Visible-light induced one-pot hydrogenation and amidation of nitroaromatics with carboxylic acids over 2D MXene-derived Pt/N-TiO2/Ti3C2

Green and sustainable visible light-mediated formation of amide bonds: an emerging niche in organic chemistry

“…During the same time, a visible light-driven amidation reaction of nitroarenes 20 and acetic acids 13 was accomplished by Bian and co-workers (Scheme 35). 97 Nitroarenes with both electron-deficient groups (Cl, COMe, CHO) and electron-rich groups (Me, OMe) performed well to give the respective amides in good yields. Under the reaction system, nitroarene 20 is hydrogenated to give the in situ amine 27 , which reacts with acetic acid 13 , leading to the desired amide 81 .…”

Iodine-Promoted Transamidation of N,N-Dimethylacetamide (DMA) with Amines

“…Among these methods, the simplest and attractive procedure is the transamidation process of N,N-dimethylacetamide (DMA) with amines. Several catalysts have been used in transamidation reaction, such as Pd, [10] Ni, [11] Cu, 12] Zn, [13] Fe, [14] Al, [15] Ti, [16] Au, [17] Ru, [18] Zr, [19] Mn, [20] sulfated Figure 1 Acetamides structural units in some drug molecules tungstate, [21] H 2 SO 4 SiO 2 , [22] molybdate sulfuric acid [23] , hydroxylamine hydrochloride, [24] L-proline, and benzotriazole. [25] In 2017, Jagtap's group [26] developed a Ni(quin) 2 catalyst in homogeneous medium for N-acetylation of amines in the presence of imidazole (Scheme 1, a).…”

An Environmentally Benign, Catalyst‐Free N−C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

“…However, due to the amide bond‘s stability, various catalysts or activating agents are used for the transamidation of amines [6] . Several transition‐metal based catalytic systems employed in the transamidation reactions viz : Pd, [7a] Ni [7b] (Scheme 1B), Fe, [7c] Cu, [7d] Mn, [7e] lanthanides, [8a] Ti, [8b] Zr, [8c] Al, [8d] and sulfated tungstate [8e] are widely used in academia and industry for the preparation of amides [9] . Additionally, metal‐catalysed reactions are undesirable due to waste metal and increasing synthetic costs.…”