Visual outcome, local tumour control, and eye preservation after<sup>106</sup>Ru/Rh brachytherapy for choroidal melanoma

Isager, Peter; Ehlers, Niels; Urbak, Steen F.; Overgaard, Jens

doi:10.1080/02841860500468950

Cited by 20 publications

(10 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the consecutive series of patients after Ru106 brachytherapy, patients retained some useful vision in the first postoperative years and a few even got better visual acuity; however, the long-term visual outcome is poor with a continuing visual acuity loss over time. A large number of patients became blind or lost reading ability after 5 years, either because of radiation complications or secondary enucleation (35). According to our results, tumor regression after the single SRS treatment at a 6-month interval in the first year after the therapy showed that in the group of small tumors in all of the cases there was no increase of the elevation; in 24 months, there was tumor regression in 3 cases (75%).…”

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

Furdová

Strmeň

Waczulı́ková

et al. 2011

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

Furdová

Strmeň

Waczulı́ková

et al. 2011

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Thus, the specific underlying causes remain not fully understood, and radiation-induced visual acuity deterioration might originate from several discrete pathophysiologies. Isager et al investigated visual outcomes for 55 patients, and found tumour height and the largest base dimension as the most important risk factors for visual acuity deterioration, but they did not perform multivariate analyses, nor did they include dose in their analysis [12]. According to Bergman et al, initial visual acuity was main risk factor along with the distance from the tumour to the fovea in a study with 579 patients.…”

Section: Discussionmentioning

confidence: 99%

Predicting Visual Acuity Deterioration and Radiation-Induced Toxicities after Brachytherapy for Choroidal Melanomas

Espensen

Appelt

Fog

et al. 2019

Cancers

View full text Add to dashboard Cite

Ruthenium-106 (Ru-106) brachytherapy is an established modality for eye-preserving treatment of choroidal melanoma. To achieve optimal treatment outcomes, there should be a balance between tumour control and the risk of healthy tissue toxicity. In this retrospective study, we examined normal tissue complication probability (NTCP) for visual acuity deterioration and late complications to aid the understanding of dose-dependence after Ru-106 treatments. We considered consecutive patients diagnosed with choroidal melanoma and primarily treated at a single institution from 2005–2014. Treatment plans were retrospectively recreated using dedicated software and image guidance to contour the tumour and determine the actual plaque position. Dose distributions were extracted from each plan for all relevant anatomical structures. We considered visual acuity deterioration and late complications (maculopathy, optic neuropathy, ocular hypertension, vascular obliteration, cataract and retinal detachment). Lasso statistics were used to select the most important variables for each analysis. Outcomes were related to dose and clinical characteristics using multivariate Cox regressions analysis. In total, 227 patients were considered and 226 of those were eligible for analysis. Median potential follow-up time was 5.0 years (95% CI: 4.5–6.0). Visual acuity deterioration was related to optic disc-tumour distance and dose metrics from the retina and the macula, with retina V10Gy showing the strongest correlation. Macula V10Gy was the only dose metric impacting risk of maculopathy, while optic disc-tumour distance also proved important. Optic disc V50Gy had the largest impact on optic neuropathy along with optic disc-tumour distance. Optic disc V20Gy was the only variable associated with vascular obliteration. Lens D2% had the largest impact on the risk of cataract along with older age and the largest base dimension. We found no variables associated with the risk of ocular hypertension and retinal detachment. Visual acuity deterioration and most late complications demonstrated dependence on dose delivered to healthy structures in the eye after Ru-106 brachytherapy for choroidal melanomas.

show abstract

“…These results are very similar to ours. Some authors reported 5-year eye preservation rates of 72-82% [ 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Radiobiological doses, tumor, and treatment features influence on local control, enucleation rates, and survival after epiescleral brachytherapy. A 20-year retrospective analysis from a single-institution: part I

Miguel¹,

Frutos-Baraja²,

López-Lara³

et al. 2018

jcb

View full text Add to dashboard Cite

PurposeTo assess influence of the radiobiological doses, tumor, and treatment features on local control, enucleation rates, overall and disease-specific survival rates after brachytherapy for posterior uveal melanoma.Material and methodsLocal control, enucleation, overall and disease-specific survival rates were evaluated on the base of 243 patients from 1996 through 2016, using plaques loaded with iodine sources. Clinical and radiotherapy data were extracted from a dedicated prospective database. Biologically effective dose (BED) was included in survival analysis using Kaplan-Meier and Cox regressions. The 3-, 5-, 10-, and 15-year relative survival rates were estimated, and univariate/multivariate regression models were constructed for predictive factors of each item. Hazard ratio (HR) and confidence interval at 95% (CI) were determined.ResultsThe median follow-up was 73.9 months (range, 3-202 months). Cumulative probabilities of survival by Kaplan-Meier analysis at 3, 5, 10 and 15 years were respectively: 96%, 94%, 93%, and 87%, for local control; 93%, 88%, 81%, and 73% for globe preservation; 98%, 93%, 84%, and 73% for overall survival, and 98%, 96%, 92%, and 87% for disease-specific survival. By multivariate analysis, we concluded variables as significant: for local control failure – the longest basal diameter and the juxtapapillary location; for globe preservation failure – the longest basal dimension, the mushroom shape, the location in ciliary body, and the dose to the foveola; for disease-specific survival – the longest basal dimension. Some radiobiological doses were significant in univariate models but not in multivariate ones for the items studied.ConclusionsThe results show as predictive factors of local control, enucleation, and disease-specific survival rates those related with the features of the tumor, specifically the longest basal dimension. There is no clear relation between radiobiological doses or treatment parameters in patients after brachytherapy.

show abstract

Visual outcome, local tumour control, and eye preservation after¹⁰⁶Ru/Rh brachytherapy for choroidal melanoma

Cited by 20 publications

References 52 publications

One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

Predicting Visual Acuity Deterioration and Radiation-Induced Toxicities after Brachytherapy for Choroidal Melanomas

Radiobiological doses, tumor, and treatment features influence on local control, enucleation rates, and survival after epiescleral brachytherapy. A 20-year retrospective analysis from a single-institution: part I

Contact Info

Product

Resources

About

Visual outcome, local tumour control, and eye preservation after106Ru/Rh brachytherapy for choroidal melanoma

Cited by 20 publications

References 52 publications

One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

One-Day Session LINAC–Based Stereotactic Radiosurgery of Posterior Uveal Melanoma

Predicting Visual Acuity Deterioration and Radiation-Induced Toxicities after Brachytherapy for Choroidal Melanomas

Radiobiological doses, tumor, and treatment features influence on local control, enucleation rates, and survival after epiescleral brachytherapy. A 20-year retrospective analysis from a single-institution: part I

Contact Info

Product

Resources

About

Visual outcome, local tumour control, and eye preservation after¹⁰⁶Ru/Rh brachytherapy for choroidal melanoma