Visual hallucinations in Parkinson’s disease are associated with thinning of the inner retina

Visser, Femke; Apostolov, Valentin; Vlaar, Annemarie; Twisk, Jos W. R.; Weinstein, Henry C.; Berendse, Henk W.

doi:10.1038/s41598-020-77833-1

Cited by 11 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, the frontostriatal syndrome does not predict PDD, whereas PC syndrome does. 42 43 In this context, some biomarkers could help us to understand the origin of these complications in patients with PD, 30 41 44 45 46 but we did not detect differences in the SB analysis. Although previous studies found that SCC were an independent predictor of MCI development in CN patients with PD, 10 11 47 only persistent SCC were associated with CI in our study when no other covariates were considered.…”

Section: Discussionmentioning

confidence: 63%

Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints

et al. 2023

View full text Add to dashboard Cite

Background and Purpose Visual hallucinations (VH) and subjective cognitive complaints (SCC) are associated with cognitive impairment (CI) in Parkinson’s disease. Our aims were to determine the association between VH and SCC and the risk of CI development in a cohort of patients with Parkinson’s disease and normal cognition (PD-NC). Methods Patients with PD-NC (total score of >80 on the Parkinson’s Disease Cognitive Rating Scale [PD-CRS]) recruited from the Spanish COPPADIS cohort from January 2016 to November 2017 were followed up after 2 years. Subjects with a score of ≥1 on domain 5 and item 13 of the Non-Motor Symptoms Scale at baseline (V0) were considered as “with SCC” and “with VH,” respectively. CI at the 2-year follow-up (plus or minus 1 month) (V2) was defined as a PD-CRS total score of <81. Results At V0 ( n =376, 58.2% males, age 61.14±8.73 years [mean±SD]), the frequencies of VH and SCC were 13.6% and 62.2%, respectively. VH were more frequent in patients with SCC than in those without: 18.8% (44/234) vs 4.9% (7/142), p <0.0001. At V2, 15.2% (57/376) of the patients had developed CI. VH presenting at V0 was associated with a higher risk of CI at V2 (odds ratio [OR]=2.68, 95% confidence interval=1.05–6.83, p =0.0.039) after controlling for the effects of age, disease duration, education, medication, motor and nonmotor status, mood, and PD-CRS total score at V0. Although SCC were not associated with CI at V2, presenting both VH and SCC at V0 increased the probability of having CI at V2 (OR=3.71, 95% confidence interval=1.36–10.17, p =0.011). Conclusions VH were associated with the development of SCC and CI at the 2-year follow-up in patients with PD-NC.

show abstract

Section: Discussionmentioning

confidence: 63%

Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Lee et al (2014) identified RNFL thinning among the PD subgroups, and noted that RNFL thickness is thinnest in groups without dementia, suggesting RNFL thinning was associated with the occurrence of VH in PD. Similarly, a recent report confirmed the relationship between RNFL thinning and the presence of VH, revealing that individuals with VH had a thinner GCL-IPL than individuals without VH (Visser et al, 2020). It is believed that the old age, disease's duration, motor disorders, and other non-motor disturbances could worsen the VH as the risk factors in PD (Fénelon et al, 2000;Zhu et al, 2013).…”

Section: Visual Hallucinationsmentioning

confidence: 77%

“…Evidence has demonstrated a significant positive correlation between lower visual acuity and thinning RNFL thickness (Satue et al, 2017;Visser et al, 2020;Abd Hamid et al, 2021; Table 3). Sparkly, the thinness in the ganglion cell-inner plexiform layer in PD was strongly correlated with low contrast visual acuity via a comprehensive battery of visual function tests (Murueta-Goyena et al, 2019;Marrocco et al, 2020).…”

Section: Visual Acuitymentioning

confidence: 99%

“…Based on a hypothesis of VH titled the Charles Bonnet syndrome (Stebbins et al, 2004), we know that retinal damage is linked to poor signals in the brain regions, and lead to less visual cortical activation and play a crucial role in the neuropathophysiological function of VH in PD. Moreover, emerging studies stated that defective visual information processing involvement has been demonstrated in VH of PD patients, so retinal impairment appears to be one of mechanisms of the sign (Visser et al, 2020).…”

Section: Visual Hallucinationsmentioning

confidence: 99%

See 1 more Smart Citation

Retinal Degeneration: A Window to Understand the Origin and Progression of Parkinson’s Disease?

Zhang

Yue

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, manifests with motor and non-motor symptoms associated with two main pathological hallmarks, including the deterioration of dopaminergic cells and aggregation of alpha-synuclein. Yet, PD is a neurodegenerative process whose origin is uncertain and progression difficult to monitor and predict. Currently, a possibility is that PD may be secondary to long lasting peripheral affectations. In this regard, it has been shown that retinal degeneration is present in PD patients. Although it is unknown if retinal degeneration precedes PD motor symptoms, the possibility exists since degeneration of peripheral organs (e.g., olfaction, gut) have already been proven to antedate PD motor symptoms. In this paper, we explore this possibility by introducing the anatomical and functional relationship of retina and brain and providing an overview of the physiopathological changes of retinal structure and visual function in PD. On the basis of the current status of visual deficits in individuals with PD, we discuss the modalities and pathological mechanism of visual function or morphological changes in the retina and focus on the correlation between visual impairment and some representative structural features with clinical significance. To consider retinal degeneration as a contributor to PD origin and progress is important because PD evolution may be monitored and predicted by retinal studies through state-of-the-art techniques of the retina. It is significant to integrally understand the role of retinal morphological and functional changes in the neurodegenerative process for the diagnosis and therapeutic strategies of PD.

show abstract

“…We also could not find a correlation between IPL thickness and cognition. However, a few previous publications reported a significant correlation between the GCL-IPL and MoCA [53,54]. One longitudinal study reported an increased risk of cognitive decline after three years of follow-up of PD patients with a lower RNFL and GCL-IPL thickness at baseline [53].…”

Section: Correlation Analysesmentioning

confidence: 99%

Reduced Thickness of the Retina in de novo Parkinson’s Disease Shows A Distinct Pattern, Different from Glaucoma

Chrysou,

Heikka,

van der Zee

et al. 2024

Journal of Parkinson’s Disease

View full text Add to dashboard Cite

Background: Parkinson’s disease (PD) patients experience visual symptoms and retinal degeneration. Studies using optical coherence tomography (OCT) have shown reduced thickness of the retina in PD, also a key characteristic of glaucoma. Objective: To identify the presence and pattern of retinal changes in de novo, treatment-naive PD patients compared to healthy controls (HC) and early primary open angle glaucoma (POAG) patients. Methods: Macular OCT data (10×10 mm) were collected from HC, PD, and early POAG patients, at the University Medical Center Groningen. Bayesian informative hypotheses statistical analyses were carried out comparing HC, PD-, and POAG patients, within each retinal cell layer. Results: In total 100 HC, 121 PD, and 78 POAG patients were included. We showed significant reduced thickness of the inner plexiform layer and retinal pigment epithelium in PD compared to HC. POAG patients presented with a significantly thinner retinal nerve fiber layer, ganglion cell layer, inner plexiform layer, outer plexiform layer, and outer photoreceptor and subretinal virtual space compared to PD. Only the outer segment layer and retinal pigment epithelium were significantly thinner in PD compared to POAG. Conclusions: De novo PD patients show reduced thickness of the retina compared to HC, especially of the inner plexiform layer, which differs significantly from POAG, showing a more extensive and widespread pattern of reduced thickness across layers. OCT is a useful tool to detect retinal changes in de novo PD, but its specificity versus other neurodegenerative disorders has to be established.

show abstract

Visual hallucinations in Parkinson’s disease are associated with thinning of the inner retina

Cited by 11 publications

References 30 publications

Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints

Risk of Cognitive Impairment in Patients With Parkinson’s Disease With Visual Hallucinations and Subjective Cognitive Complaints

Retinal Degeneration: A Window to Understand the Origin and Progression of Parkinson’s Disease?

Reduced Thickness of the Retina in de novo Parkinson’s Disease Shows A Distinct Pattern, Different from Glaucoma

Contact Info

Product

Resources

About