Visible-light induced cross-electrophile coupling of imines and anhydrides to synthesize α-amino ketones

Abstract

α-Amino ketones are important motifs in synthetic and medicinal chemistry. Efficient methods to direct access these motifs from feasible precursors are, however, limiting. Herein, a visible-light-mediated reductive cross-electrophile coupling of...

Photoredox-catalyzed intramolecular oxy- and aminoacylation of alkenes with acyl oxime esters: facile synthesis of acylated saturated heterocycles

“…4 In this regard, in particular, the acyl radical-triggered transformation has emerged as a hot research topic due to the potential derivatization applications of the acyl substituent in heterocyclic compounds. 5 To date, several common carbonyl compounds including aromatic aldehydes, 6 carboxylic acids, 7 anhydrides, 8 acyl chlorides, 9 α-ketocarboxylic acids, 10 and other acyl sources 11 have been widely utilized in a series of acyl-radical-involved transformations. Notably, Xu, 12 Li, 13 and other groups 14 successfully developed the acyl radical-driven cyclization reaction of alkenes towards acyl-containing heterocycles.…”