Visualization of Focal Thinning of the Ganglion Cell–Inner Plexiform Layer in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

Shao, Yi; Jiang, Hong; Wei, Yantao; Shi, Yingying; Shi, Chaoji; Wright, Clinton B.; Sun, Xiaoyan; Vanner, Elizabeth A.; Rodriguez, Anny; Lam, Byron L.; Rundek, Tatjana; Baumel, Bernard; Gameiro, Giovana Rosa; Dong, Chuanhui; Wang, Jianhua

doi:10.3233/jad-180070

Cited by 50 publications

(85 citation statements)

References 33 publications

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“…The focal thickness reduction zone in the intraretinal layers generally represents the area that is most seriously affected by certain diseases (Table 2). 15,16,[26][27][28][29][30][31][32][33] Different thickness reduction patterns were documented in different systemic conditions, such as Alzheimer's disease, 16 and ocular disorders, such as glaucoma. [26][27][28] These characteristic patterns often provide disease-specific information and better discrimination powers compared with averaged thickness.…”

Section: Discussionmentioning

confidence: 99%

“…As described previously, 16,17,20 the custom UHR-OCT system is a spectral domain OCT with an axial resolution of~3 lm in tissue and a scan speed of 24,000 A-scans per second. The scan pattern was a raster scan with 512 A-scans (per B-scan) 3 128 B-scans, which covered a field of view of 6 3 6 mm centered on the fovea.…”

Section: Topographic Thickness Maps Of Intraretinal Layers Using Ultrmentioning

confidence: 99%

“…subtracting the thickness maps of control eyes from the thicknesses of the MSON or MSFE eyes to create thickness alteration maps. 16 Visualization was rendered using MATLAB software (version 2014b, MathWorks, Natick, MA, USA).…”

Section: Topographic Thickness Maps Of Intraretinal Layers Using Ultrmentioning

confidence: 99%

“…However, it is hard to exclude subclinical ON clinically, which occurs with high incidence in patients with MS. [3][4][5] The averaged thicknesses of the GCIPL and pRNFL that are used in intereye approaches 11,13,14 may not be sensitive enough to identify optic nerve damage. Because the distribution of the neural fiber and ganglion cells are not even, [15][16][17] and the alterations in these neural layers are not even. 15,16 The average thicknesses of these layers using arbitrary partitions, such as the elliptical partition, which is commonly used in the clinic, may not well define the focal thickness alterations 11,13,14 and could render the moderate discrimination power when using the intereye thickness difference approach.…”

mentioning

confidence: 99%

“…Because the distribution of the neural fiber and ganglion cells are not even, [15][16][17] and the alterations in these neural layers are not even. 15,16 The average thicknesses of these layers using arbitrary partitions, such as the elliptical partition, which is commonly used in the clinic, may not well define the focal thickness alterations 11,13,14 and could render the moderate discrimination power when using the intereye thickness difference approach.…”

mentioning

confidence: 99%

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Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

Jiang

Gameiro

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionmentioning

confidence: 99%

Section: Topographic Thickness Maps Of Intraretinal Layers Using Ultrmentioning

confidence: 99%

Section: Topographic Thickness Maps Of Intraretinal Layers Using Ultrmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

Jiang

Gameiro

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults

et al. 2022

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IMPORTANCEAlthough there is abundant evidence relating neuronal and vascular optical coherence tomography (OCT) and OCT angiography (OCTA) measures to retinal disease, data on the normative distribution of retinal features and their associations with visual function in a healthy, older, community-based population are sparse.OBJECTIVES To characterize the normative OCT and OCTA measures in older adults and describe their associations with visual function. DESIGN, SETTING, AND PARTICIPANTSThis was a cross-sectional, observational study conducted from May 17, 2017, to May 31, 2019. The study included a community-based sample. Participants in the Atherosclerosis Risk in Communities study from Jackson, Mississippi (all self-reported Black participants), and Washington County, Maryland (all self-reported White participants), were recruited in the Eye Determinants of Cognition study (EyeDOC). Data analyses were conducted from June 14, 2020, to May 31, 2021. MAIN OUTCOMES AND MEASURES Retinal measurements, including retinal nerve fiber layer (RNFL) thickness, macular ganglion cell complex (GCC) thickness, macular vessel density (VD) in the superficial capillary plexus (SCP) and deep capillary plexus (DCP), and foveal avascular zone (FAZ) area, were captured with spectral-domain OCT and OCTA. Visual function, including presenting distance vision, corrected distance vision, near visual acuity (VA), and contrast sensitivity (CS), was assessed. RESULTS A total of 759 participants (mean [SD] age, 80 [4.2] years; 480 female participants [63%]; 352 Black participants [46%]) were included in the study. Mean (SD) GCC thickness (89.2 [9.3] μm vs 92.3 [8.5] μm) and mean (SD) FAZ (0.36 [0.16] mm 2 vs 0.26 [0.12] mm 2 ) differed between Jackson and Washington County participants, respectively. Mean (SD) RNFL thickness and mean (SD) VD in SCP and DCP were greater for participants 80 years or younger than for participants older than 80 years (RNFL: Յ80 years, 93.2 [10.5] μm; >80 years, 91.1 [11.6] μm; VD SCP, Յ80 years, 44.3% [3.5%]; >80 years, 43.5% [3.8%]; VD DCP, Յ80 years, 44.7% [4.9%]; >80 years, 43.7% [4.8%]). Linear regression showed each 10-μm increment in RNFL thickness and GCC thickness was positively associated with 0.016 higher logCS among all participants (RNFL: 95% CI, 0.005-0.027; P = .004; GCC: 95% CI, 0.003-0.029; P = .02), with stronger associations among Jackson participants. The associations of VA and structural measures were found only in Jackson participants, with coefficients per 10-μm increment of 0.012 logMAR VA (RNFL: 95% CI, 0.000-0.023; P = .049) and 0.020 logMAR VA (GCC: 95% CI, 0.004-0.034; P = .04). CONCLUSIONS AND RELEVANCEIn this cross-sectional study, better CS was associated with greater RNFL thickness and GCC thickness, but no visual measures were associated with angiographic features overall. These findings suggest that clinical application of normative references for OCT-and OCTA-based measures should consider demographic and community features.

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Thicker macula in asymptomatic APOE Ɛ4 middle‐aged adults at high AD risk

Rotenstreich

Sharvit‐Ginon

Sher

et al. 2022

Alz & Dem Diag Ass & Dis Mo

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Introduction We compared retinal layers’ thickness between apolipoprotein E (APOE) Ɛ4 carriers and non‐carriers in a cohort of cognitively normal middle‐aged adults enriched for Alzheimer's disease (AD) risk. Methods Participants (N = 245) underwent spectral domain optical coherence tomography. Multivariate analyses of covariance adjusting for age, sex, education, and best corrected vision acuity was used to compare retinal thickness between APOE groups. Results Participants’ mean age was 59.60 (standard deviation = 6.42) with 66.4% women and 32.2% APOE Ɛ4 carriers. Greater macular full thickness was observed in APOE Ɛ4 carriers compared to non‐carriers (P = .017), reaching statistical significance for the inner and outer nasal (P = .009 and P = .005, respectively), inner superior (P = .041), and inner and outer inferior (P = .013 and P = .033, respectively) sectors. The differences between APOE groups were mainly driven by the ganglion cell layer (P < .05) and the inner plexiform layer (P < .05). Discussion A thicker macula is observed already in midlife asymptomatic APOE Ɛ4 carriers at high AD risk.

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Visualization of Focal Thinning of the Ganglion Cell–Inner Plexiform Layer in Patients with Mild Cognitive Impairment and Alzheimer’s Disease

Abstract: Focal thinning of the GCIPL was visualized and quantified by detailed partitions in AD and MCI, which provides specific information about neurodegeneration in MCI and AD.

Cited by 50 publications

References 33 publications

Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis

Association of Optical Coherence Tomography and Optical Coherence Tomography Angiography Retinal Features With Visual Function in Older Adults

Thicker macula in asymptomatic APOE Ɛ4 middle‐aged adults at high AD risk

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