Objective: Refractive errors are most common ocular disorders among children and adolescents. They remain as secondary causes of avoidable blindness in impoverished areas in Africa, most notably in Ethiopia. The problem worsens if it is not managed and addressed early. The aim of this systematic review and meta-analysis was to determine the prevalence of refractive errors among school students in Ethiopia. Methods: We searched international databases such as PubMed/Medline, Web of Science, CINAHL, Embase, Scopus, Cochrane Library, Google Scholar, and Science Direct for relevant articles. Data were extracted using Microsoft Excel and exported to Stata version 14.0 software for analysis. The Cochrane Q and I2 tests were used to assess heterogeneity. Funnel plot, Egger’s, and Begg’s tests were used to assess reporting bias. Random effect meta-analysis model was employed to estimate pooled prevalence of refractive errors. A regional subgroup analysis was carried out. Results: We reviewed 22 qualified studies with 23,355 study participants. The overall prevalence of refractive errors among school students was 7.36% (95% confidence interval = 6.05, 8.67). The prevalence of myopia, hyperopia, and astigmatism was 5.10% (95% confidence interval = 3.79, 6.40), 0.95% (95% confidence interval = 0.59, 1.31), and 0.01% (95% confidence interval = 0.01, 0.04), respectively. From subgroup analysis, the highest prevalence of refractive errors was reported in Amhara Region (9.18%, 95% confidence interval = 6.63, 11.74), followed by Southern Nations, Nationalities, and Peoples’ region (6.78%, 95% confidence interval = 4.65, 8.92) while the lowest prevalence of refractive errors was reported in Addis Ababa (3.93%, 95% confidence interval = 3.30, 4.56). Conclusion: In Ethiopia, the prevalence of refractive errors among school students is higher (7.36%) compared to what it was 5 years (7.05%) ago. Amhara Region has the highest prevalence of refractive errors among school students in Ethiopia with myopia being the most common type of refractive error.