Visual dysfunction is associated with cognitive impairment in Parkinson's disease

Pino, Rocío Del; Acera, Marian; Murueta‐Goyena, Ane; Lucas‐Jiménez, Olaia; Ojeda, Natalia; Ibarretxe‐Bilbao, Naroa; Peña, Javier; Reyero, Paula; Cortés, Jesús M.; Tijero, Beatriz; Galdós, Marta Barandiarán; Gómez‐Esteban, Juan Carlos; Gabilondo, Iñigo

doi:10.1016/j.parkreldis.2021.10.005

Cited by 9 publications

(11 citation statements)

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“…It was reported that VI could predict CFI in patients with Parkinson’s disease. 44–46 Gbessemehlan A 47 et al suggested that improving vision might be an easy way to decrease the incidence of cognitive disorders. Several ophthalmology studies reported similar results.…”

Section: Discussionmentioning

confidence: 99%

Visual impairment as a risk factor of cognitive function impairment A six-year cohort study

Cao

Hao

Wang

2023

European Journal of Ophthalmology

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Purpose To explore whether baseline visual impairment (VI) increases the risk of cognitive function impairment (CFI). Methods We conducted a population-based cohort study, with a six-year follow-up period. The exposure factor of interest in this study was VI. The Mini-Mental State Examination (MMSE) was used to assess participants’ cognitive function. The Logistic regression model was used to investigate whether baseline VI had an effect on CFI. Confounding factors were adjusted in the regression model. The odds ratio (OR) and 95% confidence interval (CI) were used to quantify the effect of VI on CFI. Results A total of 3297 participants were included in the present study. The mean age of included participants was 58.5 ± 7.2 years. Male accounted for 1480 (44.9%) of all participants. At baseline, 127 (3.9%) of the participants had VI. The MMSE score of participants who had VI at baseline decreased by 1.7 ± 3.3 points on average during the six-year follow-up, and that of participants who had no VI at baseline decreased by 1.1 ± 3.3 points on average. The difference was significant (t = 2.03, p = 0.040). Results of the multivariable Logistic regression model showed that VI was a risk factor for CFI, with an OR of 1.052 (95%CI: 1.014 to 1.092, p = 0.017). Conclusions Averagely, participants with VI experienced a decline in cognitive function 0.1 points faster per year than participants without VI, as measured by MMSE score. VI is an independent risk factor for CFI.

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Section: Discussionmentioning

confidence: 99%

Visual impairment as a risk factor of cognitive function impairment A six-year cohort study

Cao

Hao

Wang

2023

European Journal of Ophthalmology

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“…Given that the DMN and FPN mainly function in high-order cognitive processing (41,42), the diverse alterations in these networks in cognitively normal patients might be interactive activities for the preservation of cognition. Similarly, the increased nodal strengths in the VN and SN could be interpreted as the neural plasticity that responds to motor dysfunction, which would be impaired dominantly in conditions of cognitive impairment (24,43).…”

Section: Discussionmentioning

confidence: 99%

Application of diffusional kurtosis imaging for insights into structurally aberrant topology in Parkinson's disease

Zhu,

Wang,

et al. 2023

Acta Radiol

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Background Parkinson's disease (PD) has been regarded as a disconnection syndrome with functional and structural disturbances. However, as the anatomic determinants, the structural disconnections in PD have yet to be fully elucidated. Purpose To non-invasively construct structural networks based on microstructural complexity and to further investigate their potential topological abnormalities in PD given the technical superiority of diffusion kurtosis imaging (DKI) to the quantification of microstructure. Material and Methods The microstructural data of gray matter in both the PD group and the healthy control (HC) group were acquired using DKI. The structural networks were constructed at the group level by a covariation approach, followed by the calculation of topological properties based on graph theory and statistical comparisons between groups. Results A total of 51 patients with PD and 50 HCs were enrolled. Individuals were matched between groups with respect to demographic characteristics ( P >0.05). The constructed structural networks in both the PD and HC groups featured small-world properties. In comparison with the HC group, the PD group exhibited significantly altered global properties, with higher normalized characteristic path lengths, clustering coefficients, local efficiency values, and characteristic path lengths and lower global efﬁciency values ( P <0.05). In terms of nodal centralities, extensive nodal disruptions were observed in patients with PD ( P <0.05); these disruptions were mainly distributed in the sensorimotor network, default mode network, frontal-parietal network, visual network, and subcortical network. Conclusion These findings contribute to the technical application of DKI and the elucidation of disconnection syndrome in PD.

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“…Visual cognition deficits have been commonly reported in PD, although there is no consensus regarding frequency, characteristics, and relationships with other variables. Nevertheless, although many authors agree that visual cognition is not the most affected domain in PD [ 92 , 93 ], the majority of studies report a significant decline in visuospatial, visuoperceptive, visuoconstructive, and visual memory functions [ 94 , 95 , 96 ].…”

Section: Visual Cognition Impairments In Parkinson’s Diseasementioning

confidence: 99%

“…But, visual scenery generation and perception are simultaneously coupled with cognitive processes [ 99 ]. Thus, it has been reported that PD patients’ performance in a wide range of neuropsychological tests involving visual cognition can be attributed to abnormalities in low-level visual functions, especially low- and high-contrast visual acuity [ 96 ]. And, it has been suggested that lower-level vision acts as a confounder in object identification or in the time needed to interpret visual sceneries [ 96 ].…”

Section: Visual Cognition Impairments In Parkinson’s Diseasementioning

confidence: 99%

Visual Dysfunction in Parkinson’s Disease

2023

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Non-motor symptoms in Parkinson’s disease (PD) include ocular, visuoperceptive, and visuospatial impairments, which can occur as a result of the underlying neurodegenerative process. Ocular impairments can affect various aspects of vision and eye movement. Thus, patients can show dry eyes, blepharospasm, reduced blink rate, saccadic eye movement abnormalities, smooth pursuit deficits, and impaired voluntary and reflexive eye movements. Furthermore, visuoperceptive impairments affect the ability to perceive and recognize visual stimuli accurately, including impaired contrast sensitivity and reduced visual acuity, color discrimination, and object recognition. Visuospatial impairments are also remarkable, including difficulties perceiving and interpreting spatial relationships between objects and difficulties judging distances or navigating through the environment. Moreover, PD patients can present visuospatial attention problems, with difficulties attending to visual stimuli in a spatially organized manner. Moreover, PD patients also show perceptual disturbances affecting their ability to interpret and determine meaning from visual stimuli. And, for instance, visual hallucinations are common in PD patients. Nevertheless, the neurobiological bases of visual-related disorders in PD are complex and not fully understood. This review intends to provide a comprehensive description of visual disturbances in PD, from sensory to perceptual alterations, addressing their neuroanatomical, functional, and neurochemical correlates. Structural changes, particularly in posterior cortical regions, are described, as well as functional alterations, both in cortical and subcortical regions, which are shown in relation to specific neuropsychological results. Similarly, although the involvement of different neurotransmitter systems is controversial, data about neurochemical alterations related to visual impairments are presented, especially dopaminergic, cholinergic, and serotoninergic systems.

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Visual dysfunction is associated with cognitive impairment in Parkinson's disease

Cited by 9 publications

References 10 publications

Visual impairment as a risk factor of cognitive function impairment A six-year cohort study

Visual impairment as a risk factor of cognitive function impairment A six-year cohort study

Application of diffusional kurtosis imaging for insights into structurally aberrant topology in Parkinson's disease

Visual Dysfunction in Parkinson’s Disease

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