Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction

Wu, Edwin; Judd, Robert M.; Vargas, J; Klocke, Francis J.; Bonow, Robert O.; Kim, Raymond J.

doi:10.1016/s0140-6736(00)03567-4

Cited by 683 publications

(388 citation statements)

References 24 publications

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“…Most patients without myocarditis pattern were likely to have an ischemic injury, as supported by their higher risk for coronary disease, the frequent presence of rest-SPECT defects and of typical DCE pattern of ischemic necrosis (15)(16)(17)(18)40). The lack of relevant coronary angiographic finding in these patients might relate to the systematic antithrombotic therapy prior to coronary angiography or to the possible occlusion of a small coronary branch, inaccessible to visual angiographic examination, as suggested by the limited extent of DCE areas (6 Ϯ 4% of LV).…”

Section: Discussionmentioning

confidence: 97%

“…Each patient was classified according to the distribution pattern of DCE: 1) myocarditis pattern was defined as DCE predominating for at least one segment in the epicardial quartiles of the myocardium for lateral, inferior, apical and anterior LV walls, and on the right side of septal wall (20); 2) ischemic pattern was defined as a single and focal DCE with transmural or subendocardial distribution (18). Differentiation between intramyocardial DCE areas, nearby pericardium, and pericardial fat was assessed using side-by-side analysis of the IR-GRE static images and the corresponding movie slices acquired with SSFP sequence before and after gadolinium-DTPA injection (Figs.…”

Section: Cardiac Mrimentioning

confidence: 99%

“…DCE identifies acute or chronic myocardial infarction even when restricted to small subendocardial areas (17,18). MRI with hyperenhancement gadolinium-tracer analysis has also been successfully applied in identifying myocarditis, either by using a nonbreathhold T1-weighted spin-echo pulse sequence (19), or the newer inversion-recovery gradient-echo pulse (IR-GRE) sequences dedicated to DCE analysis (20,21).…”

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confidence: 99%

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Detection of myocarditis by contrast‐enhanced MRI in patients presenting with acute coronary syndrome but no coronary stenosis

Codreanu

Djaballah

Angioı̈

et al. 2007

Magnetic Resonance Imaging

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Purpose:To prospectively assess the use of cardiac MRI with delayed contrast enhancement (DCE) for identifying patients with active myocarditis among those presenting with acute coronary syndrome (ACS) but no coronary stenosis. Materials and Methods:A total of 27 consecutive patients (age ϭ 45 Ϯ 17 years; 14 male) presenting with ACS (chest pain, positive troponin-I) and no coronary stenosis, underwent cardiac MRI 9 Ϯ 7 days after pain onset and 8 Ϯ 5 months later (N ϭ 19). Steady-state free-precession pulse (SSFP) sequence was applied for the assessment of myocardial function and both inversion-recovery (IR) and SSFP sequences were used for analyzing the topography and extent of DCE areas. Rest sestamibi-gated-single photon emission CT (SPECT) was also systematically performed.Results: Subepicardial DCE pattern typical of acute myocarditis was documented in 12 patients (44%). Ischemic DCE pattern (transmural or subendocardial focal DCE) was documented in 12 of the 15 remaining patients (44%). Patients with subepicardial DCE had: higher C-reactive protein (CRP) levels (38 Ϯ 32 vs. 14 Ϯ 24 mg/mL; P ϭ 0.04), lower Framingham cardiovascular risk (3 Ϯ 3% vs. 9 Ϯ 5%; P Ͻ 0.001), lower incidence of perfusion SPECT defects (17% vs. 73%; P ϭ 0.01), higher left ventricular (LV) enddiastolic volume (77 Ϯ 16 vs. 64 Ϯ 10 mL/m 2 ; P ϭ 0.02), and higher regression of DCE areas at follow-up (-65 Ϯ 17% vs. -18 Ϯ 23%; P ϭ 0.002).Conclusion: DCE pattern of active myocarditis can be seen in patients presenting with ACS but no coronary stenosis.

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Section: Discussionmentioning

confidence: 97%

Section: Cardiac Mrimentioning

confidence: 99%

mentioning

confidence: 99%

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Detection of myocarditis by contrast‐enhanced MRI in patients presenting with acute coronary syndrome but no coronary stenosis

Codreanu

Djaballah

Angioı̈

et al. 2007

Magnetic Resonance Imaging

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“…DELAYED CONTRAST-ENHANCED VIABILITY magnetic resonance imaging (MRI) of the myocardium is a valuable tool for the detection of myocardial infarction (MI), various types of cardiomyopathies, and postinterventional findings (1)(2)(3)(4)(5)(6)(7)(8). Because of its high spatial resolution and image contrast, viability MRI visualizes the subendocardial MI and myocardial damage associated with hypertrophic cardiomyopathy (HCM) and sarcoidosis that cannot be detected with other imaging modalities (5)(6)(7).…”

mentioning

confidence: 99%

“…Because of its high spatial resolution and image contrast, viability MRI visualizes the subendocardial MI and myocardial damage associated with hypertrophic cardiomyopathy (HCM) and sarcoidosis that cannot be detected with other imaging modalities (5)(6)(7). The transmural extension of MI and myocardial fibrosis in HCM assessed using delayed contrast-enhanced viability imaging are strongly related to regional and global cardiac function, remodeling, and indications for revascularization (1,4,6).…”

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confidence: 99%

Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

Amano

Matsumura

Kumita

2008

Magnetic Resonance Imaging

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Purpose:To assess the feasibility of free-breathing highspatial-resolution delayed contrast-enhanced three-dimensional (3D) viability magnetic resonance imaging (MRI) at 3.0T for the detection of myocardial damages. Materials and Methods:Twenty-five patients with myocardial diseases, including myocardial infarction and cardiomyopathies, were enrolled after informed consent was given. Free-breathing 3D viability MRI with high spatial resolution (1.5 ϫ 1.25 ϫ 2.5 mm) at 3.0T, for which cardiac and navigator gating techniques were employed, was compared with breath-hold two-dimensional (2D) viability imaging (1.77 ϫ 1.18 ϫ 10 mm) for assessment of contrastto-noise ratio (CNR) and myocardial damage.Results: Free-breathing 3D viability imaging was achieved successfully in 21 of the 25 patients. This imaging technique depicted 84.6% of hyperenhancing myocardium with a higher CNR between hyperenhancing myocardium and blood and with excellent agreement for the transmural extension of myocardial damage (k ϭ 0.91). In particular, the 3D viability images delineated the myocardial infarction and linear hyperenhancing myocardium, comparable to the 2D viability images. Conclusion:Free-breathing high-spatial-resolution delayed contrast-enhanced 3D viability MRI using 3.0T was feasible for the evaluation of hyperenhancing myocardium, as seen with myocardial infarction and cardiomyopathies.

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Prevalence and Prognosis of Unrecognized Myocardial Infarction Determined by Cardiac Magnetic Resonance in Older Adults

Schelbert¹,

Cao²,

Sigurðsson³

et al. 2012

JAMA

253

219

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HE PREVALENCE AND PROGNOsis of unrecognized myocardial infarction (MI) in older people with and without diabetes may be higher than previously suspected in population studies. [1][2][3][4] Advances in MI detection, such as cardiac magnetic resonance (CMR) imaging with late gadolinium enhancement (LGE), are more sensitive than prior methods. 5 Ascertaining the prevalence of unrecognized MI (UMI) in these groups is relevant because age and diabetes increase the risks of coronary heart disease. 6 Pathologic studies 7 indicate that subclinical coronary plaque rupture occurs frequently, particularly in diabetic individuals, which may culminate in a high prevalence of UMI.Several population studies 1-4 have described the prevalence of UMI based on electrocardiography (ECG), but ECG Author Affiliations are listed at the end of this article.

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Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction

Cited by 683 publications

References 24 publications

Detection of myocarditis by contrast‐enhanced MRI in patients presenting with acute coronary syndrome but no coronary stenosis

Detection of myocarditis by contrast‐enhanced MRI in patients presenting with acute coronary syndrome but no coronary stenosis

Free‐breathing high‐spatial‐resolution delayed contrast‐enhanced three‐dimensional viability MR imaging of the myocardium at 3.0T: A feasibility study

Prevalence and Prognosis of Unrecognized Myocardial Infarction Determined by Cardiac Magnetic Resonance in Older Adults

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