Visual Outcomes in Treated Bacterial Keratitis: Four Years of Prospective Follow-up

McClintic, Scott M.; Prajna, Namperumalsamy Venkatesh; Srinivasan, Muthiah; Mascarenhas, Jeena; Lalitha, Prajna; Rajaraman, Revathi; Oldenburg, Catherine E.; O’Brien, Kieran; Ray, Kathryn J.; Acharya, Nisha R.; Lietman, Thomas M.; Keenan, Jeremy D.

doi:10.1167/iovs.14-13980

Cited by 28 publications

(14 citation statements)

References 12 publications

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“…The visual outcome associated with treatment success seems to be good for the less severely affected eyes. A follow-up over a longer duration would be interesting to determine whether there is ongoing reduction in corneal opacity, as described in human bacterial keratitis (McClintic et al 2014). In the current study, one dog was presented with a corneal perforation on the location of a previous deep stromal ulcer 1 month after healing.…”

Section: Discussionmentioning

confidence: 99%

Outcome of medical therapy for keratomalacia in dogs

Guyonnet

Desquilbet

Faure

et al. 2020

J of Small Animal Practice

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Objectives To evaluate the clinical and visual outcomes following intensive medical therapy for keratomalacia in dogs. Materials and Methods Medical records were screened to identify dogs with corneal ulcers and keratomalacia. All patients were given the same topical treatment protocol with frequent administrations of tobramycin in combination with equine serum. Surgical treatment during the first 15 days of follow‐up was considered as medical treatment failure. Results We report on 57 ulcers with keratomalacia from 53 dogs. Medical treatment was successful in 31 of 57 ulcers with a median healing time of 5 days (range 2 to 15 days). At 60 days after epithelialisation, 14/15 medically‐treated eyes were visual. In one case, corneal perforation was observed 1 month after healing and required surgical stabilisation. Clinical Significance Intensive medical therapy has the potential to achieve healing of some ulcers with keratomalacia. Surgical stabilisation in response to progression of stromal loss was required in less than half of the cases.

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Section: Discussionmentioning

confidence: 99%

Outcome of medical therapy for keratomalacia in dogs

Guyonnet

Desquilbet

Faure

et al. 2020

J of Small Animal Practice

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“…Scarring in this location has the potential to cause substantial visual loss, even if the infecting organism is successfully eradicated. 75 Although some bacteria (e.g., Neisseria gonorrhoeae) can invade an intact corneal epithelium, most cases of bacterial keratitis develop at the site of an abnormality or defect in the corneal surface.…”

Section: Natural Historymentioning

confidence: 99%

Bacterial Keratitis Preferred Practice Pattern®

et al. 2019

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“…For a subset of 50 patients from the original SCUT study, visual outcomes at 4 years have been reported. 39 Twenty-four of these patients were in the corticosteroid group and 26 in the placebo arm. Visual acuity improved most during the first 3 weeks of treatment (by 2.9 lines) and then continued to improve slowly over the first year.…”

Section: Topical Corticosteroids: a Controversial Issuementioning

confidence: 99%

Role of steroids in the treatment of bacterial keratitis

Palioura¹,

Henry²,

Amescua³

et al. 2016

OPTH

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Bacterial keratitis can lead to severe visual impairment from corneal ulceration, subsequent scarring, and possible perforation. The mainstay of treatment is topical antibiotics, whereas the use of adjunctive topical corticosteroid drops remains a matter of debate. Herein, we review the rationale for and against the use of topical corticosteroids and we assess their effectiveness and safety in the published randomized controlled trials that have evaluated their role as adjunctive therapy for bacterial corneal ulcers. In the largest study to date, the Steroids for Corneal Ulcers Trial, topical corticosteroid drops were neither helpful nor harmful for the 500 participants as a whole. However, subgroup analyses suggested that topical corticosteroids may be beneficial upon early administration (within 2–3 days after starting antibiotics) for more central corneal ulcers with poorer vision at presentation, for invasive Pseudomonas strains, and for non-Nocardia ulcers. These results are discussed within the limitations of the study.

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Visual Outcomes in Treated Bacterial Keratitis: Four Years of Prospective Follow-up

Cited by 28 publications

References 12 publications

Outcome of medical therapy for keratomalacia in dogs

Outcome of medical therapy for keratomalacia in dogs

Bacterial Keratitis Preferred Practice Pattern®

Role of steroids in the treatment of bacterial keratitis

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