Visual Learning Deficits in Nonresected Patients with Right Temporal Lobe Epilepsy

Helmstaedter, Christoph; Pohl, C.; Hufnagel, A.; Elger, Christian E.

doi:10.1016/s0010-9452(13)80004-4

Cited by 170 publications

(111 citation statements)

References 11 publications

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“…In patients with unilateral TLE, the side-of-lesion/epilepsy focus determines the pattern of memory deficits (Milner, 1968); dominant (usually left) TLE has been associated with impaired verbal memory (Helmstaedter & Elger, 1998;Helmstaedter, Grunwald, Lehnertz, Gleißner, & Elger, 1997;Hermann, Seidenberg, Schoenfeld, & Davies, 1997;Sass et al, 1995), whereas non-dominant (usually right) TLE tends to affect visual memory (Barr, 1997;Baxendale, Thompson, & Paesschen, 1998;Breier et al, 1996;Helmstaedter, Pohl, Hufnagel, & Elger, 1991;Smith, Bigel, & Miller, 2011). The roles of the left and the right temporal lobes have been less clearly delineated for recall of personally experienced events in patients with unilateral TLE, with some studies indicating deficits in patients with left TLE (LTLE) (Leeman, Macklin, Schomer, & O'Connor, 2009;Voltzenlogel et al, 2006), and others finding deficits in patients with right TLE (RTLE; Lah et al, 2006;Munera et al, 2014).…”

Section: Design Prospective Cross-sectionalmentioning

confidence: 99%

Imagining future events in patients with unilateral temporal lobe epilepsy

Lechowicz

Miller

Irish

et al. 2016

British J Clinic Psychol

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Patients with temporal lobe epilepsy generate less details when asked to describe past and potential future events, particularly with regard to details involving specific events, places and perceptions. These same patients are aware of their difficulties in this realm, but judge their past memories as similar in vividness and even more personally significant than the memories generated by control participants. The deficits in generation of future episodic details were particularly pronounced in patients with left temporal lobe epilepsy. Verbal semantic fluency was correlated with the ability to generate future scenarios.

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Section: Design Prospective Cross-sectionalmentioning

confidence: 99%

Imagining future events in patients with unilateral temporal lobe epilepsy

Lechowicz

Miller

Irish

et al. 2016

British J Clinic Psychol

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“…Nonverbal figural memory was assessed by the revised version of the Diagnosticum für Cerebralschädigung (DCS-R) [37]. The test requires learning and reconstruction of 9 abstract designs in 5 consecutive trials.…”

Section: Pre-and Postoperative Memory Assessmentmentioning

confidence: 99%

“…The considered measures were the number of correctly learned designs over 5 learning trials and recognition performance (corrected for false-positive answers). The test has been shown to be sensitive to right temporal lobe dysfunction, right mesiotemporal pathology, and also to right-sided temporal lobe surgery [36][37][38][39].…”

Section: Pre-and Postoperative Memory Assessmentmentioning

confidence: 99%

Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy

et al. 2015

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Surgical treatment of unilateral mesial temporal lobe epilepsy (mTLE) particularly bears the risk of episodic memory decline. The present study investigates the role of the ipsilateral hippocampal integrity for postoperative change in material-specific memory performance. In 104 patients who had undergone epilepsy surgery for unilateral mTLE, we analyzed pre- to postoperative changes of verbal and figural memory as a function of segmental neuronal cell densities of the resected hippocampus (cornu ammonis, CA1-4; internal and external limb of the dentate gyrus, DG). Results were controlled for side of surgery and hemispheric dominance. Surgery caused significant memory decline, especially with regard to verbal memory after left temporal resections. Seizure freedom (65 % Engel Ia) did not affect memory outcome. Higher neuronal cell densities of the resected left hippocampus were associated with greater declines in verbal memory parameters (r = -0.27 to r = -0.39, p < 0.05), especially when excluding patients with atypical hemispheric dominance (r = -0.34 to r = -0.60, p < 0.05; significant correlations across all hippocampal subfields). There were no systematic correlations between neuronal cell densities of the resected right hippocampus and memory changes. The results emphasize the role of the structural and functional integrity of the hippocampus within the left dominant hemisphere for the degree of verbal memory decline after temporal lobe surgery. Presurgical verbal memory performance may be taken as a marker of ipsilateral left hippocampal integrity and may contribute to individual risk-benefit evaluations before epilepsy surgery. Finally, more precise neuropsychological markers of right hippocampal integrity are needed.

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“…Nonverbal memory was assessed by a revised 5-trial version of the Diagnosticum für Cerebralschädigung (DCS-R). 24,35 The number of correctly reproduced items in the last learning trial was the measure used as being most representative for total performance in this test. For the assessment of executive functions, a phonemic verbal fluency task 33 and a response inhibition task 36 were applied.…”

Section: Neuropsychological Assessmentmentioning

confidence: 99%

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

Vogt¹,

Malter²,

Schoene-Bake³

et al. 2014

JNS

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Object. The purpose of this study was to retrospectively assess the objective and subjective neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis (AHS).Methods. Memory and executive functions were evaluated at baseline and at follow-up in 11 surgically treated patients and compared with 8 pharmacologically treated patients with temporal lobe epilepsy and bilateral AHS. The median follow-up duration was 16 months in the surgically treated patients and 80.5 months in the pharmacologically treated group. Subjective outcome was evaluated by questionnaires and included mood, quality of life, subjective memory, and activities of daily living.Results. At the follow-up assessment, 82% of the surgically treated patients as opposed to 0% of the nonsurgery patients were seizure free. In the surgical group, nonverbal memory performance did not change significantly in any patient after surgery, but there was a floor effect in 55% of the surgical patients. Regarding verbal memory, 9% of the surgical patients improved while 73% declined, despite severe impairments already evident at baseline. In the nonsurgery control group, 13% of the patients declined in nonverbal memory (floor effect in 63%) and 25% declined in verbal memory (floor effect in 25%) at follow-up. None of the controls improved at follow-up. Executive functions remained unchanged on an impaired level in both groups. At follow-up, the patient groups did not differ significantly with respect to mood, quality of life, subjective memory, or activities of daily living. However, in most aspects, surgically treated patients reported a slightly better subjective outcome than pharmacologically treated patients and a significantly improved quality of life.Conclusions. These results suggest that beyond benefits concerning seizure control, surgically treated patients with bilateral AHS, despite already poor baseline performance, are still at risk for severe postoperative decline in memory. In the light of predominantly minor benefits on a subjective level, the findings put the overall outcome of epilepsy surgery in bilateral AHS patients into perspective. (http://thejns.org/doi/abs/10.3171/2014.7.JNS132037) key WordS • neuropsychological outcome • temporal lobe epilepsy surgery • memory • bilateral Ammon's horn sclerosis Abbreviations used in this paper: AHS = Ammon's horn sclerosis; BDI = Beck Depression Inventory; QOLIE = Quality of Life in Epilepsy Inventory; RCI = reliable change index; TLE = temporal lobe epilepsy; VLMT = Verbaler Lern-und Merkfähigkeitstest.

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Visual Learning Deficits in Nonresected Patients with Right Temporal Lobe Epilepsy

Cited by 170 publications

References 11 publications

Imagining future events in patients with unilateral temporal lobe epilepsy

Imagining future events in patients with unilateral temporal lobe epilepsy

Relevance of hippocampal integrity for memory outcome after surgical treatment of mesial temporal lobe epilepsy

Neuropsychological outcome after epilepsy surgery in patients with bilateral Ammon's horn sclerosis

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