Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Weinstain, Roy; Slanina, Tomáš; Kand, Dnyaneshwar; Klán, Petr

doi:10.1021/acs.chemrev.0c00663

Cited by 426 publications

(500 citation statements)

References 1,802 publications

(3,807 reference statements)

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“…One CO delivery strategy is based on metal carbonyl complexes that release a weakly bound CO by simple hydrolytic ligand exchange upon dissolution in aqueous media [22,23]. Another approach is the use of photochemically activatable CO-releasing molecules (photoCORMs), which allow precise spatial and temporal control over its release in tissues [24][25][26][27][28]. Visible/NIR light has a reduced tissue penetration due to high optical scattering and strong absorbance by endogenous chromophores, such as hemoglobin or melanin [29,30]; therefore, photo-CORMs activatable in this wavelength range are highly desirable.…”

Section: Introductionmentioning

confidence: 99%

Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives

et al. 2021

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Carbon monoxide (CO) is an endogenously produced signaling molecule involved in the control of a vast array of physiological processes. One of the strategies to administer therapeutic amounts of CO is the precise spatial and temporal control over its release from photoactivatable CO-releasing molecules (photoCORMs). Here we present the synthesis and photophysical and photochemical properties of a small library of meso-carboxy BODIPY derivatives bearing different substituents at positions 2 and 6. We show that the nature of substituents has a major impact on both their photophysics and the efficiency of CO photorelease. CO was found to be efficiently released from π-extended 2,6-arylethynyl BODIPY derivatives possessing absorption spectra shifted to a more biologically desirable wavelength range. Selected photoCORMs were subjected to in vitro experiments that did not reveal any serious toxic effects, suggesting their potential for further biological research.

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Section: Introductionmentioning

confidence: 99%

Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives

et al. 2021

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“…The specific characteristics of light that allow for the manipulation of antimicrobial properties of photoresponsive drugs represent valuable means to tackle MDR-associated issues. Recent research introduced photoswitchable antibacterial agent analogs, revealing their selective on/off "light switching" behavior [101][102][103][104].…”

Section: Terrestrial Microbial Concerns: Approaches For Multiple Drug Resistancementioning

confidence: 99%

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

et al. 2021

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The evolution of different antimicrobial drugs in terrestrial, microgravity and hypergravity conditions is presented within this review, in connection with their implementation during human space exploration. Drug stability is of utmost importance for applications in outer space. Instabilities may be radiation-induced or micro-/hypergravity produced. The antimicrobial agents used in space may have diminished effects not only due to the microgravity-induced weakened immune response of astronauts, but also due to the gravity and radiation-altered pathogens. In this context, the paper provides schemes and procedures to find reliable ways of fighting multiple drug resistance acquired by microorganisms. It shows that the role of multipurpose medicines modified at the molecular scale by optical methods in long-term space missions should be considered in more detail. Solutions to maintain drug stability, even in extreme environmental conditions, are also discussed, such as those that would be encountered during long-duration space exploratory missions. While the microgravity conditions may not be avoided in space, the suggested approaches deal with the radiation-induced modifications in humans, bacteria and medicines onboard, which may be fought by novel pharmaceutical formulation strategies along with radioprotective packaging and storage.

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“…An older review by Klán contains a thorough description of the big spectrum of available PPGs [19] . During the revision of this manuscript, two other reviews on PPGs have been published – one by Weinstain, Klán and coworkers provides a comprehensive review of the PPGs that absorb visible and NIR light, including both organic and metal‐containing groups, [20] and another by Szymanski and coworkers discusses the optimal parameters of PPGs depending on their medical application [21] …”

Section: Introductionmentioning

confidence: 99%

In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies

Josa-Culleré

Llebaría

2020

ChemPhotoChem

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Photopharmacological tools enable the precise spatiotemporal control of small molecule drugs. Amongst them, caged compounds incorporate a photolabile moiety which is released under illumination, thus liberating the active molecule. Caging groups have long been known and many chemical scaffolds have already been used in different applications. However, most of the initial examples are cleaved with UV light, which suffers from low tissue permeability and cell damage. Recently, caging groups that are released under visible light have been reported, which expand their utility. In this review, we outline the chemical strategies that have been used to increase the absorption wavelengths; we compare their photophysical properties, discuss their synthetic accessibility, and exemplify some of their biological applications.

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Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Cited by 426 publications

References 1,802 publications

Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives

Effects of Substituents on Photophysical and CO-Photoreleasing Properties of 2,6-Substituted meso-Carboxy BODIPY Derivatives

Stability of Antimicrobial Drug Molecules in Different Gravitational and Radiation Conditions in View of Applications during Outer Space Missions

In the Search for Photocages Cleavable with Visible Light: An Overview of Recent Advances and Chemical Strategies

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