Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Rulli, Eliana; Quaranta, Luciano; Riva, Ivano; Poli, Davide; Hollander, Lital; Galli, Fábio; Katsanos, Andreas; Oddone, Francesco; Torri, Valter; Weinreb, Robert N.; Varano, L; Carchedi, T.; Talarico, Sérgio; Parravano, F.; Motolese, Ilaria; Bagaglia, Simone Alex; Rossi, Gemma Caterina Maria; Lateri, S.; Bossolesi, Laura; Carmassi, L.; Rolle, Teresa; Piccini, R.; Ratiglia, Roberto; Rossi, Alessandro; Gandolfi, Stefano; Tagliavini, Viola; Ungaro, Nicola; Fossarello, Maurizio; Cucca, Alberto; Zucca, Ignazio Alberto; Uva, Michele; Bonacci, Erika; Cardarella, G.; Tognetto, Daniele; Vattovani, Odilla; Vallon, P.; Iannacone, F.; Fontana, Luigi; Marchi, S.; Manni, Gianluca; Jannetta, D.; Roberti, Giulio Mirabella; Rossetti, L.; Maggiolo, Emanuele; Oneta, O.; Sborgia, Carlo; Cantatore, Francesco Paolo; Mastropasqua, Leonardo; Agnifili, Luca; Campos, Emilio C.; Gizzi, Corrado; Giannaccare, Giuseppe; Pucci, Vincenzo; Cassamali, M.; Costagliola, Ciro; Traverso, C. E.; Scotto, Riccardo; Musolino, Maria; Landi, Laura; Bagnis, Alessandro

doi:10.1038/s41598-017-19113-z

Cited by 46 publications

(40 citation statements)

References 80 publications

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“…[ 25 , 26 ] It was reported that the QOL in glaucoma was significantly correlated with visual impairment of physical function, social activities and psychosocial factors, [ 27 – 30 ] among which binocular visual function has the most intimate relationship. [ 31 , 32 ] In addition, once glaucoma is diagnosed, many patients’ QOL decreases significantly, mainly due to inconvenient treatment and afraid of blindness. [ 33 ] During clinical practice, patients with the same stage of VF defect showing various QOL, or same QOL demonstrate diverse severity of VF defect, which might not be explained by visual function assessment based on monocular VF loss.…”

Section: Discussionmentioning

confidence: 99%

Impact of binocular integrated visual field defects on healthy related quality of life in glaucoma

Zhao

Cun

et al. 2021

Medicine

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To investigate the impact of different types of binocular integrated visual field defects on the quality of life in glaucoma. Ninety-six patients with primary glaucoma were divided into 5 groups with 25, 24, 11, 15, and 21 patients according to types of the binocular integrated visual field (BVF) defects. The criteria for BVF grouping included mild visual field defect in binocular eyes, mild visual field defect in 1 eye and moderate or advanced defect in the other, moderate and non-overlapping visual field defect in both eyes, overlapping and moderate visual field defect in binocular eyes, and severe defect in both eyes, respectively. The visual field (VF) evaluation was based on H-P-A visual field grading system. Visual acuity, visual field tests and Glaucoma Quality of Life-15 Questionnaire (GQL-15) were performed for enrolled patients, and binocular visual field results were integrated. The changes and correlations of the Visual field index values and quality of life scores were compared among the 5 groups. The main factors affecting the quality of life in glaucoma were analyzed by multiple regression analysis. The best binocular integrated visual field index (BVFI) and optimal quality of life were observed in group A. The BVFI of group B was better than that of group C or group D, but the peripheral vision glare and dark adaptation were worse. No significant difference was noted between group C and group D in terms of BVFI. However, the glare and dark adaptation in group C were better than that in group D. The BVFI was the lowest and the quality of life was the worst in group E. In all, BVFI and decibels (dB) values were negatively correlated with GQL-15 scores and positively correlated with patients’ quality of life. Binocular integrated visual field accurately reflects the visual function in glaucoma. Higher binocular integrated visual field indices represent a better quality of life for patients with glaucoma. Mild to moderate synchronous or complementary binocular VF defects had a slight effect on the quality of life, while severe and non-compensated VF loss significantly impacts on quality of life in glaucoma patients.

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Section: Discussionmentioning

confidence: 99%

Impact of binocular integrated visual field defects on healthy related quality of life in glaucoma

Zhao

Cun

et al. 2021

Medicine

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“…The Secondary childhood glaucoma is classified into four categories: glaucoma associated with nonacquired ocular anomalies, glaucoma associated with nonacquired systemic anomalies, glaucoma associated with the acquired condition, and glaucoma following cataract surgery [29]. In children, the most common form is PCG, with a prevalence rate of 1:10,000 to 18,000 live births worldwide [30,31]. The frequency of CYP1B1 mutations in people with PCG depends on the population being considered.…”

Section: Cyp1b1 In Glaucomamentioning

confidence: 99%

CYP1B1 gene: Implications in glaucoma and cancer

Alsubait¹,

Aldossary²,

Rashid³

et al. 2020

J. Cancer

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Glaucoma is a serious disease that can lead to irreversible loss of vision. Patients with primary congenital glaucoma may have elevated intraocular pressure. Hypertension causes damages to intraocular structures and affects the Schlemm's canal, collector channels, trabecular meshwork, and optic nerve's molecular structures. An important gene that is defective in patients with glaucoma is CYP1B1, a gene associated with optic nerve deterioration. CYP1B1is a key enzyme involved in the metabolism of exogenous and endogenous compounds. Also, it is critical in the detoxification of pre-carcinogens, such as polycyclic aromatic hydrocarbons and estrogen. It catalyzes their conversion into metabolites subsequently eliminated from the body. In malignant tumors, the CYP1B1 promoter is hypomethylated. CYP1B1 overexpression results in the conversion of estrogens to quinone forms, which bind with DNA and create a predisposition for cancer in several organs, such as the brain, breast, and ovary. Increased cytokine interleukin-6 and leptin lead to elevated CYP1B1 activity, which possibly causes cancer. In addition, the expression of aromatic hydrocarbon receptors is increased in tumor tissues, and it elevates oxidative stress and cell growth. TCGA database analysis showed increased survival at bladder and renal carcinoma when CYP1B1 expression is low. Therefore, alteration of CYP1B1 expression may suggest a therapeutic benefit for multiple diseases such as glaucoma and cancer.

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“…Briefly, previously or newly diagnosed POAG patients aged 18 or more were consecutively enrolled during routine visits at 21 academic and non-academic centers in Italy. In the cross-sectional part of the study, vision-related QoL data were collected and their association with both clinical and socio-demographic variables was investigated 29,30 . In the prospective part of the study, consecutive newly-diagnosed glaucoma patients were evaluated at baseline and were followed-up for one year.…”

Section: Methodsmentioning

confidence: 99%

Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

Riva

Legramandi

Rulli

et al. 2019

Sci Rep

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To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.

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Visual field loss and vision-related quality of life in the Italian Primary Open Angle Glaucoma Study

Cited by 46 publications

References 80 publications

Impact of binocular integrated visual field defects on healthy related quality of life in glaucoma

Impact of binocular integrated visual field defects on healthy related quality of life in glaucoma

CYP1B1 gene: Implications in glaucoma and cancer

Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients

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