Visual object recognition deficits in early Parkinson's disease

Laatu, Sari; Pihko, Laura; Portin, Raija; Rinne, Juha O.

doi:10.1016/j.parkreldis.2004.02.001

Cited by 38 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our paradigm, while VP represented a basic visual perceptual task (21, 22), VS combined both the skill to find the objects’ differences (21, 23) as well as the competence regarding line orientation and shape judgment (21, 24). Therefore, the comparison VS > VP allowed for the subtraction of visual stimulation, visuoperceptual analysis, and motor response, with aim to highlight the specific process underlying visuospatial judgment.…”

Section: Discussionmentioning

confidence: 99%

Subclinical Visuospatial Impairment in Parkinsonâ€™s Disease: The Role of Basal Ganglia and Limbic System

Caproni

Muti²,

Renzo³

et al. 2014

Front. Neurol.

View full text Add to dashboard Cite

Background: Visual perception deficits are a recurrent manifestation in Parkinson’s disease (PD). Recently, structural abnormalities of fronto-parietal areas and subcortical regions, implicated in visual stimuli analysis, have been observed in PD patients with cognitive decline and visual hallucinations. The aim of the present study was to investigate the salient aspects of visual perception in cognitively unimpaired PD patients.Methods: Eleven right-handed non-demented right-sided onset PD patients without visuospatial impairment or hallucinations and 11 healthy controls were studied with functional magnetic resonance imaging while performing a specific visuoperceptual/visuospatial paradigm that allowed to highlight the specific process underlying visuospatial judgment.Results: Significant changes in both cortical areas and subcortical regions involved in visual stimuli processing were observed. In particular, PD patients showed a reduced activation for the right insula, left putamen, bilateral caudate, and right hippocampus, as well as an over-activation of the right dorso-lateral prefrontal and of the posterior parietal cortices, particularly in the right hemisphere.Conclusions: We found that both loss of efficiency and compensatory mechanisms occur in PD patients, providing further insight into the pathophysiological role of the functional alterations of basal ganglia and limbic structures in the impairment of visuoperceptual and visuospatial functions observed in PD.

show abstract

Section: Discussionmentioning

confidence: 99%

Subclinical Visuospatial Impairment in Parkinsonâ€™s Disease: The Role of Basal Ganglia and Limbic System

Caproni

Muti²,

Renzo³

et al. 2014

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…These abilities have been shown to be impaired in PD in laboratory settings. 3,18,36 Inability to recognize traffic signs deprives the driver of key information on upcoming road hazards and safety regulations. 22 Missing a traffic sign may lead to potentially hazardous driving behaviors such as inappropriate speed, missing a turn, or noncompliance with various restrictions.…”

Section: Discussionmentioning

confidence: 99%

Impaired visual search in drivers with Parkinson's disease

Uç¹,

Rizzo²,

Anderson³

et al. 2006

Annals of Neurology

143

156

View full text Add to dashboard Cite

show abstract

Section: Cognitive Deficits In Parkinson's Diseasementioning

confidence: 99%

“…In particular, memory deterioration affects both spatial (Levin 1990) and nonspatial working memory domains (Matison et al 1982), implicit memory (Heindel et al 1989;van Asselen et al 2009), episodic memory, and procedural learning (Dujardin et al 2003), whereas the ability to form new episodic memories is preserved (Knowlton et al 1996;Squire and Zola 1996;Dubois and Pillon 1997). Deficits in visual perception (Levin 1990;Lee et al 1998) and object recognition (Laatu et al 2004) are also frequently reported as one of the earliest symptoms in PD patients, with an apparent independency from the severity of motor dysfunctions, neuropsychiatric complications, and general cognitive deterioration (Girotti et al 1988;Antal et al 1998).The heterogeneity of the cognitive deficits in these patients significantly complicates the clinical diagnosis that is nowadays based on neuropsychological tasks for language (Boston Naming Test), planning and abstract reasoning (Wisconsin Card Sorting test, Tower of London, Wechsler Adult Intelligence Scale [WAIS] similarities), visuospatial abilities (Line Orientation test), freerecall verbal (Rey Auditory Verbal Learning test) and visual memory (Faces Immediate Recognition test), psychomotor speed (Digit Symbol Test), and attention (Digit span backward). However, among them, the memory tasks are the most suitable for PD diagnosis (Muslimovic et al 2005).…”

mentioning

confidence: 99%

Understanding cognitive deficits in Parkinson’s disease: lessons from preclinical animal models

et al. 2013

View full text Add to dashboard Cite

Parkinson's disease (PD) has been, until recently, mainly defined by the presence of characteristic motor symptoms, such as rigidity, tremor, bradykinesia/akinesia, and postural instability. Accordingly, pharmacological and surgical treatments have so far addressed these motor disturbances, leaving nonmotor, cognitive deficits an unmet clinical condition. At the preclinical level, the large majority of studies aiming at defining mechanisms and testing novel therapies have similarly focused on the motor aspects of PD. Unfortunately, deterioration of the executive functions, such as attention, recognition, working memory, and problem solving, often appear in an early, premotor phase of the disease and progressively increase in intensity, negatively affecting the quality of life of 50% -60% of PD patients. At present, the cellular mechanisms underlying cognitive impairments in PD patients are largely unknown and an adequate treatment is still missing. The preclinical research has recently developed new animal models that may open new perspectives for a more integrated approach to the treatment of both motor and cognitive symptoms of the disease. This review will provide an overview on the cognitive symptoms occurring in early PD patients and then focus on the rodent and nonhuman primate models so far available for the study of discriminative and spatial memory attention and learning abilities related to this pathological condition. Cognitive deficits in Parkinson's diseaseParkinson's disease (PD) is a chronic neurodegenerative disorder affecting over four million people worldwide (Dorsey et al. 2007). It is classically characterized by the emergence of motor symptoms such as rigidity, tremor, postural unbalance, and bradykinesia/akinesia (Braak et al. 2003;Jankovic 2008). However, PD also involves nonmotor symptoms (NMS) (Chaudhuri et al. 2006;Jankovic 2008) that appear in the early, often premotor, phase of the disease (Abbott et al. 2005;Abbott 2007;Claassen et al. 2010) and significantly contribute to the impairment of the quality of life of 50%-60% of PD patients (Aarsland et al. 2012). Among others, NMS include olfactory dysfunction, REM sleep disorder, neuropsychiatric disturbances, and cognitive deficits (Schrag et al. 2004;Chaudhuri and Odin 2010). All these symptoms develop independently from each other in the early phase of the disease, and progressively increase in intensity, often leading to dementia in the late phase (Cools et al. 2001;Goetz et al. 2008).Neuropsychiatric mood-related disorders are rather common in PD (Cummings 1992;Schrag et al. 2004) with a prevalence of 20% (Reijnders et al. 2008), and manifest as apathy, depression, and anxiety.On the other hand, cognitive impairments associated with PD are mainly related to the executive functions, resulting in a phenotype resembling that of frontal lobe patients (Robbins and Arnsten 2009), with deficits in attention (Ballard et al. 2002), planning, concept formation, and working memory (Kehagia et al. 2010). In particular, memory deterioration aff...

show abstract

Visual object recognition deficits in early Parkinson's disease

Cited by 38 publications

References 23 publications

Subclinical Visuospatial Impairment in Parkinsonâ€™s Disease: The Role of Basal Ganglia and Limbic System

Subclinical Visuospatial Impairment in Parkinsonâ€™s Disease: The Role of Basal Ganglia and Limbic System

Impaired visual search in drivers with Parkinson's disease

Understanding cognitive deficits in Parkinson’s disease: lessons from preclinical animal models

Contact Info

Product

Resources

About