In the present study, we used device visualization in tandem with deep learning to detect weeds in the wheat crop system in actual time. We selected the PMAS Arid Agriculture University research farm and wheat crop fields in diverse weather environments to collect the weed images. Some 6000 images were collected for the study. Throughout the season, tfhe databank was assembled to detect the weeds. For this study, we used two different frameworks, TensorFlow and PyTorch, to apply deep learning algorithms. PyTorch’s implementation of deep learning algorithms performed comparatively better than that of TensorFlow. We concluded that the neural network implemented through the PyTorch framework achieves a superior outcome in speed and accuracy compared to other networks, such as YOLO variants. This work implemented deep learning models for weed detection using different frameworks. While working on real-time detection models, it is very important to consider the inference time and detection accuracy. Therefore, we have compared the results in terms of execution time and prediction accuracy. In particular, the accuracy of weed removal from wheat crops was judged to be 0.89 and 0.91, respectively, with inference times of 9.43 ms and 12.38 ms on the NVIDIA RTX2070 GPU for each picture (640 × 640).