Visual Field Tests for Glaucoma Patients With Initial Macular Damage: Comparison Between Frequency-doubling Technology and Standard Automated Perimetry Using 24-2 or 10-2 Visual Fields

Lee, Jiyoung; Park, Chan Kee

doi:10.1097/ijg.0000000000000977

Cited by 7 publications

(4 citation statements)

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“…Second, SAP results are not only affected by the opacity of refractive media but easily disturbed by subjective consciousness. Third, studies [ 17 ] have reported that SAP is prone to miss damage in the central 10° region, leading to an incomplete result. Last but not least, increased thyroid hormones stimulate sympathetic nervous excitement, with clinical manifestations of palpitation, insomnia, emotional agitation, or even anxiety, accompanied by tremoring [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Comparing isolated-check visual evoked potential, pattern visual evoked potential, and standard automated perimetry in dysthyroid optic neuropathy eyes

Tong

et al. 2020

Eye

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Objective To determine the diagnostic ability of isolated-check visual evoked potential (icVEP), pattern visual evoked potential (pVEP), and standard automated perimetry (SAP) between dysthyroid optic neuropathy (DON) and thyroid-associated ophthalmopathy (TAO) without DON (non-DON). Methods This is a case-control study, 49 bilateral patients (26 DON and 23 non-DON) were included. icVEP, pVEP, and SAP were conducted in all the subjects, icVEP parameters compared were signal-to-noise ratios (SNRs) under 8, 16, and 32% depth of modulation (DOM). pVEP parameters compared were amplitude and latency. SAP parameters were mean deviation (MD) and pattern standard deviation (PSD). The area under the receiver operating characteristic (ROC) curve (AUC), net reclassification index (NRI), integrated discrimination index (IDI), and decision curve analysis (DCA) were applied for analysis. Results In icVEP, values of SNR in DON were significantly smaller than non-DON (p < 0.05). In pVEP, P100 latent time in DON was significantly larger than non-DON (p = 0.0026). In SAP, value of PSD in DON was larger than non-DON (p = 0.0006), and value of MD in DON was smaller (p = 0.0007). AUC, NRI, and IDI among the three tests were not significantly different. DCA showed that SNR of icVEP under 8% DOM was the farthest from the two extreme curves. Conclusions icVEP, pVEP, and SAP have equal diagnostic capabilities to discern between DON and non-DON. In addition, icVEP may represent a significant ancillary diagnostic approach to DON detection, with more clinical benefit.

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Section: Discussionmentioning

confidence: 99%

Comparing isolated-check visual evoked potential, pattern visual evoked potential, and standard automated perimetry in dysthyroid optic neuropathy eyes

Tong

et al. 2020

Eye

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“…Methodologies used in this study were conducted by referring our previous study 38 . In this prospective, observational study, glaucoma patients with initial paracentral scotoma underwent SAP 24-2 and SAP 10-2 VF tests (Carl Zeiss Meditec, Dublin, CA) at the glaucoma clinic of Seoul St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea, between November 2017 and August 2020.…”

Section: Methodsmentioning

confidence: 99%

“…As an initial evaluation, all patients performed a comprehensive ophthalmologic examination, slit-lamp biomicroscopy, Goldmann applanation tonometry, central corneal thickness measurement using ultrasound pachymetry (Tomey Corporation, Nagoya, Japan), gonioscopic examinations, axial length measurement using IOL Master (Carl Zeiss Meditec, Jena, Germany), stereoscopic optic disc photography, dilated stereoscopic examination of the ONH (optic nerve head), red-free photography (VX-10; Kowa Optimed, Tokyo, Japan), Cirrus SD-OCT scans (Carl Zeiss Meditec), and measurement of best-corrected visual acuity 38 .…”

Section: Methodsmentioning

confidence: 99%

Investigation of progression pattern and associated risk factors in glaucoma patients with initial paracentral scotomas using Humphrey 10-2

Kim

Hong

Shin

2021

Sci Rep

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Central visual field (VF) progression could directly threaten patientss visual function compared to glaucomatous damage. This study was designed to investigate visual field (VF) progression pattern and associated risk factors including optical coherence topography angiographic (OCT-A) findings in glaucoma patients with initial paracentral scotoma. This prospective, observational study included 122 eyes presenting as initial paracentral scotomas with serial 24-2 and 10-2 VF tests at the glaucoma clinic of Seoul St Mary's Hospital between November 2017 and August 2020. The participants underwent at least 5 serial VF exams and OCT-A at baseline. Numerical values of the initial and final 10-2 VF tests were averaged for each VF test point using the total deviation map. Innermost 10-2 VF progression was defined as three or more new contiguous points at the central 12 points on 10-2 VF. Other clinical characteristics were collected including history of disc hemorrhage and vessel density (VD) was measured from OCT-A images. Linear regression analysis was performed to obtain the change of mean deviation and a cut-off for progression was defined for both 24-2 and 10-2 VFs. The average total deviation maps of the initial 10-2 VF tests shows initial paracentral scotoma located in the superior region in an arcuate pattern that was deep in the 4°–6° region above fixation. This arcuate pattern was more broadly located in the 4°–10° region in the primary open-angle glaucoma (POAG) group, while it was closer to fixation in 0°–4° region in the normal-tension glaucoma (NTG) group. The final average map shows deepening of scotomas in the 4°–10° region in POAG, which deepened closer to the region of fixation in NTG. The diagnosis of NTG (β 1.892; 95% CI 1.225–2.516; P = 0.035) and lower choroidal VD in the peripapillary atrophy (PPA) region (β 0.985; 95% CI 0.975 to 0.995; P = 0.022) were significantly related to innermost 10-2 VF progression. Initial paracentral scotomas in NTG tended to progress closer to the region of fixation, which should be monitored closely. Important progression risk factors related to paracentral scotoma near the fixation were the diagnosis of NTG and reduced choroidal VD in the β-zone PPA region using OCT-A. We should consider vascular risk factors in NTG patients presenting with initial paracentral scotoma to avoid vision threatening progression of glaucoma.

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“…В настоящее время ряд зарубежных исследователей [12][13][14][15][16][17][18][19][20][21][22] рекомендуют применять HM FDT для скрининга глаукомы, аргументируя более высокой чувствительностью его результатов, несмотря на удлинение времени тестирования каждого глаза примерно в 4 раза (в среднем с 63,1 ± 1,7 до 257,5 ± 9,4 с). Как известно, существуют требования к скринингу, такие как простота и быстрота (не более 5 минут для исследования обоих глаз) при выполнении, достаточная информативность и экономическая доступность метода исследования, претендующего на скрининг [8,23].…”

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Assessment of the Effectiveness of Different Variants of Frequency Doubling Technology Perimetry in Monitoring the Glaucoma Process

2022

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Purpose: To compare the diagnostic effectiveness of non-standard perimetry and standard automated perimetry (SAP) during earlystage monitoring of primary open-angle glaucoma (POAG).Patients and methods. The study involved 30 patients (46 eyes) with early-stage of POAG, aged 30 to 65 years (54.9 ± 1.3), who were under ongoing monitoring for 3 to 4 years (3.50 ± 0.68 years). All subjects, in addition to the standard ophthalmological examination, performed the threshold program “24-2” perimetry using the Humphrey II, the own modification of Frequency Doubling Technology (FDT) Perimetry, in the form of 2 threshold strategies: the wellknown “FDT-16” and the new “FDT-64”. The condition of the optic nerve head (ONH) was assessed using HRT 3 (Heidelberg Retina Tomograph, Germany) and OCT — Topcon 3D OCT- 2000 (TOPCON, Japan). During monitoring, RTVue FD-OCT (Optovue, USA) was additionally performed, evaluating the parameters of the retinal ganglion cell complex (GCC).Results. Regular follow-up, the implementation of the prescribed treatment contributed to the stabilization of glaucoma, as evidenced by the stability of the average MD index values according to all 3 threshold strategies, but reliably (p = 0.000) only according to SAP data. According to the criterion of the number of scotomas, there was a weakly expressed, but statistically significant negative dynamics for all the compared strategies. According to the results of the structural assessment of the ONH (the size of the excavation), a weakly pronounced negative dynamics was obtained in dynamics according to both HRT and OCT data. The average MD index values, the number of scotomas according to the three perimeter strategies and the excavation size based on HRT and OCT in patients with early-stage of POAG turned out to be stronger and more significant using the “FDT-16”, and the correlation characteristics with the results of “24-2” HFA II, “FDT-64” largely coincided.Conclusion. A reliable correlation between structural and functional parameters indicates the feasibility of using “FDT-64” in combination with SAP not only in for the diagnosis of the early-stage of glaucoma, but also in assessing its course. The sensitivity level of the results of “FDT-64” (100 %) compared to “FDT-16” (88 %) in patients with POAG was higher, therefore, “FDT-64” is advisable to use in complex diagnostic cases and in monitoring glaucoma.

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Visual Field Tests for Glaucoma Patients With Initial Macular Damage: Comparison Between Frequency-doubling Technology and Standard Automated Perimetry Using 24-2 or 10-2 Visual Fields

Abstract: We found the detection rate of functional depression related to early macular damage were significant using FDT and parameters of SAP significantly predicted the degree of mGC/IPL thinning in glaucoma patients.

Cited by 7 publications

References 30 publications

Comparing isolated-check visual evoked potential, pattern visual evoked potential, and standard automated perimetry in dysthyroid optic neuropathy eyes

Comparing isolated-check visual evoked potential, pattern visual evoked potential, and standard automated perimetry in dysthyroid optic neuropathy eyes

Investigation of progression pattern and associated risk factors in glaucoma patients with initial paracentral scotomas using Humphrey 10-2

Assessment of the Effectiveness of Different Variants of Frequency Doubling Technology Perimetry in Monitoring the Glaucoma Process

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