Visible‐Light‐Driven Photocatalysis‐Enhanced Nanozyme of TiO₂ Nanotubes@MoS₂ Nanoflowers for Efficient Wound Healing Infected with Multidrug‐Resistant Bacteria

Abstract

To enhance the catalytic activity of the nanozymes for efficient wound healing infected with multidrug‐resistant bacteria, photo‐based motivations have been suggested, but attention is mainly focused on the external stimulus of near‐infrared light, while the inexhaustible visible one is promising but lack of study. Herein, an efficient visible light‐stimulated peroxidase‐like nanozyme system, TiO2 nanotubes coated with MoS2 nanoflowers (TiO2NTs@MoS2), is discovered for efficient bacterial treatment. Based on the synergetic effects between the two components, the bandgap of the TiO2NTs can be narrowed from 3.2 to 2.97 eV due to the MoS2 loading, which extended the light response of TiO2 to visible‐light range and enhanced the photocatalytic activity accordingly. Meanwhile, the peroxidase‐like activity of MoS2 can be significantly enhanced due to the combination with TiO2NTs in return. Especially, the peroxidase‐like activity of the TiO2NTs@MoS2 nanocomposite can be further improved under the sunlight irradiation, rendering much more hydroxyl radical (•OH) generation. Accordingly, the as‐obtained TiO2NTs@MoS2 shows an outstanding antibacterial effect against drug‐resistance extended spectrum β‐lactamases producing Escherichia coli and methicillin‐resistant Staphylococcus aureus under the visible light. In vivo wound healing test further confirms the high antimicrobial efficiency and good biocompatibility of the synergistic antimicrobial system.

Photothermal Regulated Nanozyme of CuFeS2 Nanoparticles for Efficiently Promoting Wound Healing Infected by Multidrug Resistant Bacteria

“…Some inorganic nanomaterials with peroxidase-like activity have been reported, such as V 2 O 5 QDs, Au NPs, and MoS 2 nanomaterials, etc. [ 3 , 11 ]. Although these nanomaterials have shown great potential for antimicrobial use in peroxidase-mediated chemokinetic therapy (CDT), their antibacterial effects are limited, due to the insufficient production of hydroxyl radicals (•OH) and short effective action distance of hydroxyl radicals [ 12 ].…”

Efficient nanozyme engineering for antibacterial therapy

“…Similarly, Chen's work also demonstrated visible light illumination improved ROS generation for MoS 2 /rGO VHS, thereby resulting in high bactericidal efficiency and wound healing promotion with the assistant of H 2 O 2 and light [81]. A TiO 2 NTs@MoS 2 nanozyme composed of TiO 2 nanotubes coated with MoS 2 nanoflowers was also reported to display visible light-stimulated enhancement in the POD-like activity of MoS 2 due to the combination with the semiconductor TiO 2 NTs [45]. Accordingly, the as-obtained TiO 2 NTs@MoS 2 could produce much more •OH, showing outstanding antibacterial effect against drug-resistant bacteria under the visible light and excellent wound healing efficacy.…”

“…Au [19][20][21][22][23][24][25][26], Pt [27], Cu [28], Ir [29], Ag [30], Au-Pt [31,32], Pd-Cu [33], Pd-Pt [34], Au-Ag [35], etc), transition metal oxide or sulfide (e.g. Fe 3 O 4 [36][37][38], CuO [39], CeO 2 [40], V 2 O 5 [41], Co-V mixed metal oxide (MMO) [42], MoS 2 [43][44][45][46][47], NiS 2 [48], CuS [49][50][51][52], Co 4 S 3 [53], MnO 2 [54] etc), and nanocarbon (e.g. boron doped graphdiyne (B-GDY) [8], N-doped sponge-like carbon spheres (N-SCSs) [55], graphene quantum dots [56,57], etc)-based nanozymes, to recentlyadvanced metal organic framework (MOF) (e.g.…”

AIEgen Intercalated Nanoclay-Based Photodynamic/Chemodynamic Theranostic Platform for Ultra-Efficient Bacterial Eradication and Fast Wound Healing

“…Bacterial infection was one of the biggest threats to human health before the 1940s, which could cause terrible diseases, such as sepsis, tetanus, bubonic plague, tuberculosis, diphtheria, syphilis, typhus, and many more. − Although antibiotics have fought an impressive battle against bacterial infections, the threat has not been completely erased. The overuse and indiscriminate use of antibiotics brings about the emergence of antibiotic resistance, making a growing number of infections harder to treat. − Therefore, alternative therapeutic strategies with highly antibacterial efficacy and low tendency to induce drug resistance are strongly desired to combat the severe resistance problems.…”