“…Here we apply this principle to a classic controversy in psychology and psychiatry: namely, the relationship between spiritual experiences and psychosis. It has long been noted that certain spiritual and early and acute psychotic experiences exhibit similar features such as anomalous self-experience, magical thinking and perceptual aberrations ( Baldacchino, 2016 ; Buckley, 1981 ; Cangas et al, 2008 ; Crespi et al, 2019 ; Grof and Grof, 1989 ; Hunt, 2000 , 2007 ; Jackson, 1997 ; Jaynes, 1976 ; Luhrmann, 2017 ; Lukoff, 1985 , 2007 , 2018 ; Murray et al, 2012 ; Parnas and Henriksen, 2016 ; Perry, 1977 ; Polimeni, 2018 ; Powers and Corlett, 2018 ; Ross and McKay, 2018 ; Willard and Norenzayan, 2017 ). All three phenomena are reliably induced by 5-HT2AR agonist psychedelics ( Carhart-Harris, 2007 ; Carhart-Harris and Friston, 2010 ; Kraehenmann et al., 2017 ; Letheby, 2016 ; Millière, 2017 ; Nour et al, 2016 ), thus implying their relationship to a more fundamental state – the 5-HT2ARR-mediated PiMS.…”