Visual neglect in posterior cortical atrophy

Andrade, Katia; Samri, Dalila; Sarazin, Marie; Souza, Leonardo Cruz de; Cohen, Laurent; Schotten, Michel Thiebaut de; Dubois, Bruno; Bartolomeo, Paolo

doi:10.1186/1471-2377-10-68

Cited by 57 publications

(38 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…PCA is associated with atrophy in the occipital, parietal, and posterior temporal lobes [106], but recently a lesion of long white-matter tracts, including the superior and inferior longitudinal fasciculi and the inferior fronto-occipital fasciculus, has also been documented [107]. This early-onset AD-related pathology gives rise to complex visuospatial difficulties, such as visuoperceptual impairments [108], optic ataxia, simultanagnosia, gaze apraxia (often with the complete spectrum of Balint syndrome), and even egocentric [109,110] or allocentric [111] unilateral spatial neglect. All such visuospatial impairments have a strong impact on drawing abilities, affecting both spontaneous drawing and copying, and giving rise to severe displacements of drawing elements, omissions, gross spatial distortions ('exploded drawings') [112].…”

Section: Drawing Disabilities In Early and Late Onset Forms Of Admentioning

confidence: 99%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

View full text Add to dashboard Cite

Abstract. Drawing is a multicomponential process that can be impaired by many kinds of brain lesions. Drawing disorders are very common in Alzheimer's disease and other forms of dementia, and can provide clinical information for the distinction of the different dementing diseases. In our review we started from an overview of the neural and cognitive bases of drawing, and from a recollection of the drawing tasks more frequently used for assessing individuals with dementia. Then, we analyzed drawing disorders in dementia, paying special attention to those observed in Alzheimer's disease, from the prodromal stages of the amnesic mild cognitive impairment to the stages of full-blown dementia, both in the sporadic forms with late onset in the entorhino-hippocampal structures and in those with early onset in the posterior neocortical structures. We reviewed the drawing features that could differentiate Alzheimer's disease from vascular dementia and from the most frequent forms of degenerative dementia, namely frontotemporal dementia and Lewy body disease. Finally, we examined some peculiar aspects of drawing disorders in dementia, such as perseverations, rotations, and closing-in. We argue that a careful analysis of drawing errors helps to differentiate the different forms of dementia more than overall accuracy in drawing.

show abstract

Section: Drawing Disabilities In Early and Late Onset Forms Of Admentioning

confidence: 99%

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Trojano

Gainotti

2016

JAD

View full text Add to dashboard Cite

show abstract

“…Redusert oppmerksomhet mot den ene siden av synsfeltet (visuell neglekt) forekommer regelmessig og gir økt risiko for å falle (14). Mange pasienter opplever vansker med bilkjøring og parkering, dels grunnet dårlig avstandsbedømmelse, dels manglende evne til å lokalisere objekter i rommet.…”

Section: Tidlig Stadiumunclassified

“…Neglekt, og det at pasienten bare oppfatter visuelle stimuli i den ene halvdelen av synsfeltet når to stimuli presenteres samtidig i hvert synshalvfelt (visuell ekstinksjon), kan vaere vanskelig å påvise ved tidlig posterior kortikal atrofi på grunn av ledsagende manglende evne til gjenkjennelse/forståelse av visuelle inntrykk (visuell agnosi), til tross for bevart synsskarphet. I senere stadier av sykdommen kan neglekt og visuell ekstinksjon vaere mer fremtredende (1,6,14,17).…”

Section: Senere Stadiumunclassified

See 1 more Smart Citation

Posterior kortikal atrofi

Solyga¹,

Western²,

Solheim³

et al. 2015

Tidsskriftet

View full text Add to dashboard Cite

“…The most frequently cited neuropsychological deficits in PCA are visuospatial and visuoperceptual impairments, alexia and features of Balint's syndrome (simultanagnosia, oculomotor apraxia, optic ataxia, environmental agnosia) and Gerstmann's syndrome (acalculia, agraphia, finger agnosia, left/right disorientation) 15,17,[19][20][21][25][26][27][28][29][30][31] . Working memory deficits and limb apraxia have also been emphasised 20 .…”

Section: Neuropsychological Featuresmentioning

confidence: 99%

Posterior Cortical Atrophy

Delamont

Harrison²,

Field³

et al. 2009

Encyclopedia of Neuroscience

View full text Add to dashboard Cite

Posterior cortical atrophy (PCA) is a neurodegenerative syndrome that is characterized by a progressive decline in visuospatial, visuoperceptual, literacy and praxic skills. The progressive neurodegeneration affecting parietal, occipital and occipito-temporal cortices which underlies PCA is attributable to Alzheimer's disease (AD) in the majority of patients. However, alternative underlying aetiologies including Dementia with Lewy Bodies (DLB), corticobasal degeneration (CBD) and prion disease have also been identified, and not all PCA patients have atrophy on clinical imaging. This heterogeneity has led to diagnostic and terminological inconsistencies, caused difficulty comparing studies from different centres, and limited the generalizability of clinical trials and investigations of factors driving phenotypic variability. Significant challenges remain in identifying the factors associated with both the selective vulnerability of posterior cortical regions and the young age of onset seen in PCA. Greater awareness of the syndrome and agreement over the correspondence between syndrome-and disease-level classifications are required in order to improve diagnostic accuracy, research study design and clinical management.

show abstract

Visual neglect in posterior cortical atrophy

Cited by 57 publications

References 26 publications

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Drawing Disorders in Alzheimer’s Disease and Other Forms of Dementia

Posterior kortikal atrofi

Posterior Cortical Atrophy

Contact Info

Product

Resources

About