Visible-light-mediated direct C3 alkylation of quinoxalin-2(1H)-ones using alkanes

Abstract

Due to the high C–H bond dissociation energy of alkanes, the utilization of alkanes as alkyl radical precursors for C–H functionalization of heteroarenes is synthetically captivating but practically challenging especially...

Organophotoelectrocatalytic C(sp2)–H alkylation of heteroarenes with unactivated C(sp3)–H compounds

“…In addition to these methods, the dehydrogenation cross-coupling of heteroarenes with C(sp 3 )–H compounds offers an appealing alternative for achieving C(sp 2 )–H alkylation of heteroarenes. 11 C(sp 3 )–H compounds are highly competitive and attractive alkylating reagents due to their stability, ready availability, and low cost. However, metal reagents and stoichiometric oxidants are often required to achieve above Minisci-type alkylation (Scheme 1a).…”