In the past two decades, whole slide imaging (WSI) has been increasingly used in clinical pathology, research and education thanks to advances in technology. However, existing digital slide scanners for WSI are incapable of efficiently scanning cytology specimens in "glass-faithful quality". In particular, cervical cytology specimens used for cervical cancer screening need to be imaged at multiple focal planes and at high spatial resolution. So, the aim of this thesis is to develop novel methods for improving the scan efficiency of cytology specimens. Preliminary investigations narrowed the research into two directions: to optimise the scan parameters (e.g. the scan map, the focus profile map and the number of focal planes to be scanned) for scanning cytology specimens, and to investigate the fast slanted (specimen) scan.Creating an accurate scan map followed by estimating the focus profile map of the specimen can significantly reduce the scan time, but previous methods are not robust to slide artefacts such as ink marker and dusts. The first research aspect of this thesis has focused on the development of a robust method that not only creates an accurate scan map but also provides a ranked list of focus candidates required for estimating the focus map. Specifically, tiles representing field-of-views to be scanned at high resolution are located on the low resolution images and evaluated with regards to whether they contain foreground objects and how good they are as focus candidates. Four metrics were proposed for the tile evaluation: threshold index (TI) that measures the image intensity; normalised auto-correlation index (NACI) that measures the spatial image similarity; auto-phase correlation index (APCI) that measures the image phase diversity; and entropy index (EI) that measures the predictability of image intensities. The experimental results indicated that while NACI, APCI and EI are effective for specimen delineation, only APCI is capable of selecting superior focus candidates and ignoring artefacts.Knowing the three-dimensional distribution of the specimen can help to determine the minimal number of focal planes to be acquired, and hence the minimal scan time. A method has been developed to evaluate the thickness of all cell and cell clumps in cervical cytology specimens incorporating an exhaustive high-resolution scan, an over-complete wavelet transform across multi-focal planes and a cell clump segmentation method. The accuracy and usefulness of the method was evaluated and demonstrated by quantitative analysis of ten Pap stained Thin-prep cervical slides. In particular, it was found that creating a focus profile map was able to reduce the number of scanning focal planes from 25.4 to 21.4 on average. It was also shown that the distribution of cells was skewed towards the cover-slip (top of the slide), so by considering the thickness of the specimen, an improved focal map i can be produced to further reduce the required number of 1 micron spaced focal planes to 18.6.The last research aspect of...