Visualization of Auditory Habituation by fMRI

Pfleiderer, Bettina; Ostermann, Jens; Michael, N.; Heindel, Walter

doi:10.1006/nimg.2002.1308

Cited by 31 publications

(26 citation statements)

References 40 publications

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“…The current data obtained at 3 T confirm our previous results (6). Moreover, habituation appears to be independent of field.…”

Section: Discussionsupporting

confidence: 91%

“…In the present study we focused on the primary auditory cortex and chose a pure sine tone as a simple acoustic, and a neutral (non-speech) stimulus, because this basic paradigm has been shown to be reproducible and robust. In our previous work at 1.5 T a characteristic signal decay with repeated two-minute acoustic stimulation in healthy subjects was observed (6). The aim of the present study was to determine whether measured habituation is field-dependent, and whether results obtained at 1.5 T could still be used as a reference at higher field.…”

Section: Discussionmentioning

confidence: 76%

“…Habituation, which can be defined as the reduction of activation after prolonged or repeated exposure to stimuli, is an adaptive ability to cease response to repetitive events in an environment (6 -8). Previous studies revealed a characteristic signal decay following repeated acoustic stimulation in the primary and secondary auditory cortexes (6). Severely depressed patients presented a different pattern, with significantly lower activation after the first stimulation block (P ϭ 0.05), no characteristic signal decay with repeated acoustic stimulation, and a marked undershoot after each stimulation block (7).…”

mentioning

confidence: 92%

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fMRI studies of sensitivity and habituation effects within the auditory cortex at 1.5 T and 3 T

Rabe

Michael

Kugel

et al. 2006

Magnetic Resonance Imaging

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Purpose: To assess habituation effects in relation to field strength by fMRI at 1.5 vs. 3.0 T within the auditory cortex of healthy subjects. Materials and Methods:fMRI experiments were performed on 19 healthy subjects at 1.5 T (N ϭ 12) and 3 T (N ϭ 12). The auditory cortex was stimulated binaurally by digitally generated pulsed ( ϭ 5 Hz) 800 Hz sine tones with three alternating on and off periods. Results:The mean activation after stimulation (4.4% Ϯ 1.2% (1.5 T) and 5.3% Ϯ 2.3% (3 T)) and number of activated pixels (96.7 Ϯ 49.8 (1.5 T) and 139.9 Ϯ 101 (3 T)) were higher at 3 T compared to 1.5 T; however, that difference did not reach statistical significance. A characteristic signal decay with repeated stimuli was revealed at both 1.5 and 3 T, and the response to the second and third stimulation blocks was significantly lower compared to the first. The habituation pattern was the same, independently of field strength and age. Conclusion:The mean activation and number of pixels were only modestly higher at 3 T, probably due to higher physiologic noise and higher local macroscopic susceptibility gradients within the temporal lobes at 3 T. Our data reveal that measured auditory habituation is independent of field strength, and data obtained at two different field strengths do not differ fundamentally in this context.

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“…The current data obtained at 3 T confirm our previous results (6). Moreover, habituation appears to be independent of field.…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 92%

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fMRI studies of sensitivity and habituation effects within the auditory cortex at 1.5 T and 3 T

Rabe

Michael

Kugel

et al. 2006

Magnetic Resonance Imaging

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“…Previous studies have circumvented this limitation with summary time series, such as mean BOLD or mean reaction time by block [Toni et al, 2002] or condition [Tracy et al, 2003]. The present framework of analysis is expected to be useful in the investigation of other slowly varying neurophysiological processes such as learning [Floyer-Lea et al, 2005], habituation [Pfleiderer et al, 2002], chronic pain [Borsook et al, 2006], and therapeutic effects [Schweinhardt et al, 2006].…”

Section: Discussionmentioning

confidence: 98%

Multivariate Granger causality analysis of fMRI data

Deshpande

LaConte

James

et al. 2008

Human Brain Mapping

217

214

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This article describes the combination of multivariate Ganger causality analysis, temporal down-sampling of fMRI time series, and graph theoretic concepts for investigating causal brain networks and their dynamics. As a demonstration, this approach was applied to analyze epoch-to-epoch changes in a hand-gripping, muscle fatigue experiment. Causal influences between the activated regions were analyzed by applying the directed transfer function (DTF) analysis of multivariate Granger causality with the integrated epoch response as the input, allowing us to account for the effects of several relevant regions simultaneously. Integrated responses were used in lieu of originally sampled time points to remove the effect of the spatially varying hemodynamic response as a confounding factor; using integrated responses did not affect our ability to capture its slowly varying affects of fatigue. We separately modeled the early, middle, and late periods in the fatigue. We adopted graph theoretic concepts of clustering and eccentricity to facilitate the interpretation of the resultant complex networks. Our results reveal the temporal evolution of the network and demonstrate that motor fatigue leads to a disconnection in the related neural network.

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“…Voxel position was assigned according to Creutzfeldt (1983) to include Brodmann area 24/32 (Economo L A /FDL) as described previously (Pfleiderer et al, 2002; see Figure 1). To assure high intraindividual reproducibility, scans were referenced to readily identifiable anatomic landmarks within the brain; the base of the voxel was aligned perpendicular to the tip of the genu corporis callosi (Pfleiderer et al, 2003).…”

Section: Magnetic Resonance Spectroscopy ( 1 H-mrs)mentioning

confidence: 99%

Acute Shift in Glutamate Concentrations Following Experimentally Induced Panic with Cholecystokinin Tetrapeptide—A 3T-MRS Study in Healthy Subjects

Zwanzger

Zavorotnyy

Gencheva

et al. 2013

Neuropsychopharmacol

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According to preclinical studies, glutamate has been implicated in the pathogenesis of anxiety. In order to elucidate the role of glutamate in anxiety and panic in humans, brain glutamate þ glutamine (Glx) levels were measured during cholecystokinin-tetrapeptide (CCK-4)-induced panic using magnetic resonance spectroscopy (MRS). Eighteen healthy subjects underwent a CCK-4 challenge. MR spectra were obtained from the anterior cingulate cortex (ACC) using a single voxel point-resolved spectroscopy method and analyzed using LCModel. A combined fitting of Glx was performed. Panic was assessed using the Acute Panic Inventory (API) and Panic Symptom Scale (PSS) scores. Moreover, hypothalamic-pituitary-adrenal axis stimulation was monitored throughout the challenge. There was a significant panic response following CCK-4 as revealed by a marked increase in both the panic scores (API: F(1,17) ¼ 149.41; po0.0001; PSS: F(1,17) ¼ 88.03; po0.0001) and heart rate (HR: F(1,17) ¼ 72.79; po0.0001). MRS measures showed a significant increase of brain Glx/creatine (Glx/Cr) levels peaking at 2-10 min after challenge (F(1,17) ¼ 15.94; p ¼ 0.001). There was also a significant increase in CCK-4-related cortisol release (F(6,11) ¼ 8.68; p ¼ 0.002). Finally, significant positive correlations were found between baseline Glx/Cr and both API max (r ¼ 0.598; p ¼ 0.009) and maximum heart rate (HR max ) during challenge (r ¼ 0.519; p ¼ 0.027). Our results suggest that CCK-4-induced panic is accompanied by a significant glutamate increase in the bilateral ACC. The results add to the hypothesis of a disturbance of the inhibitory-excitatory equilibrium and suggest that apart from static alterations rapid and dynamic neurochemical changes might also be relevant for the neural control of panic attacks.

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Visualization of Auditory Habituation by fMRI

Cited by 31 publications

References 40 publications

fMRI studies of sensitivity and habituation effects within the auditory cortex at 1.5 T and 3 T

fMRI studies of sensitivity and habituation effects within the auditory cortex at 1.5 T and 3 T

Multivariate Granger causality analysis of fMRI data

Acute Shift in Glutamate Concentrations Following Experimentally Induced Panic with Cholecystokinin Tetrapeptide—A 3T-MRS Study in Healthy Subjects

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