Visualization of axonal and volume currents in median nerve compound action potential using magnetoneurography

Nakayama, Kentaro; Kohara, Nobuo; Paku, Masaaki; Sato, Shinji; Nakamura, Masataka; Ando, Muneharu; Taniguchi, Shinichirou; Imamura, Masayuki; Tani, Yoichi; Itakura, Takeshi; Saito, Takanori; YusukeYakushiji, None

doi:10.1016/j.clinph.2023.05.006

Cited by 3 publications

(1 citation statement)

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“…Magnetoneurography is also applicable for the functional imaging of peripheral nerves. Induced magnetic fields measurements and current reconstructions have been reported for the carpal tunnel ( 37 , 38 ), elbow ( 39 ), upper arm ( 40 ), and brachial plexus ( 41 , 42 ), based on peripheral nerve stimulation at the digital nerves, median and/or ulnar nerves at the wrist or elbow. In each case, the reconstructed current waveforms obtained from the measured magnetic field data were compared with the results of conventional surface potential measurements.…”

Section: Applications Of Magnetoneurographymentioning

confidence: 99%

SQUID magnetoneurography: an old-fashioned yet new tool for noninvasive functional imaging of spinal cords and peripheral nerves

Adachi,

Kawabata

2024

Front. Med. Technol.

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We are engaged in the development and clinical application of a neural magnetic field measurement system that utilizes biomagnetic measurements to observe the activity of the spinal cord and peripheral nerves. Unlike conventional surface potential measurements, biomagnetic measurements are not affected by the conductivity distribution within the body, making them less influenced by the anatomical structure of body tissues. Consequently, functional testing using biomagnetic measurements can achieve higher spatial resolution compared to surface potential measurements. The neural magnetic field measurement, referred to as magnetoneurography, takes advantage of these benefits to enable functional testing of the spinal cord and peripheral nerves, while maintaining high spatial resolution and noninvasiveness. Our magnetoneurograph system is based on superconducting quantum interference devices (SQUIDs) similar to the conventional biomagnetic measurement systems. Various design considerations have been incorporated into the SQUID sensor array structure and signal processing software to make it suitable for detecting neural signal propagation along spinal cord and peripheral nerve. The technical validation of this system began in 1999 with a 3-channel SQUID system. Over the course of more than 20 years, we have continued technological development through medical-engineering collaboration, and in the latest prototype released in 2020, neural function imaging of the spinal cord and peripheral nerves, which could also be applied for the diagnosis of neurological disorders, has become possible. This paper provides an overview of the technical aspects of the magnetoneurograph system, covering the measurement hardware and software perspectives for providing diagnostic information, and its applications. Additionally, we discuss the integration with a helium recondensing system, which is a key factor in reducing running costs and achieving practicality in hospitals.

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