Visual evoked potential changes in patients with diabetes mellitus without retinopathy

Gupta, S. K.; Gupta, Gaurav; Deshpande, Vrushak

doi:10.18203/2320-6012.ijrms20151405

Cited by 14 publications

(12 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, both 60 min and 15 min test results of group A revealed a statistically significant delay in the P100 latency and a decrease in the P100 amplitude when compared with the controls results, and these results were in accordance with those of Gupta et al [ 16 ] for the 60 min test and with those of Heravian et al [ 17 ] for the 15 min test. In addition, the presence of early NPDR clinical findings in group B was associated with a more deranged PRVEP test parameters; these results were in accordance with other studies' results [ 17 , 18 ].…”

Section: Discussionsupporting

confidence: 92%

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Al-Najjar

Al-Aubody

Al-Asadi

et al. 2020

Neurology Research International

View full text Add to dashboard Cite

Background. Currently, diabetic retinopathy (DR) has a wide recognition as a neurovascular rather than a microvascular diabetic complication with an increasing need for enhanced detection approaches. Pattern-reversal visual evoked potentials (PRVEPs) test, as an objective electrophysiological measure of the optic nerve and retinal function, can be of great value in the detection of diabetic retinal changes. Objectives. The use of two sizes of checkerboard PRVEPs testing to detect any neurological changes in persons with type 2 diabetes mellitus (T2DM) with and without a clinically detected DR. Also, to compare the results according to the candidate age, duration, and glycemic status of T2DM. Methods. This study included 50 candidates as group A with T2DM and did not have a clinically detected DR and 50 candidates as group B with T2DM and had a clinically detected early DR and 50 candidates as controls who were neither diabetic nor had any other medical or ophthalmic condition that might affect PRVEPs test results. The PRVEPs were recorded in the consultant unit of ophthalmology in Almawani Teaching Hospital. Monocular PRVEPs testing of both eyes was done by using large (60 min) and small (15 min) checks to measure N75 latency and P100 latency and amplitude. Results. There was a statistically significant P100 latency delay and P100 amplitude reduction in both groups A and B in comparison with the controls. The difference between groups A and B was also significant. In both test results of groups A and B, the proportions of abnormal P100 latency were higher than those of P100 amplitude with a higher abnormal proportions in 15 min test. Conclusions. The PRVEP test detected neurological changes, mainly as conductive alterations affecting mostly the foveal region prior to any overt DR clinical changes, and these alterations were heightened by the presence of DR clinical changes.

show abstract

Section: Discussionsupporting

confidence: 92%

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Al-Najjar

Al-Aubody

Al-Asadi

et al. 2020

Neurology Research International

View full text Add to dashboard Cite

show abstract

“…The visual evoked potential (VEP), which assesses the integrity of the neural pathways of vision is a very sensitive indicator of electrophysiological changes of visual pathway and even a minor alteration in P100 latency reflects changes in neurophysiological sensitivity in diabetes [15,18]. In present study, prolonged latency and decreased amplitude of P100 wave in VEP (Table 3) was observed in diabetics when compared with controls which is similar to other studies [15,19]. This delayed latency indicates that there may be pathologic demyelinating lesions of the optic tract although in the present study none had history of optic neuropathy or functional anomalies in peripheral neuropathy [18,20].…”

Section: Discussionsupporting

confidence: 90%

Delayed Visual Evoked Response is Linked to Vascular Endothelial Growth Factor and Autonomic Dysfunction in Type 2 Diabetes Mellitus

Sirisha¹,

Yerrabelli²,

Pal³

et al. 2019

J Diabetes Metab

View full text Add to dashboard Cite

Aims: In this study, we aimed to assess the link between visual evoked potentials (VEP), angiogenic marker (VEGF) and autonomic function tests in type-2 diabetes mellitus (T2DM). Methods: Age-matched 86 male subjects (44 type-2 diabetics on treatment and 42 normal healthy volunteers) were recruited for this study. Body mass index (BMI), basal cardiovascular parameters, spectral analysis of heart rate variability (HRV), were assessed. Fasting blood glucose, insulin, HOMA-IR and VEGF were estimated. The independent association of the P100 latency of VEP with VEGF was determined by multiple regression analysis. Results: LF-HF ratio a marker of sympathovagal balance, increased significantly (p=0.0287) in diabetic group compared to the control group. Comparison of visual evoked potentials between controls and diabetic groups showed significant increase in latency of P100 of both the eyes (right eye p<0.0001, left eye p=0.0003) among the cases. There was significant increase (p=0.0091) in VEGF in diabetic subjects when compared to control. Also positive and significant correlation of P100 latency of VEP with VEGF is seen in diabetics. Conclusions: There is delayed latency of VEP and increased VEGF in type 2 diabetic people. The correlation between VEP and VEGF could indicate the probable role of angiogenesis leading to reduced integrity of the neural pathways in T2DM.

show abstract

“…6,19 Pada penelitian ini, subjek DMT2 tanpa retinopati juga memiliki pemanjangan latensi P100 mata kanan (70%) dan mata kiri (70,97%), sama dengan Gupta dkk yang mendapatkan abnormalitas VEP pada 80% pasien DMT2 tanpa retinopati. [14][15][16][17][18][19] Pemanjangan latensi ini dapat merupakan tanda adanya proses neurodegenerasi atau kerusakan pada lapisan sel ganglion retina yang terjadi sebelum munculnya retinopati yang terdeteksi dengan funduskopi. [20][21] Berdasarkan hasil analisis bivariat didapatkan hubungan bermakna dengan korelasi positif kuat antara lamanya DMT2 dan latensi P100.…”

Section: Variabelunclassified

“…Iskemia, penurunan sintesis protein, deplesi myoinositol, peningkatan kadar sorbitol, dan akumulasi sitokin neuropoietik turut berkontribusi terhadap kehilangan serabut saraf optikus. [13][14] Gangguan sistem visual yang terjadi pada DMT2 dapat menurunkan kualitas hidup pasien. Kerusakan pada lapisan neurosensorik retina dan serabut saraf optikus dapat terjadi pada tahap yang lebih awal sebelum terjadinya perubahan struktural yang dapat terlihat pada funduskopi.…”

unclassified

Peran Visual Evoked Potential Pada Pasien Diabetes Melitus Tipe-2 Dengan Dan Tanpa Retinopati Diabetik

Tanawal

Tumboimbela

Mahama

2018

View full text Add to dashboard Cite

ROLE OF VISUAL EVOKED POTENTIAL IN TYPE-2 DIABETES MELLITUS WITH AND WITHOUT DIABETIC RETINOPATHYABSTRACTIntroduction: Diabetic retinopathy (DR) is a common complication of type-2 diabetes mellitus (T2DM). Minimal functional change of neural layers of the retina occurs before structural changes, thus undetected by funduscopy. This damage could be identified earlier by P100 latency changes in visual evoked potential (VEP).Aims: To find the characteristic of P100 in T2DM with and without DR, its correlation with the duration of thedisease and the level of fasting blood glucose (FBG).Methods: A cross sectional analysis study was conducted in Prof. dr. R.D. Kandou Hospital, Manado, from November2017-January 2018. T2DM patients aged 18-60 with visual acuity >6/60, without neuro-ophtalmological disorders and other metabolic diseases. P100 latency was measured using VEP with reversed checkerboard stimulation.Results: There were 56 subjects with T2DM, mostly were females (57,1%) and age mean was 54,86±5,65 years. Delayed P100 latency occurred in 85,7% subjects. Diabetic retinopathy subjects showed delayed P100 latency on right (92,31%) and left (88%) eyes while T2DM subjects without retinopathy showed delayed P100 latency on both eyes 70%. There were strong and significant positive correlation between the duration of T2DM and P100 latency on the right and left eyes. There was no significant correlation between fasting blood glucose (FBG) level and P100 latency.Discussions: Delayed P100 latency occurs in T2DM patients with and without retinopathy. The duration of T2DMcorrelates with the delay of P100 latency but not with the level of FBG.Keywords: Diabetic retinopathy, P100, type-2 diabetes mellitus, visual evoked potential ABSTRAKPendahuluan: Retinopati diabetik adalah suatu komplikasi yang umum terjadi pada diabetes melitus tipe-2 (DMT2). Sebelum terjadinya perubahan struktural, lapisan neuron retina pasien DMT2 sudah mengalami perubahan fungsional minimal yang tidak terdeteksi dengan funduskopi. Hal ini dapat diidentifikasi lebih dini berdasarkan gambaran latensi gelombang P100 pada pemeriksaan visual evoked potential (VEP).Tujuan: Untuk mengetahui karakteristik nilai gelombang P100 pada pasien DMT2 dengan dan tanpa retinopati diabetik, serta hubungannya dengan lama penyakit dan kadar glukosa darah puasa (GDP).Metode: Penelitian analitik dengan desain potong lintang terhadap pasien DMT2 yang dirawat di RSUP Prof. dr. R.D. Kandou, Manado periode November 2017-Januari 2018. Subjek berusia 18-60 tahun dengan visus >6/60 tanpa adanya kelainan neuro-oftamologi dan penyakit metabolik lain. Dilakukan perekaman VEP menggunakan stimulasi reversed checkerboard dilanjutkan pengukuran latensi gelombang P100.Hasil: Didapatkan 56 subjek, paling banyak perempuan (57,1%) dan rerata usia 54,86±5,65 tahun. Latensi P100 memanjang pada 85,7% subjek. Pada subjek dengan retinopati ditemukan mayoritas mengalami pemanjangan latensi pada mata kanan (92,31%) dan mata kiri (88%), sedangkan pada subjek tanpa retinopati ditemukan pemanjangan latensi kedua mata adalah 70%. Terdapat hubungan bermakna dengan korelasi positif kuat antara lamanya DMT2 dan latensi P100 kanan dan kiri. Tidak terdapat hubungan yang bermakna antara kadar GDP dan latensi P100.Diskusi: Pemanjangan latensi P100 terjadi pada subjek DMT2 dengan dan tanpa retinopati. Lamanya DMT2 berhubungan dengan pemanjangan latensi P100, tetapi kadar GDP tidak berhubungan dengan pemanjangan latensi P100.Kata kunci: Diabetes melitus tipe-2, P100, retinopati diabetik, visual evoked potential

show abstract

Visual evoked potential changes in patients with diabetes mellitus without retinopathy

Cited by 14 publications

References 22 publications

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Pattern-Reversal Visual Evoked Potentials Tests in Persons with Type 2 Diabetes Mellitus with and without Diabetic Retinopathy

Delayed Visual Evoked Response is Linked to Vascular Endothelial Growth Factor and Autonomic Dysfunction in Type 2 Diabetes Mellitus

Peran Visual Evoked Potential Pada Pasien Diabetes Melitus Tipe-2 Dengan Dan Tanpa Retinopati Diabetik

Contact Info

Product

Resources

About