Visible-light-mediated decarboxylative alkylation of 2-pyridone derivatives via a C3-selective C–H functionalization

Abstract

A direct C–H functionalization approach to access C3-alkylated 2-pyridone derivatives is reported. This study utilizes N-hydroxyphthalimide (NHPI) esters of various carboxylic acids as sources for alkyl radicals by reductive cleavage...

Photoinduced cobalt catalyzed site selective alkylation of 2-pyridones

“…5 Yamakawa et al reported for the first time diverse highly reactive alkylating reagents for the C3-selective radical C–H trifluoromethylation 6 of 2-pyridone, including α-bromo carbonyl, 7 2-substituted diethyl malonates, 8 xanthate, 9 and NHPI esters. 10 Due to the highest electron deficiency at the C6 position of the 2-pyridone ring, achieving selective C–H functionalization at this site requires different strategies compared to those for other positions. Nakao and Hiyama successfully achieved direct C6-selective alkylation with unactivated alkenes using Ni/Al cooperative catalysis.…”