnetic and ultrasonic resonance 12 and photocleavage.…”

Hollow Mesoporous Functional Hybrid Materials: Fascinating Platforms for Advanced Applications

“…A core–shell nanocomposite based on photodegradable polymer‐coated hollow mesoporous silica nanoparticles (HMSNs) can be applied for targeted drug delivery and visible‐light triggered release as well as for fluorescence cell imaging . Polymeric vesicles supplemented with pH‐responsive outlayered gels were developed as a delivery system for doxorubicin using chitosan and poly(γ‐glutamic acid) …”