Visual analysis of the research trend and status on the association between vitamin D and immunity: From 2012 to 2021

Abstract

ObjectiveWe conducted this study to visualize hot spots and trends in the correlation between vitamin D and immunity over the past decade with bibliometric analysis.MethodsWe collected relevant articles in the Web of Science Core Collection from 2012 to 2021 as the data source, and then used CiteSpace software to perform the data analysis. Some graphics were done with Graphpad software.ResultsA total of 1,656 articles were retrieved, with an average citation count of 25.2 times. The United States (439 articles, 26.51%) has the top number of published articles, followed by China (164 articles, 9.90%), England (135 articles, 8.15%), Italy (114 articles, 6.88%), and India (82 articles, 4.95%). The most literature is found in areas of Immunology (337 articles, 20.35%) and Biochemistry Molecular Biology (179 articles, 10.81%). In terms of institutions, the top five institutions with the highest number of publications all belong to Europe. Among them, the League of European Research Universities (LERU) (121, 7.31%) has a greater proportion of output articles. The United States Department of Health Human Services (225, 13.59%) and National Institutes of Health United States (223, 13.47%) funded most articles. The leading five authors with the largest number of publications were Hewison M (19, 1.15%), Bergman P (14, 0.85%), Agerberth B (13, 0.76%), Carlberg C (12, 0.73%), and White JH (12, 0.73%). The top five keywords with the highest co-occurrence frequency are “vitamin d” (367), “d deficiency” (217), “expression” (195), “association” (151), and “d receptor” (132). Among the 17 keyword clusters, the largest cluster is #0 “diet.” Despite cluster #13 “covid-19,” most of the clusters were conducted the studies before 2012.ConclusionThe overall development of research in this field is promising. Western developed countries made outstanding contributions in this area and still take the leading role. But the participation of developing and low-income countries is also impressive. The potential therapeutic effects of vitamin D in immune-related diseases have been noted, especially in multiple sclerosis, COVID-19, etc. This is also the focus and frontier of current research. However, there is still no consensus conclusion in this field. Further research is needed in the future.

The research on the treatment of primary immunodeficiency diseases by hematopoietic stem cell transplantation: A bibliometric analysis from 2013 to 2022

“…[ 42 , 43 ] The timeline view visually reveals the historical span of the literature and is used to track the progression of research trends. [ 44 ] Therefore, it is reasonable to conclude that “gene therapy” has been a topic of interest in recent years. Advances in gene editing can now offer potentially effective options for treating PIDs, which are mostly monogenic diseases.…”

Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023

“…For experienced and active researchers, systematic reviews aid in keeping abreast of the latest advancements in their field ( Chen and Song, 2019 ). Scholarly analysis using bibliometric methods has explored the role of vitamin D in immunity ( Luo et al, 2022 ), bone metabolism ( Malik et al, 2022 ), infections ( He et al, 2022 ), reproductive health ( Lu et al, 2022 ), and non-alcoholic fatty liver disease ( Wang and Chang, 2023 ). However, the relationship between vitamin D and obesity remains unexplored, which is particularly intriguing given the high prevalence of vitamin D deficiency in obese individuals and its potential implications for metabolic health.…”

Vitamin D-Dependent Mechanisms of Intestinal Barrier Permeability Regulation: New Aspects in the Food Tolerance and Food Allergy Formation. Literature Review

“…В последние десятилетия молекулярно-генетические особенности метаболизма витамина D привлекают внимание многих исследователей [1][2][3][4]. Библиометрический анализ, проведенный X. Luo с соавторами (2022) с 2012 по 2022 год [1], продемонстрировал ежегодное увеличение количества таких публикаций -со 131 в 2012 г. до 266 в 2021 г., при этом исследования охватывали 72 научных направления, среди которых лидировали Иммунология (337 статей, 20,35%) и Молекулярная биология (179 статей, 10,81%). Следует отметить, что в последние годы количество научных публикаций значительно выросло именно в этих областях, что обусловлено описанием иммуномодулирующей активности витамина D [2].…”