Visible-Light-Induced Domino Cyclization to Access Pyri-do[2,3-d]pyrimidine-2,4-diones via a Radical-Polar Crossover Reaction

Abstract

Catalytic and green strategies for the synthesis of privileged scaffolds are synthetically appealing. We now reported a radical-polar crossover (RPC)-enabled three-component cyclization of bromodifluoroalkyls with enaminones and 6-aminouraciles via a visible-light-induced dom-ino cyclization. The reaction exhibited a broad substrate scope (> 40 examples) including complex molecules, which highlighted the utility of this strategy for the construction of a library of bioactive analogs.