Visible Light‐Enabled Decarboxylative Alkylation of Quinoxalin‐2(1H)‐ones using Alkyl Carboxylic Acids via Energy Transfer Process

Abstract

Here in, we describe the photochemical decarboxylative alkylation of quinoxalin‐2(1H)‐ones using commercially accessible carboxylic acids with oxygen as sole oxidant through energy transfer process. The coupling of diverse array of alkyl carboxylic acids (1o to 3o) and bioactive acids with quinoxalin‐2(1H)‐ones is successfully accomplished to achieve the desired alkylated products.

Visible Light-Induced Electron–Donor–Acceptor-Mediated C-3 Coupling of Quinoxalin-2(1H)-ones with Unactivated Aryl Iodides

“…Based on the control experiments and literature precedents, ,, a tentative reaction mechanism has been proposed in Scheme . Quinoxalin-2­(1 H )-one ( 1a ) and K 3 PO 4 form a colored EDA complex ( 1 ); additionally, aryl halide ( 2a ) with dimsyl anion also forms a light colored EDA complex ( 2 ) with a small hump with respect to EDA ( 1 ), which upon photoexcitation is followed by a single electron transfer (SET) process to give the radical ion pairs ( a ) and ( b ).…”