Visible light plasmon excitation of silver nanoparticles against antibiotic-resistant Pseudomonas aeruginosa

Silva, Rafael T. P. da; Petri, Marcos V.; Valencia, Estela Y.; Camargo, Pedro Henrique Cury de; Torresi, Susana Inês Córdoba de; Spira, Beny

doi:10.1016/j.pdpdt.2020.101908

Cited by 25 publications

(15 citation statements)

References 82 publications

(64 reference statements)

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“…According to this experiment, it seems that AgNPs, which have antibacterial effects against P. aeruginosa, were enhanced by the formation of ROS via LSPR. Moreover, the release of Ag + occurred several hours after AgNPs had already killed the bacteria [81].…”

Section: Results Of the Literature Searchmentioning

confidence: 99%

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

et al. 2022

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The emergence of multidrug-resistant (MDR) bacteria in recent years has been alarming and represents a major public health problem. The development of effective antimicrobial agents remains a key challenge. Nanotechnologies have provided opportunities for the use of nanomaterials as components in the development of antibacterial agents. Indeed, metal-based nanoparticles (NPs) show an effective role in targeting and killing bacteria via different mechanisms, such as attraction to the bacterial surface, destabilization of the bacterial cell wall and membrane, and the induction of a toxic mechanism mediated by a burst of oxidative stress (e.g., the production of reactive oxygen species (ROS)). Considering the lack of new antimicrobial drugs with novel mechanisms of action, the induction of oxidative stress represents a valuable and powerful antimicrobial strategy to fight MDR bacteria. Consequently, it is of particular interest to determine and precisely characterize whether NPs are able to induce oxidative stress in such bacteria. This highlights the particular interest that NPs represent for the development of future antibacterial drugs. Therefore, this review aims to provide an update on the latest advances in research focusing on the study and characterization of the induction of oxidative-stress-mediated antimicrobial mechanisms by metal-based NPs.

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Section: Results Of the Literature Searchmentioning

confidence: 99%

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

et al. 2022

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“…Regarding their antibacterial role, once the AgNPs are in contact with bacteria, the free radical-mediated pore generation into the cell wall is the leading mechanism of bacterial cell death. Therefore, some authors have investigated how to improve the AgNPs' antimicrobial activity via localized surface plasmon resonance (LSPR) to increase the ROS generation by exposure to visible light [80].…”

Section: Silver Npsmentioning

confidence: 99%

“…The main objective of this study was to increase the antibacterial activity of AgNPs by exploiting the capability of LSPR to influence the electronic state of the particles and increase the number of silver ions (Ag + ) which ultimately are responsible for the antimicrobial effect. Recently, research from da Silva and colleagues [80] has shown a link among AgNPs, LSPR, ROS and the AgNPs' antimicrobial activity. The authors claim that, even if some studies support the idea that Ag + plays a main role in antibacterial activity [83], together with the capability of AgNPs to introduce nicks in the cytoplasmic membrane [84], AgNPs and Ag + can also induce ROS formation, which damages the cell cytoskeleton, oxidizing nucleic acids and proteins, leading to potential chromosomal aberrations and cell death [85].…”

Section: Silver Npsmentioning

confidence: 99%

Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles

et al. 2020

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The design, synthesis and characterization of new nanomaterials represents one of the most dynamic and transversal aspects of nanotechnology applications in the biomedical field. New synthetic and engineering improvements allow the design of a wide range of biocompatible nanostructured materials (NSMs) and nanoparticles (NPs) which, with or without additional chemical and/or biomolecular surface modifications, are more frequently employed in applications for successful diagnostic, drug delivery and therapeutic procedures. Metal-based nanoparticles (MNPs) including metal NPs, metal oxide NPs, quantum dots (QDs) and magnetic NPs, thanks to their physical and chemical properties have gained much traction for their functional use in biomedicine. In this review it is highlighted how the generation of reactive oxygen species (ROS), which in many respects could be considered a negative aspect of the interaction of MNPs with biological matter, may be a surprising nanotechnology weapon. From the exchange of knowledge between branches such as materials science, nanotechnology, engineering, biochemistry and medicine, researchers and clinicians are setting and standardizing treatments by tuning ROS production to induce cancer or microbial cell death.

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“…However, the ROS-mediated cytotoxicity was more evident in the case of Gram-negative bacterium [181]. Light-irradiated enhanced bactericidal effects were also reported for P. aeruginosa treated with citrate-coated nanoparticles [182].…”

Section: Silver Nanoparticles For Antibacterial Applicationsmentioning

confidence: 76%

An Updated Review on Silver Nanoparticles in Biomedicine

et al. 2020

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Silver nanoparticles (AgNPs) represent one of the most explored categories of nanomaterials for new and improved biomaterials and biotechnologies, with impressive use in the pharmaceutical and cosmetic industry, anti-infective therapy and wound care, food and the textile industry. Their extensive and versatile applicability relies on the genuine and easy-tunable properties of nanosilver, including remarkable physicochemical behavior, exceptional antimicrobial efficiency, anti-inflammatory action and antitumor activity. Besides commercially available and clinically safe AgNPs-based products, a substantial number of recent studies assessed the applicability of nanosilver as therapeutic agents in augmented and alternative strategies for cancer therapy, sensing and diagnosis platforms, restorative and regenerative biomaterials. Given the beneficial interactions of AgNPs with living structures and their nontoxic effects on healthy human cells, they represent an accurate candidate for various biomedical products. In the present review, the most important and recent applications of AgNPs in biomedical products and biomedicine are considered.

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Visible light plasmon excitation of silver nanoparticles against antibiotic-resistant Pseudomonas aeruginosa

Cited by 25 publications

References 82 publications

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

Current Knowledge on the Oxidative-Stress-Mediated Antimicrobial Properties of Metal-Based Nanoparticles

Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles

An Updated Review on Silver Nanoparticles in Biomedicine

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