Visual function after strontium‐90 plaque irradiation in patients with age‐related subfoveal choroidal neovascularization

Abstract

ABSTRACT.Purpose: To report 2-year visual and angiographic results in eyes treated with strontium plaque irradiation for subfoveal choroidal neovascular membranes (CNVM) in age-related macular degeneration.

Contrast sensitivity as an outcome measure in patients with subfoveal choroidal neovascularisation due to age-related macular degeneration

“…56 However, there was a significant benefit in terms of the percentage of patients with a loss of at least 0.3 log units of contrast sensitivity (representing a halving of the contrast threshold from the baseline value) at 24 months. Positive contrast sensitivity findings have also been reported in small-scale studies of radiation therapy, 57 although other studies, including the largest controlled trial of radiation therapy to date, have reported no significant benefits. 58,59 Other treatment modalities A variety of surgical techniques have been investigated for patients with neovascular AMD.…”

Grading Choroidal Neovascular Membrane Regression after Strontium Plaque Radiotherapy; Masked Subjective Evaluation vs Planimetry

“…We studied the baseline, 3, 6, and 12-month fluorescein angiograms (FA) and fundus photographs of 19 consecutive patients treated in the setting of a pilot study of 90 Sr plaque irradiation for subfoveal CN-VM. Details of the treatment and visual and clinical results have been described elsewhere (13,14). Thirteen of the CNVMs were of the classic type, 4 were occult and 2 included a subfoveal hemorrhagic component.…”

“…In such a situation, grading the angiographic response to treatment is more difficult. We recently performed a pilot study on the feasibility of strontium-90 ( 90 Sr) plaque irradiation in the treatment of exudative AMD (13,14). Here we compare masked subjective evaluation of the angiographic response to a planimetry-based approach for grading regression of the CNVM after irradiation.…”