2023
DOI: 10.3390/pharmaceutics15061657
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Visualization and Estimation of Nasal Spray Delivery to Olfactory Mucosa in an Image-Based Transparent Nasal Model

Abstract: Background: Nose-to-brain (N2B) drug delivery offers unique advantages over intravenous methods; however, the delivery efficiency to the olfactory region using conventional nasal devices and protocols is low. This study proposes a new strategy to effectively deliver high doses to the olfactory region while minimizing dose variability and drug losses in other regions of the nasal cavity. Materials and Methods: The effects of delivery variables on the dosimetry of nasal sprays were systematically evaluated in a … Show more

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Cited by 10 publications
(5 citation statements)
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“…These anatomical distinctions pose difficulties in accurately determining effective intranasal drug dosing for human application, especially with experimental therapeutics like FBP9R/siRNA. However, recent technical advancements such as mucosal flap reconstruction and pressurized olfactory devices show promise in enhancing drug deposition beyond the nasal valve [ 69 , 70 ]. Continued exploration of such techniques may enhance the precision and clinical success of intranasal delivery for brain-associated disorders.…”
Section: Discussionmentioning
confidence: 99%
“…These anatomical distinctions pose difficulties in accurately determining effective intranasal drug dosing for human application, especially with experimental therapeutics like FBP9R/siRNA. However, recent technical advancements such as mucosal flap reconstruction and pressurized olfactory devices show promise in enhancing drug deposition beyond the nasal valve [ 69 , 70 ]. Continued exploration of such techniques may enhance the precision and clinical success of intranasal delivery for brain-associated disorders.…”
Section: Discussionmentioning
confidence: 99%
“…The nasal model N0, representing a normal condition, was previously developed from MRI scans of a 53-year-old male with no reported respiratory diseases [ 43 , 44 ]. The remaining three models (N1, P1, and P2) were modified from model N0, with changes made to the left inferior turbinate to reflect various degrees of congestion and decongestion.…”
Section: Methodsmentioning
confidence: 99%
“…The nasal models, M1 and M2 (Figure 1), were developed from MRI scans of a 53-yearold male [14,24]. Both models were created based on the left nasal passage, including the nasal septum, to allow for clear visualization of spray delivery, liquid film mobilization, and final deposition distribution within the turbulent region during the experimental runs.…”
Section: Nasal Cavity Modelsmentioning
confidence: 99%
“…The effectiveness of nasal spray pumps in targeting specific areas within the nasal cavity is critically dependent on the intricacies of nasal cavity anatomy and functionality. These regions offer unique advantages for both targeted and systemic drug administration, which are influenced by factors including the drug formulation, the nasal spray pump design, the application method, and the deposition site, alongside the patient's nasal health [12][13][14][15]. However, conventional nasal sprays often fail to deliver drugs effectively to the posterior turbinate region and nasopharynx due to the geometrical complexity of the nasal cavity.…”
Section: Introductionmentioning
confidence: 99%
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