Visual evoked potentials and MBP gene expression imply endogenous myelin repair in adult rat optic nerve and chiasm following local lysolecithin induced demyelination

Skin-derived neural precursors competitively generate functional myelin in adult demyelinated mice

“…Difference in conduction velocity or latency responses in intact versus demyelinated shiverer mice treated with medium were not detected. This was predictable, since spontaneous remyelination restores the demyelination-induced altered electrophysiological function (36)(37)(38). However, engraftment of miPS-derived cells decreased the latency response and consequently increased axonal conduction velocity of the adult shiverer axon, as previously observed in vitro (39) and in vivo (19) for primary glial or neural progenitors.…”

Predictors of response to opicinumab in acute optic neuritis

“…VEP latency is a sensitive indicator of demyelination and subsequent remyelination in models of optic neuritis 15, 16. RENEW used the latency of the unaffected eye at baseline to measure the extent of recovery in the affected eye across 32 weeks.…”

Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial

“…VEP latency is a sensitive measure of demyelination and subsequent remyelination in optic neuritis models. [13][14][15] In participants presenting with an episode of acute optic neuritis, such as those enrolled in RENEW, baseline aff ected eye latency from demyelination cannot be assessed because of oedema and the frequent prevalence of conduction block. To overcome this limitation in the design of the RENEW study, we calculated the diff erence in aff ected eye VEP latency over time using the unaff ected fellow eye baseline value as the pretreatment normal reference value.…”