To improve the strain homogeneity and damage homogeneity of radial forging hollow shaft. Proposed radial forging die with a cycloid as a generatrix entrance surface. The effects of the structural parameters of the die forging surface, such as the radius of cycloid base circle (R), the length of sizing zone (L) and the radius of sizing zone (r) on the strain homogeneity and damage homogeneity of the machined shaft were investigated. Numerical simulations were performed according to the orthogonal design L25, and an artificial neural network approach was used to develop a mathematical prediction model and apply it to the optimization process of the genetic algorithm. The results show that the optimized structural parameters of the compromise solution are R = 68.27mm, L = 49.36mm, r = 11.01mm, εσ and Cσ are 0.2113 and 0.02562, respectively. Compared with the original structural scheme, εσ is reduced by 21.83% and Cσ is reduced by 31.58%, which indicates that the plastic deformation is more uniform and the machining damage is less during the hollow shaft forging process.