Visual naked-eye detection of SARS-CoV-2 RNA based on covalent organic framework capsules

Abstract

Graphical abstract

Electrochemiluminescent nanostructured DNA biosensor for SARS-CoV-2 detection

“…Moreover, the detection limit is comparable or even better and the developed biosensor is a simple, easy platform for SARS-CoV-2 detection. On the other hand, compared with other simple methodologies as colorimetric assay [ 33 ], the proposed biosensor present lower detection limit, proving that it can be a simple great practical alternative for detecting SARS-CoV-2 at very low concentrations.…”

An electrochemical biosensor for SARS-CoV-2 detection via its papain-like cysteine protease and the protease inhibitor screening

“…At present, various approaches for SARS-CoV-2 diagnosis have been proposed, which are mainly focused on the detection of SARS-CoV-2 nucleic acid or antibodies [6] , [7] , [8] , [9] , [10] . As the gold standard for nucleic acid detection, real-time quantitative polymerase chain reaction (RT-qPCR) has extremely high sensitivity and specificity, but it has inevitable limitations such as high equipment requirement, time-consumption, and professional technician requirement [11] , [12] .…”

Current trends in COVID-19 diagnosis and its new variants in physiological fluids: Surface antigens, antibodies, nucleic acids, and RNA sequencing

“…The quality and timing of testing are important factors in determining the specificity of the test [ 4 ]. To date, several reports have been published on the development of different analytical methods for the detection of SARS-CoV-2 [ [17] , [18] , [19] , [20] , [21] ]. However, none of these articles comprehensively discussed the detection of SARS-CoV-2 in various body fluids.…”