Visual Functions Affecting Vision-Related Quality of Life Following Intravitreal Ranibizumab Therapy for Central Retinal Vein Occlusion

Abstract

Visual functions that affect vision-related quality of life (VR-QoL) before and after intravitreal injection of ranibizumab in patients with cystoid macular edema secondary to central retinal vein occlusion (CRVO-CME) are poorly understood. This multicenter, open-label, single-arm prospective study included 23 treatment-naïve patients with CRVO-CME. The best-corrected visual acuity (BCVA), letter contrast sensitivity (LCS), severity of metamorphopsia (M-CHARTS), amount of aniseikonia (New Aniseikonia Test), and stereopsis (Titmus Stereo Test and TNO stereotest) were examined every month from before treatment to 12 months after treatment. For VR-QoL assessment, the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) was provided to the patients before treatment and at 3, 6, and 12 months after treatment. Stepwise multiple regression analysis revealed that the BCVA of the fellow eye was related to the VFQ-25 composite score before treatment, and that the BCVA of the fellow eye and TNO values were related to the VFQ-25 composite score 12 months after treatment. Changes in LCS were significantly correlated with changes in the VFQ-25 composite score. In patients with CRVO-CME, visual acuity of the fellow eye had the strongest impact on VR-QoL. The contrast sensitivity of the affected eye and stereopsis were also associated with VR-QoL.

Impact of Routinely Performed Optical Coherence Tomography Examinations on Quality of Life in Patients with Retinal Diseases—Results from the ALBATROS Data Collection

“…This observation could be explained by the fact that the fellow eye had good and stable vision in most of these cases. Previous studies have shown that the visual acuity of the better eye has a high impact on VRQoL, although lower visual acuity in the fellow eye also shows an impact on VRQoL [ 22 , 23 ]. It is possible that worsening of visual acuity of a fellow eye, whose visual acuity was initially better than the study eye, leads to better adherence due to the fellow eye including more follow-up evaluations at the particular OCT visits.…”

Analyze of factors and prognosis of eyes lost to follow-up in retinal vein occlusive disease patients receiving anti-vascular endothelial growth factor therapy

“…The visual outcome and anatomical morphology improvement may have prevented this patient group from continuing to LTFU. Despite the resolution of macular edema and restoration of anatomical morphology, the majority of patients (72.7%) did not seek further medical attention due to the lack of improvement in their vision, which could be attributed to the reduced contrast sensitivity and stereo vision in the affected eye following anti-VEGF treatment[ 23 , 24 ]. However, 50% of the patients still had varying degrees of complications, resulting in vision deterioration and return to the clinic.…”