Visible Light-Induced Healing of Diabetic or Venous Foot Ulcers: A Placebo-Controlled Double-Blind Study

Landau, Zvi; Migdal, Michal; Lipovsky, Anat; Lubart, Rachel

doi:10.1089/pho.2010.2858

Cited by 55 publications

(44 citation statements)

References 21 publications

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“…At the end of the follow up, all of the wounds in 9 of the treatment group patients were closed (90%) whereas in the placebo group, only 2 of 6 patients (33%) had closed wounds, judged by Wagner's classification for foot ulcer and wide/length measurement. There were no adverse therapy effects [20]. …”

Section: Resultsmentioning

confidence: 99%

Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey

Beckmann

Meyer-Hamme

Schröder

2014

Evidence-Based Complementary and Alternative Medicine

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Diabetic foot ulcers as one of the most common complications of diabetes mellitus are defined as nonhealing or long-lasting chronic skin ulcers in diabetic patients. Multidisciplinary care for the diabetic foot is common, but treatment results are often unsatisfactory. Low level laser therapy (LLLT) on wound areas as well as on acupuncture points, as a noninvasive, pain-free method with minor side effects, has been considered as a possible treatment option for the diabetic foot syndrome. A systematic literature review identified 1764 articles on this topic. Finally, we adopted 22 eligible references; 8 of them were cell studies, 6 were animal studies, and 8 were clinical trials. Cell studies and animal studies gave evidence of cellular migration, viability, and proliferation of fibroblast cells, quicker reepithelization and reformed connective tissue, enhancement of microcirculation, and anti-inflammatory effects by inhibition of prostaglandine, interleukin, and cytokine as well as direct antibacterial effects by induction of reactive oxygen species (ROS). The transferral of these data into clinical medicine is under debate. The majority of clinical studies show a potential benefit of LLLT in wound healing of diabetic ulcers. But there are a lot of aspects in these studies limiting final evidence about the actual output of this kind of treatment method. In summary, all studies give enough evidence to continue research on laser therapy for diabetic ulcers, but clinical trials using human models do not provide sufficient evidence to establish the usefulness of LLLT as an effective tool in wound care regimes at present. Further well designed research trials are required to determine the true value of LLLT in routine wound care.

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Section: Resultsmentioning

confidence: 99%

Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey

Beckmann

Meyer-Hamme

Schröder

2014

Evidence-Based Complementary and Alternative Medicine

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“…[24][25][26][27] Specifically, a PBM approach has shown promising efficacy in VLU treatment. [28][29][30] The photo-converter wound gel is presented in two jars, which have to be mixed together just prior to application. Typically, upon evaluation, any excess fibrin or necrotic tissue was debrided.…”

mentioning

confidence: 99%

A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers

Nikolis¹,

Grimard²,

Pesant³

et al. 2016

CWCMR

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Purpose: To investigate the safety and efficacy of the BioPhotonic System developed by Klox Technologies in a case series of ten patients with venous leg ulcers. Patients and methods: Ten patients with chronic venous leg ulcers, having failed on at least one previous therapy, were enrolled into this case series. Results: Nine patients were evaluable for efficacy. A response (defined as decrease in wound surface area) was observed in seven patients (77.8%). Of these, four patients (44.4%) achieved wound closure on average 4 months (127.5 days) following the beginning of the treatment. Two patients did not respond to the investigational treatment. Quality of life improved over time throughout the study. Compliance was excellent, with 93.2% of visits completed as per protocol. Safety was unremarkable, with only four treatment-emergent-related adverse events, for which no specific intervention was required. Conclusion: The BioPhotonic System was shown to be safe and extremely well tolerated. It also demonstrated potential in terms of wound closure, wound surface area decrease, and wound bed preparation.

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“…Landau Z et al, demonstrated effects of hyperbaric oxygen along with laser. 13 Treatment time was 20mins for 2-3weeks. 81% of refractory diabetic foot ulcers were healed by this method.…”

Section: Discussionmentioning

confidence: 99%

Low level red laser therapy using wavelength 635nm for diabetic foot ulcers: a prospective study

2019

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Background: Diabetic foot ulcer is one of the important complications of diabetes. After effective debridement and antibiotic therapy, lasers are used to hasten the healing process. Red laser of wavelength 635nm promotes wound healing. This study will aid us to find out the efficacy of red laser wavelength 635nm in healing of diabetic foot ulcers.Methods: After obtaining informed consent, diabetic foot ulcer patients admitted to Rajiv Gandhi government hospital were selected based on non-probability convenience sampling. Necessary history obtained, clinical examination of the ulcer done, investigations done. Cases are given 30minutes of laser therapy by non-contact method before regular ulcer dressing. Controls are given saline dressing. Ulcer area measured before initiation of therapy and measured at 1st week, 2nd week and 3rd week after initiation of therapy.Results: Wound contraction rate was 39.65% with laser and 11.26% with saline dressing alone (p<0.001). The data were statistically significant; thus, laser have wound healing property.Conclusions: Cases have more mean contraction percentage than controls (37.99% versus 11.68%, p<0.001). So LLLT is an effective therapy to heal diabetic ulcers. Need for additional surgeries can be avoided by using LLLT.

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Visible Light-Induced Healing of Diabetic or Venous Foot Ulcers: A Placebo-Controlled Double-Blind Study

Abstract: In this small scale placebo-controlled double-blind study, broadband (400-800 nm) visible light was an effective modality for the treatment of leg or foot ulcers.

Cited by 55 publications

References 21 publications

Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey

Low Level Laser Therapy for the Treatment of Diabetic Foot Ulcers: A Critical Survey

A prospective case series evaluating the safety and efficacy of the Klox BioPhotonic System in venous leg ulcers

Low level red laser therapy using wavelength 635nm for diabetic foot ulcers: a prospective study

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