Visualization of Blood Flow in AAA Patient-Specific Geometry: 3-D Reconstruction and Simulation Procedures

Algabri, Yousif A.; Altwijri, Omar; Chatpun, Surapong

doi:10.1007/s12668-019-00662-8

Cited by 9 publications

(5 citation statements)

References 51 publications

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“…10: 230563 conservative model of the DF. This study was limited to a few patients like in previous studies [10,20,[25][26][27]32,[38][39][40]. Expansion to additional patients with different geometries in a follow-up study will allow us to present broader conclusions with clinical significance.…”

Section: Discussionmentioning

confidence: 99%

“…Since a more realistic and accurate transient model with FSI will provide lower predictions of the DF, our current model can be seen as a conservative model of the DF. This study was limited to a few patients like in previous studies [ 10 , 20 , 25 – 27 , 32 , 38 – 40 ]. Expansion to additional patients with different geometries in a follow-up study will allow us to present broader conclusions with clinical significance.…”

Section: Discussionmentioning

confidence: 99%

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The effect of stent graft curvature on the hemodynamic displacement force after abdominal aortic aneurysm endovascular repair

Brand,

Yoel,

Eichler

et al. 2023

R. Soc. open sci.

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Endovascular aortic aneurysm repair is a minimally invasive procedure with low mortality and morbidity. Clinical studies have revealed that a displacement force (DF) can cause stent graft (SG) migration in some circumstances requiring repeated intervention. This study aims to determine the relationship between the SG curvature and the calculated DF from four patient-specific computational fluid dynamics models. The SG's curvature was defined according to the centrelines of the implanted SG's branches. The centrelines were defined as either intersecting or separated lines. The centreline curvature (CLC) metrics were calculated based on the local curvature radii and the distances from the centrelines of idealized straight branches. The average CLC value and average variation were calculated to represent the entire graft's curvature. These CLC calculations were compared, and the method that gave the best correlation to the calculated DF was found. The optimal correlation is obtained from calculating the CLC average variation using separated centrelines and distance from straight lines, with an R 2 = 0.89. Understanding the relationship between vascular morphology and DF can help identify at-risk patients before the procedure. In these cases, we can provide appropriate treatment and follow up with the patient to prevent future failure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effect of stent graft curvature on the hemodynamic displacement force after abdominal aortic aneurysm endovascular repair

Brand,

Yoel,

Eichler

et al. 2023

R. Soc. open sci.

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“…Three different mesh densities were evaluated to confirm mesh independence. The refinement of mesh elements is illustrated in Figure 2; the tetrahedral four-node elements are finer near the aortic wall [31].…”

Section: Mesh Generationmentioning

confidence: 99%

Computational Study of Abdominal Aortic Aneurysms with Severely Angulated Neck Based on Transient Hemodynamics Using an Idealized Model

et al. 2022

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An abdominal aortic aneurysm (AAA) is an enlargement of the abdominal aorta that can become a life-threatening disease. The pulsatile blood flow exhibits intricate laminar patterns in the abdominal portion of the human aorta under normal resting conditions, whereas secondary flows are caused by adjacent branches and abnormal vessel geometries. If a pathological disorder (e.g., aneurysm) alters the structural composition of the artery wall, the flow dynamics become more complex. In this study, we analyzed the hemodynamics of pulsatile blood flow in three-dimensional AAA models. Computational predictions of hemodynamic changes were performed considering idealized models for four severe proximal neck angulations of symmetric aneurysms assuming conditions of laminar flow and a rigid artery wall. The predictions were based on computational fluid dynamics throughout the cardiac cycle. Postprocessing was used to visualize the numerical findings. The hemodynamic changes in factors such as velocity, flow streamline, pressure, and wall shear stress were obtained and visualized. The resulting blood flow through the severely angulated proximal neck of the abdominal aorta caused strong turbulence and asymmetric flow inside the aneurysm sac, leading to blood recirculation, especially during diastole. The simulation results showed the formation of regions with high and low wall shear stress, turbulent flow, and recirculation in the aneurysm sac depending on the angulation, which could have led to aortic wall weakness.

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“…[22] Computational fluid dynamics (CFD) simulations help in the analysis of blood flow under certain idealized scenarios and have been widely recognized as an effective tool. [23][24][25][26][27] However, computational results must be validated with experimental data. [16] Laser particle image velocimetry (Laser-PIV) has previously relied on the optical characterization of the velocity field of a fluid using tracer particles and blood-mimicking fluids (BMF's) inside average-anatomy and crude (not patient-specific) models of aneurysmal tissue.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Soft Transparent Patient‐Specific Vascular Models with Stereolithographic 3D printing and Thiol‐Based Photopolymerizable Coatings

Hosseinzadeh,

Bosques‐Palomo,

Carmona‐Arriaga

et al. 2024

Macromol. Rapid Commun.

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An ideal vascular phantom should be anatomically accurate, have mechanical properties as close as possible to the tissue, and be sufficiently transparent for ease of visualization. However, materials that enable the convergence of these characteristics have remained elusive. We report the fabrication of patient‐specific vascular phantoms with high anatomical fidelity and optical transparency, and mechanical properties close to those of vascular tissue. These final properties were achieved by 3D‐printing patient‐specific vascular models with commercial elastomeric acrylic‐based resins before coating with thiol‐based photopolymerizable resins. Ternary thiol‐ene‐acrylate chemistry was found optimal. A PETMP/allyl glycerol ether (AGE)/polyethylene glycol diacrylate (PEGDA) coating with a 30/70% AGE/PEGDA ratio applied on a flexible resin yielded elastic modulus, UTS and elongation of 3.41 MPa, 1.76 MPa and 63.2%, respectively, in range with the human aortic wall. The PETMP/AGE/PEGDA coating doubled the optical transmission from 40% to 80%, approaching the 88% of the benchmark silicone‐based elastomer. Higher transparency correlates with a decrease in surface roughness from 2000 to 90 nm after coating. Coated 3D‐printed anatomical replicas are showcased for pre‐procedural planning and medical training with good radio‐opacity and echogenicity. Thiol‐click chemistry coatings, as a surface treatment for elastomeric stereolithographic 3D‐printed objects, address inherent limitations of photopolymer‐based additive manufacturing.This article is protected by copyright. All rights reserved

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Visualization of Blood Flow in AAA Patient-Specific Geometry: 3-D Reconstruction and Simulation Procedures

Cited by 9 publications

References 51 publications

The effect of stent graft curvature on the hemodynamic displacement force after abdominal aortic aneurysm endovascular repair

The effect of stent graft curvature on the hemodynamic displacement force after abdominal aortic aneurysm endovascular repair

Computational Study of Abdominal Aortic Aneurysms with Severely Angulated Neck Based on Transient Hemodynamics Using an Idealized Model

Fabrication of Soft Transparent Patient‐Specific Vascular Models with Stereolithographic 3D printing and Thiol‐Based Photopolymerizable Coatings

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