Visible spectrophotometric estimation of aceclofenac and indapamide from tablets using folin-ciocalteu reagent

A rapid microtitre plate Folin-Ciocalteu method for the assessment of polyphenols

“…Originally this method was developed for the colorimetric determination of tyrosine, a phenolic nonessential amino acid [4]. Thereafter, this method has been used for the determination of several compounds including plant phenolics, drugs [5][6][7], vitamin C [8] and other constituents in a wide range of samples ranging from plant extracts to urine and bee products, in particular. The spectrophotometer-cuvette method is also frequently quoted.…”

Evaluation of Tropaeolin 000-1 as a Colorimetric Reagent for Assay of Duloxetine and Escitalopram in Solid Dosage Form

“…The maximum wavelength that can be used to examine such drugs with methyl orange and bromocresol green ranges from 410 to 415 nm, and these compounds experience interference with material that have UV absorption, such as certain preservatives and diluents present in solid dosage forms. Other commonly used colorimetric reagents require specific functional groups such as primary amine, phenolic, and aldehydic groups, which makes methods that use them more laborious than extractive colorimetric procedures [1][2][3][4].…”

RP-HPLC analysis for the simultaneous estimation of rabeprazole sodium and aceclofenac in a combined dosage form

“…Aceclofenac directly blocks prostaglandin (PGE2) secretion at the site of inflammation by inhibiting interleukin (IL1) and tumour necrosis factor (TNF) in the inflammatory cells (intracellular action) . Literature review reveals that Spectrophotometric (Kousy et al, 1999;Zawilla et al,2002;Rahman et al, 2008;ElGindy et al, 2003;Shah et al, 2008;Mishra et al, 2006) HPLC (Singhvi et al, 2007;Park et al, 2008;Ramakrishna et al, 2005;Srinivas et al, 2009;Uno et al, 2005;Singh et al, 2004;Rao et al, 2006;Kulkarni et al, 2006;Jin et al, 2006;Bhinge et al, 2008;Hinz et al, 2006;Musmade et al, 2008) and HPTLC (Joshi et al, 2008) methods have been reported for estimation of individual drugs or in combination with other drugs in formulation. So far no simultaneous method has been reported as this was a new combined dosage form.…”