Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment

Savier, Élise; Reber, Michaël

doi:10.3389/fncel.2018.00077

Cited by 3 publications

(2 citation statements)

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“…To gain insight into the molecular mechanisms involved in map formation, mouse genetic models were generated, in which the expression of members of the Eph and ephrin family was manipulated. The mapping mechanisms of the nasal-temporal axis of the retina onto the rostral-caudal axis of the SC involving Epha/Efna signaling have been, by far, the most studied experimentally ( Feldheim et al, 1998 ; Brown et al, 2000 ; Feldheim et al, 2000 ; Reber et al, 2004 ; Rashid et al, 2005 ; Pfeiffenberger et al, 2006 ; Triplett et al, 2009 ; Bevins et al, 2011 ; Suetterlin and Drescher, 2014 ; Owens et al, 2015 ; Savier et al, 2017 ; Savier and Reber, 2018 ). Several hypotheses have been made to account for the phenotypes observed in mouse genetic models and this extensive body of work has been used to generate computational approaches which attempt to replicate experimental findings ( Honda, 2003 ; Reber et al, 2004 ; Honda, 2004 ; Koulakov and Tsigankov, 2004 ; Goodhill and Xu, 2005 ; Willshaw, 2006 ; Tsigankov and Koulakov, 2006 ; Tsigankov and Koulakov, 2010 ; Triplett et al, 2011 ; Simpson and Goodhill, 2011 ; Grimbert and Cang, 2012 ; Sterratt and Hjorth, 2013 ; Willshaw et al, 2014 ; Hjorth et al, 2015 ; Owens et al, 2015 ; Savier et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

“…The 3-step map alignment model simulates the formation of the RC map and, for the first time, the subsequent formation and alignment of the CC map along the rostral-caudal axis of the SC based on experimental and mechanistic evidence ( Savier et al, 2017 ; Savier and Reber, 2018 ). This algorithm predicts normal wild-type (WT) mapping as well as the map alignment defects observed in the Isl2-Efna3KI animals ( Savier et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

Savier

Dunbar

Cheung

et al. 2020

eLife

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We previously identified and modeled a principle of visual map alignment in the midbrain involving the mapping of the retinal projections and concurrent transposition of retinal guidance cues into the superior colliculus providing positional information for the organization of cortical V1 projections onto the retinal map (Savier et al., 2017). This principle relies on mechanisms involving Epha/Efna signaling, correlated neuronal activity and axon competition. Here, using the 3-step map alignment computational model, we predict and validate in vivo the visual mapping defects in a well-characterized mouse model. Our results challenge previous hypotheses and provide an alternative, although complementary, explanation for the phenotype observed. In addition, we propose a new quantification method to assess the degree of alignment and organization between maps, allowing inter-model comparisons. This work generalizes the validity and robustness of the 3-step map alignment algorithm as a predictive tool and confirms the basic mechanisms of visual map organization.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

Savier

Dunbar

Cheung

et al. 2020

eLife

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Identification of ocular regulatory functions of core histone variant H3.2

Vetrivel¹,

Truong

Wurst

et al. 2023

Experimental Eye Research

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New insights on the modelling of the molecular mechanisms underlying neural maps alignment in the midbrain

Savier

Dunbar

Cheung

et al. 2020

Preprint

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16We previously identified and modelled a principle of visual maps alignment in the midbrain 17 involving the mapping of the retinal projections and concurrent transposition of retinal guidance 18 cues into the superior colliculus providing positional information for the organization of cortical V1 19 projections onto the retinal map . This principle relies on mechanisms involving 20 Epha/Efna signaling, correlated neuronal activity and axon competition. Here, using the 3-step 21 map alignment computational model, we predict and validate in vivo the visual mapping defects in 22 a well-characterized mouse model. Our results challenge previous hypotheses and provide an 23 alternative, although complementary, explanation for the phenotype observed. In addition, we 24 propose a new quantification method to assess the degree of alignment and organization between 25 maps, allowing inter-model comparisons. This work generalizes the validity and robustness of the 26 3-step map alignment algorithm as a predictive tool and confirms the basic mechanisms of visual 27 maps organization. Savier and Reber, 56 2018). Several hypotheses have been made to account for the phenotypes observed in mouse 57 genetic models and this extensive body of work has been used to generate computational 58 approaches which attempt to replicate experimental findings 62 Savier et al., 2017). However, until recently, these models have not been able to explain how 63 collicular visual maps are aligned during development. 64Interestingly, the formation of the retino-collicular map occurs prior to the establishment of the 65 cortico-collicular map. Other studies have shown that the existence of the retino-collicular map is 66 necessary for the formation of the cortico-collicular map, suggesting an interdependence of the 67 two mechanisms (Khachab and Bruce, 1999;Rhoades et al., 1985;Triplett et al., 2009). Similar 68 observations have been made in other part of the visual system (Shanks et al., 2016). Another 69 piece of evidence came from the study of map alignment in the Isl2-Epha3KI, one of the best 70 characterized mutant in the field. In these mutants, the Epha3 receptor is ectopically expressed in 71 50% of RGCs, leading to a duplication of the retino-collicular map . Strikingly, 72 a full duplication of the cortico-collicular map is also observed in the Isl2-Epha3 KI/KI homozygous 73 mutants, which display a normal retinotopy in the visual cortex (Triplett et al., 2009). The authors 74 concluded that a retinal-matching mechanism involving spontaneous correlated activity in the 75 retina instructs cortico-collicular projections and alignment onto the retino-collicular map. 76Alternative explanations can also be suggested. For instance, the ectopic expression of Epha3 77 specifically in the retina may alter the expression of other members of Epha/Efna throughout the 78 visual system disrupting maps formation and alignment. In another example, molecular cues 79 originating from the retina could be carried over to the colliculus and provide mapping/...

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Visual Maps Development: Reconsidering the Role of Retinal Efnas and Basic Principle of Map Alignment

Cited by 3 publications

References 45 publications

New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

New insights on the modeling of the molecular mechanisms underlying neural maps alignment in the midbrain

Identification of ocular regulatory functions of core histone variant H3.2

New insights on the modelling of the molecular mechanisms underlying neural maps alignment in the midbrain

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