Visual field analysis in patients with Parkinson's disease

Yenice, Özlem; Onal, Sumru; Midi, İpek; Özcan, Eda; Temel, Ayla Bayık; I-Gunal, Dilek

doi:10.1016/j.parkreldis.2007.07.018

Cited by 45 publications

(36 citation statements)

References 22 publications

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“…Interestingly, in these studies PD patients had normal or significantly lower IOP values compared to controls. This data was also confirmed by Yenice et al (2008) and Tsironi et al (2012), which reported a higher prevalence of glaucomatous visual field defects in patients with PD. These alterations have been subsequently corroborated by several studies reporting a significantly reduced RNFL thickness in patients with PD (Inzelberg et al, 2004;Altinta,ş et al, 2008;Eraslan et al, 2015).…”

Section: Glaucoma and Neurodegenerative Diseasessupporting

confidence: 75%

New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system

Nucci

Russo

Martucci

et al. 2016

European Journal of Pharmacology

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a b s t r a c tGlaucoma is a disease where retinal ganglion cells (RGC) are specifically affected though a number of evidences endorse the hypothesis that glaucoma is a neuro-degenerative disorder of the central nervous system and suggest a possible connection between glaucomatous damage and cerebrovascular alterations. The mechanisms underlying RGC loss are not yet fully known but alterations of the autophagy machinery have been recently proposed as a potential contributing factor as for Alzheimer's disease.Here we review the current literature on new strategies for neuroprotection in glaucoma, focusing on pharmacologic strategies to minimize RGC damage.

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Section: Glaucoma and Neurodegenerative Diseasessupporting

confidence: 75%

New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system

Nucci

Russo

Martucci

et al. 2016

European Journal of Pharmacology

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“…For example, it is used to detect and monitor the progression of visual-field loss in a range of ocular and/or neurological diseases, such as glaucoma, macular degeneration, retinitis pigmentosa (RP), acquired brain injury (ABI), Parkinson's disease, and Alzheimer's disease [1,2]. However, in many cases, assessment of the visual field is considered to be unreliable with poor repeatability [3,4].…”

Section: Introductionmentioning

confidence: 99%

Effect of different stimulus configurations on the visual evoked potential (VEP)

2012

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The purpose of this study was to assess changes in the response profile of the pattern visual evoked potential (VEP) using three stimulus configurations simulating visual-field scotomas: central circular and central blank fields increasing incrementally in diameter from 1° to 15°, hemi-field, and quadrant patterns. Five visually normal adult subjects (ages 22-68 years) were tested binocularly at 1 m for each stimulus configuration on 5 separate days. A checkerboard test pattern (64 × 64 black-and-white checks, 85% contrast, 64 cd/m(2) luminance, 20 s of stimulus duration, 2-Hz temporal frequency) was used. The group mean VEP amplitude increased in a linear manner with increase in the central circular diameter (y = 0.805x + 2.00; r = 0.986) and decrease in central blank field diameter (y = -0.769x + 16.22; r = 0.987). There was no significant change in latency in nearly all cases. The group mean coefficient of variability results indicated that the VEP amplitude was repeatable for the different stimulus configurations. The finding of VEP response linearity for the circular stimulus fields, and repeatability for all stimulus configurations, suggests that the clinician may be able to use the VEP technique with the suggested test patterns as a rapid and simple tool for objective assessment for several types of visual-field defects for a range of abnormal visual conditions and special populations.

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“…Literary sources describe not uncommon visual-field defect in patients with PD, similar to those found in glaucoma, moreover, these examination covered only subjects with eliminated ophthalmological disorders, without glaucoma in their family histories; a post hoc analysis proved absence of glaucoma during subsequent time [29]. Threshold perimetry revealed most frequently changes in visual field in the lower and temporal areas, which were often topographically concordant with the thin areas in the retina found by optical coherent tomography.…”

Section: IIImentioning

confidence: 81%

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Oa¹,

Sa²,

Oi³

2017

JNSK

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Among non-motor symptoms in patients with Parkinson's disease (PD) have a number of specific visual disturbances. This review describes the main visual problems associated with PD, referring to their basic anatomical aspects and pathophysiological mechanisms. A wide range of visual disorders includes changes in color vision and contrast sensitivity, change in the electrophysiological properties of the retina due to the insufficiency of the retinal dopaminergic system, features of visual field defects, visuospatial and visuoperceptual impairments. The use of modern electrophysiological, neurophysiological, psychophysiological and other research methods makes it possible to comprehensively assess the state of all parts of the visual analyzer from the retina to the higher cortical centers in patients with PD. The article discusses controversial questions about the relationship between changes in color vision, a decrease in the level of contrast sensitivity and severity of motor disorders in Parkinson's disease. Finally, we discuss the advantages of using threshold and blue-yellow perimetry as more sensitive methods in detecting visual field defects in patients with PD. Keywords:

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Visual field analysis in patients with Parkinson's disease

Cited by 45 publications

References 22 publications

New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system

New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system

Effect of different stimulus configurations on the visual evoked potential (VEP)

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

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