“…Barbier-type allylation has been the traditional approach to the synthesis of trifluoromethyl-and allylsubstituted tert-alcohols (Guo et al, 2017;Nie et al, 2011;Tordeux et al, 1990). The Barbier process involves the introduction of metal complexes, such as indium (Araki et al, 1988;Loh et al, 1999;Roy and Roy, 2010;Shen et al, 2013), zinc (Grellepois et al, 2017;Metzger et al, 2010;Yin et al, 2020), ruthenium (Cicco et al, 2017;Wang et al, 2017Wang et al, , 2021, titanium (Li et al, 2020), or mercury (Cao et al, 2016;Gong et al, 2019), into the carbon-halide/carbon-silyl bond for generating the reactive nucleophilic allylmetal intermediates, which react with the trifluoromethyl ketone to furnish the trifluoromethyl-and allyl-substituted tert-alcohol (Figure 1a). Despite these advantages, the Barbier reaction requires stoichiometric amounts of metals, and catalytic approaches are limited to the use of allylboron/allylsilane reagents that are difficult to prepare.…”