Visual function assessed by visually evoked potentials in optic pathway low-grade gliomas with and without neurofibromatosis type 1

Dotto, Patrícia de Freitas; Berezovsky, Adriana; Cappellano, Andréa; Silva, Nasjla Saba da; Sacai, Paula Yuri; Silva, Frederico Adolfo B.; Rocha, Daniel; Salomão, Solange Rios

doi:10.1007/s10633-018-9635-0

Cited by 6 publications

(9 citation statements)

References 63 publications

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“…For instance, abnormal VEPs in NFl children were detected prior to visible tumor changes using MRI and before clinical symptoms arose, suggesting that the inclusion of VEPs in the diagnostic protocol together with MRI was relevant [2]. More recently, Dotto• and colleagues (13] showed a reduction of the PlO0 amplitude and a peak time delay of the same component using full-field transient pattern-reversa! VEPs in patients with optic pathway low-grade gliomas.…”

Section: Discussionmentioning

confidence: 99%

“…A different reversa! rate may have been more adequate and perhaps transient VEPs may be the necessary alternative, as a recent study has successfully measured the full visual field of patients using transient level frequencies [13]. Nonetheless, additional research is needed to confrrm this result and assess various testing parameters that could effectively identify both central and peripheral VF integrity simultaneously while using steady-state stimulation.…”

Section: Discussionmentioning

confidence: 99%

“…lndeed, some studies use a uniform flickering field presented in a mini-ganzfeld VEPs [35,36], others use field-specific VEPs [19, ~7], multifocal VEPs [38], and full-field pattern-reversa! VEPs [2,13].…”

Section: Discussionmentioning

confidence: 99%

“…VEPs in patients with optic pathway low-grade gliomas. In these studies, the visual stimulation involved central, paracentral and near-peripheral VF (17 x 17 degrees in (13] and 38 x 38 degrees in [2]). Our results support the notion that the central/paracentral region is likely the most efficient VF stimulation to detect visual alterations in OPG patients.…”

Section: Discussionmentioning

confidence: 99%

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Central and peripheral steady-state visual evoked potentials in children with optic pathway gliomas

et al. 2019

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Optic Pathway Gliomas (OPG) represent 4-6% of brain tumors in children. Treatment of optic pathway gliomas is prompted by neuroradiological evidence of tumor growth, usually associated with progressive visual loss. Despite therapy, approximately 40% will show visual deterioration. Treatment outcome is largely based on the preservation of vision. However, current visual fonction assessment is often unreliable in children with optic pathway gliomas who have limited collaboration. Thus, there is a need for new clinical tools to evaluate visual functions in these children. The_aim of the study was to assess the usefulness of steady-state visual evoked potentials as a tool to assess the integrity of the central and peripheral visual fields of children with optic pathway gliomas.Ten patients with optic pathway gliomas and 33 healthy controls (ages 3 to• 18 years) were tested using steady-state visual evoked potentials. The circular dart-board stimulus consisted of one central circle altemating at 16 reversals/second and one peripheral hoop alternating at 14.4 reversals/second, separated by ahoop of gray space. It was presented Iilonocularly at 30% and 96% contrasts.Results indicated that central signal-to-noise ratios were significantly lower in children with optic pathway gliomas compared to controls. However, no significant group difference was detected in the peripheral visual field.In conclusion, our study shows that steady-state visual evoked potentials could be useful in the clinical assessment and follow up of central visual • field deficits in uncooperative or non-verbal children but seems to have limited usefulness for the evaluation of peripheral visual field defièits. Additional studies are needed to identify • . testing parameters for full visual-field assessment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Central and peripheral steady-state visual evoked potentials in children with optic pathway gliomas

et al. 2019

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“…19 Checkerboard patternreversal VEPs (PRVEP) are linked to activation of particular retinotopic fields in V1 by time-locked contrast-based stimuli, whereas flash VEP (FVEP) expresses massive cortical enhancement by luminance variation. 20 The well-established importance of VEPs in neuro-ophthalmological settings includes evaluation of the optic pathways threatened by neoplastic lesions, [21][22][23][24][25][26][27][28][29] intraoperative monitoring, 27,[30][31][32] and post-resection. 3,22,30,31 Of particular interest is the opportunity to evaluate visual function in neuro-oncologic patients with media opacities, poor cooperation, non-verbal, or unable to provide reliable information on psychophysical testing.…”

Section: Introductionmentioning

confidence: 99%

Visual function assessed by visually evoked potentials in adults with orbital and other primary intracranial tumors

Dotto

Berezovsky

Sacai

et al. 2020

European Journal of Ophthalmology

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Purpose: The purpose of this study was to assess visual function by visually evoked potentials in adults with orbital and other primary brain tumors affecting the optic pathway. Methods: In this retrospective case–control series, patients with orbital (intraconal and extraconal) or midline/chiasmatic tumors were included. Visually evoked potentials using pattern-reversal visually evoked potential and flash visually evoked potential stimuli were performed according to the international standards. Outcome measures were visually evoked potential parameters of amplitude (µV) and peak times (ms) measured both for the P100 component (pattern-reversal visually evoked potentials) and the N2P2 complex (flash visually evoked potential). Individual results were also compared with gender-based normative values. Results: A group of 21 adult patients (17 females) and age- and sex-matched controls were evaluated. Tumor location was intraconal (6 meningiomas, 3 hemangiomas, 1 glioma), extraconal (6 meningiomas), and midline (3 pituitary adenomas, 2 hypothalamic/chiasmatic low-grade gliomas). Abnormal fundus (76%), abnormal pupillary reflexes (71%), reduced visual acuity (62%), strabismus (48%), and proptosis (38%) were present. Visually evoked potential abnormalities were found in at least one eye of all cases. Affected eyes had significantly reduced amplitudes and prolonged peak times for pattern-reversal visually evoked potentials ( p < .001) and significantly reduced amplitudes for flash visually evoked potential ( p < .001). In unilateral orbital tumors, abnormally prolonged pattern-reversal visually evoked potential peak times were also detected in some contralateral eyes ( n = 6/16). Conclusion: Visually evoked potential abnormalities were found in all adult patients with orbital and other intracranial primary tumors, even in eyes with normal exam and good visual acuity. Visually evoked potential can be used as a non-invasive ancillary test to characterize and monitor visual function in subjects with these neoplastic lesions.

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Clinical electrophysiology of the optic nerve and retinal ganglion cells

Marmoy

Viswanáthan

2021

Eye

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Clinical electrophysiological assessment of optic nerve and retinal ganglion cell function can be performed using the Pattern Electroretinogram (PERG), Visual Evoked Potential (VEP) and the Photopic Negative Response (PhNR) amongst other more specialised techniques. In this review, we describe these electrophysiological techniques and their application in diseases affecting the optic nerve and retinal ganglion cells with the exception of glaucoma. The disease groups discussed include hereditary, compressive, toxic/nutritional, traumatic, vascular, inflammatory and intracranial causes for optic nerve or retinal ganglion cell dysfunction. The benefits of objective, electrophysiological measurement of the retinal ganglion cells and optic nerve are discussed, as are their applications in clinical diagnosis of disease, determining prognosis, monitoring progression and response to novel therapies.

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Visual function assessed by visually evoked potentials in optic pathway low-grade gliomas with and without neurofibromatosis type 1

Cited by 6 publications

References 63 publications

Central and peripheral steady-state visual evoked potentials in children with optic pathway gliomas

Central and peripheral steady-state visual evoked potentials in children with optic pathway gliomas

Visual function assessed by visually evoked potentials in adults with orbital and other primary intracranial tumors

Clinical electrophysiology of the optic nerve and retinal ganglion cells

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