Visual temporal frequency preference shows a distinct cortical architecture using fMRI

Chai, Yuhui; Handwerker, Daniel A.; Marrett, Sean; Gonzalez‐Castillo, Javier; Merriam, Elisha P.; Hall, Andrew W.; Molfese, Peter J.; Bandettini, Peter A.

doi:10.1016/j.neuroimage.2019.04.048

Cited by 21 publications

(28 citation statements)

References 49 publications

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“…This can manifest itself as a velocity tuning of visual gamma oscillations, which would result in the observed bellshaped dependency of GR power on visual motion velocity. Neural selectivity for certain velocities or temporal frequencies of visual motion has furthermore been reported in studies that used other neuroimaging methods and stimulation parameters [35][36][37][38].…”

Section: Introductionmentioning

confidence: 80%

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Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response

et al. 2020

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It is commonly acknowledged that gamma-band oscillations arise from interplay between neural excitation and inhibition; however, the neural mechanisms controlling the power of stimulus-induced gamma responses (GR) in the human brain remain poorly understood. A moderate increase in velocity of drifting gratings results in GR power enhancement, while increasing the velocity beyond some 'transition point' leads to GR power attenuation. We tested two alternative explanations for this nonlinear input-output dependency in the GR power. First, the GR power can be maximal at the preferable velocity/temporal frequency of motion-sensitive V1 neurons. This 'velocity tuning' hypothesis predicts that lowering contrast either will not affect the transition point or shift it to a lower velocity. Second, the GR power attenuation at high velocities of visual motion can be caused by changes in excitation/inhibition balance with increasing excitatory drive. Since contrast and velocity both add to excitatory drive, this 'excitatory drive' hypothesis predicts that the 'transition point' for lowcontrast gratings would be reached at a higher velocity, as compared to high-contrast gratings. To test these alternatives, we recorded magnetoencephalography during presentation of low (50%) and high (100%) contrast gratings drifting at four velocities. We found that lowering contrast led to a highly reliable shift of the GR suppression transition point to higher velocities, thus supporting the excitatory drive hypothesis. No effects of contrast or velocity were found in the alpha-beta range. The results have implications for understanding the mechanisms of gamma oscillations and developing gamma-based biomarkers of disturbed excitation/inhibition balance in brain disorders.

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Section: Introductionmentioning

confidence: 80%

“…There are, however, some observations that are difficult to explain using the 'velocity tuning' hypothesis. Depending on the imaging methods used, the temporal frequencies that induce maximal response may differ [35][36][37][38]. Neural spiking rates furthermore do not necessarily peak at the same temporal frequencies as GR power does.…”

Section: Introductionmentioning

confidence: 99%

Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response

et al. 2020

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“…This study showed that the V1 activity increased with the temporal frequency from 2 to 8 Hz in older adults. Previous studies among younger adults [ 21 – 29 ] also showed the increase in V1 brain response with stimulus temporal frequency up to 8 Hz. According to the present and the previous results, it is expected that the temporal-frequency dependence of V1 activity up to 8 Hz may be similar between younger and older adults.…”

Section: Discussionmentioning

confidence: 73%

“…The passive viewing task might induce sleepiness in participants and might affect V1 BOLD response. A recent study about BOLD response change with temporal frequency of flickering visual stimulus in younger adults used vigilance task during stimulus viewing and excluded participants who did not meet the criteria of vigilance task performance [ 21 ]. Although the task in this study was passive, the experimenter monitored that the eyelids of the participants were open during the task.…”

Section: Discussionmentioning

confidence: 99%

BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults

et al. 2021

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Many older adults have difficulty seeing brief visual stimuli which younger adults can easily recognize. The primary visual cortex (V1) may induce this difficulty. However, in neuroimaging studies, the V1 response change to the increase of temporal frequency of visual stimulus in older adults was unclear. Here we investigated the association between the temporal frequency of flickering stimuli and the BOLD activity within V1 in older adults, using surface-based fMRI analysis. The fMRI data from 29 healthy older participants stimulated by contrast-reversing checkerboard at temporal flicker frequencies of 2, 4, and 8 Hz were obtained. The participants also performed a useful field of view (UFOV) test. The slope coefficient of BOLD activity regarding the temporal frequency of the visual stimulus averaged within V1 regions of interest was positive and significantly different from zero. Group analysis in the V1 showed significant clusters with positive slope and no significant clusters with a negative slope. The correlation coefficient between the slope coefficient and UFOV performance was not significant. The results indicated that V1 BOLD response to a flickering visual stimulus increases as the stimulus temporal frequency increases from 2 to 8 Hz in older adults.

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“…Indeed, although the main differential effect of frequency was located far from the calcarine sulcus, it also involved some mid hemispheric areas presumably included in the spectroscopic voxel. As an illustration, heterogeneity in the response to stimulation within V1 might be due to, e.g., eccentricity (67), which we however minimized by using a 3° foveal stimulation. There is also an hemispherical lateralization for the spatial frequencies (73), but this is not likely to apply to our study, as we used the same radial checkerboard (i.e., including many spatial frequencies) for both PF and UF.…”

Section: Discussionmentioning

confidence: 99%

Perception affects the brain’s metabolic response to sensory stimulation

DiNuzzo

Mangia

Moraschi

et al. 2021

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Processing of incoming sensory stimulation triggers an increase of cerebral perfusion and blood oxygenation (neurovascular response) as well as an alteration of the metabolic neurochemical profile (neurometabolic response). Here we show that perceived and unperceived isoluminant chromatic flickering stimuli designed to have similar neurovascular responses as measured by blood oxygenation level dependent functional MRI (BOLD-fMRI) in primary visual cortex (V1) have markedly different neurometabolic responses as measured by functional MRS. In particular, a significant regional buildup of lactate, an index of aerobic glycolysis, and glutamate, an index of malate-aspartate shuttle, occurred in V1 only when the flickering is perceived, without any relation with behavioral or physiological variables. Wheras the BOLD-fMRI signal in V1, a proxy for input to V1, was insensitive to flickering perception by design, the BOLD-fMRI signal in secondary visual areas was larger during perceived than unperceived flickering indicating increased output from V1. These results indicate that the upregulation of energy metabolism induced by visual stimulation depends on the type of information processing taking place in V1, and that 1H-fMRS provides unique information about local input/output balance that is not measured by BOLD-fMRI.

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Visual temporal frequency preference shows a distinct cortical architecture using fMRI

Cited by 21 publications

References 49 publications

Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response

Additive effect of contrast and velocity suggests the role of strong excitatory drive in suppression of visual gamma response

BOLD signal response in primary visual cortex to flickering checkerboard increases with stimulus temporal frequency in older adults

Perception affects the brain’s metabolic response to sensory stimulation

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