Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer

Wang, Zhiyi; Li, Ziyuan; Sun, Zhaoli; Wang, Shuren; Ali, Zeeshan; Zhu, Shu; Sha, Liu; Ren, Qiushi; Sheng, Fugeng; Wang, Baodui; Hou, Yanglong

doi:10.1126/sciadv.abc8733

Cited by 121 publications

(99 citation statements)

References 41 publications

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“…However, this issue can be overcome by protecting the magnetic Fe core inside an inert thin Au shell, while simultaneously the properties of both constituents are preserved [32]. Moreover, among different bimetallic nanostructures, core-shell (CS) configurations are an important class where different functions are integrated into one particle in a controlled fashion along with optimized morphologies and compositions [33,34]. Many different strategies have been reported for the synthesis of CS Fe-Au NPs with simultaneous evaluation of composition and size-dependent properties or structures [35][36][37].…”

Section: Introductionmentioning

confidence: 99%

Multidimensional thermally-induced transformation of nest-structured complex Au-Fe nanoalloys towards equilibrium

et al. 2021

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Bimetallic nanoparticles are often superior candidates for a wide range of technological and biomedical applications owing to their enhanced catalytic, optical, and magnetic properties, which are often better than their monometallic counterparts. Most of their properties strongly depend on their chemical composition, crystallographic structure, and phase distribution. However, little is known of how their crystal structure, on the nanoscale, transforms over time at elevated temperatures, even though this knowledge is highly relevant in case nanoparticles are used in, e.g., high-temperature catalysis. Au-Fe is a promising bimetallic system where the low-cost and magnetic Fe is combined with catalytically active and plasmonic Au. Here, we report on the in situ temporal evolution of the crystalline ordering in Au-Fe nanoparticles, obtained from a modern laser ablation in liquids synthesis. Our in-depth analysis, complemented by dedicated atomistic simulations, includes a detailed structural characterization by X-ray diffraction and transmission electron microscopy as well as atom probe tomography to reveal elemental distributions down to a single atom resolution. We show that the Au-Fe nanoparticles initially exhibit highly complex internal nested nanostructures with a wide range of compositions, phase distributions, and size-depended microstrains. The elevated temperature induces a diffusion-controlled recrystallization and phase merging, resulting in the formation of a single face-centered-cubic ultrastructure in contact with a body-centered cubic phase, which demonstrates the metastability of these structures. Uncovering these unique nanostructures with nested features could be highly attractive from a fundamental viewpoint as they could give further insights into the nanoparticle formation mechanism under non-equilibrium conditions. Furthermore, the in situ evaluation of the crystal structure changes upon heating is potentially relevant for high-temperature process utilization of bimetallic nanoparticles, e.g., during catalysis.

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Section: Introductionmentioning

confidence: 99%

Multidimensional thermally-induced transformation of nest-structured complex Au-Fe nanoalloys towards equilibrium

et al. 2021

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“…To overcome the biological barriers of drug delivery, in one study, a precise tumor-targeting nanozyme (Ag 2 S@Fe 2 C-DSPE-PEG-iRGD) was rationally prepared for enhanced cancer therapy [ 240 ]. This nanozyme displayed efficient intracellular uptake, intense fluorescence, and high level of ROS production in cancer cells.…”

Section: Diagnosis and Monitoring Of Cancer Therapymentioning

confidence: 99%

Chemodynamic nanomaterials for cancer theranostics

et al. 2021

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It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic efficacy. Fenton- and Fenton-like reaction-based chemodynamic therapy (CDT) are new strategies to enhance anticancer efficacy due to their capacity to generate reactive oxygen species (ROS) and oxygen (O2). On the one hand, the generated ROS can damage the cancer cells directly. On the other hand, the generated O2 can relieve the hypoxic condition in the tumor microenvironment (TME) which hinders efficient photodynamic therapy, radiotherapy, etc. Therefore, CDT can be used together with many other therapeutic strategies for synergistically enhanced combination therapy. The antitumor applications of Fenton- and Fenton-like reaction-based nanomaterials will be discussed in this review, including: (iþ) producing abundant ROS in-situ to kill cancer cells directly, (ii) enhancing therapeutic efficiency indirectly by Fenton reaction-mediated combination therapy, (iii) diagnosis and monitoring of cancer therapy. These strategies exhibit the potential of CDT-based nanomaterials for efficient cancer therapy.

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“…[15] . 北京大学侯仰龙教授构建了肿瘤穿膜肽包裹的 Ag2S@Fe2C 纳米酶系统，利用其光热治疗(PTT)和增强的 CDT 实现了对乳腺癌的强化联合治疗 [16] . 中科院长春应化所林君研究员/哈尔滨工程大学杨飘萍教授以及北京化工大学刘惠玉教授等分别报道了具有双重酶催化活性的纳米酶，不仅提高氧化应激和缓解乏氧，而且利用光热效应协同改善了纳米酶的催化活性 [17,18] .…”

Section: 作为一类具有类酶催化活性的纳米结构材料，纳米酶可以催化肿瘤微环境中的内源性物质提供unclassified

Manganese-doped gold nanoclusters with ultrasmall size andmicroenvironment-responsive visualized theranostics of tumor

Sun¹,

Wu²,

Zhang³

et al. 2021

Sci. Sin.-Chim

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Inorganic nanoprobes with ultrasmall size have the advantage of kidney clearance, which was very meaningful for achieving clinical application. In this paper, Mn 2+ -doped gold nanoclusters (Mn-AuNCs) with ultrasmall size were synthesized, by which magnetic resonance imaging (MRI) and tumor-microenvironmentresponsive chemodynamic therapy (CDT) and photodynamic therapy (PDT) were achieved. The results showed that Mn-AuNCs nanoprobe occupied ultrasmall size of about 2-3 nm, and excellent T1-weighted MRI performance with a high longitudinal relaxivity of 31.71 mM -1 •s -1 . In tumor microenvironment, Mn-AuNCs nanoprobes can catalyze H2O2 to produce •OH, O2 and singlet oxygen, showing CDT and enhanced PDT performances. Under the irradiation of 635 nm laser, the viability of 4T1 cells incubated with Mn-AuNCs was decreased to be 10%, and tumors were disappeared completely, achieving MRI-guided CDT/PDT combination therapy.

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Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer

Cited by 121 publications

References 41 publications

Multidimensional thermally-induced transformation of nest-structured complex Au-Fe nanoalloys towards equilibrium

Multidimensional thermally-induced transformation of nest-structured complex Au-Fe nanoalloys towards equilibrium

Chemodynamic nanomaterials for cancer theranostics

Manganese-doped gold nanoclusters with ultrasmall size andmicroenvironment-responsive visualized theranostics of tumor

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