“…Clinically, several materials, including air, sulphur hexafluoride (SF 6 ), perfluoropropane (C 3 F 8 ), perfluorocarbon liquids, silicone oil, and heavy silicone oil are commonly used as temporary vitreous substitutes. Although these substitutes have some important characteristics, such as optical clarity and chemical inertness, they are also associated with many drawbacks and limitations, such as elevating intraocular pressure (IOP) and fast intraocular absorption1, post-operative cataract, oil emulsification, secondary glaucoma and keratopathy23456, irreversible cell damage7, higher ametropia89, creating non-effective tamponade if the inferior retina breaks1011, and so on.…”