Visualization of Hepatic Uptake Transporter Function in Healthy Subjects by Using Gadoxetic Acid–enhanced MR Imaging

Nassif, Ali; Jia, Jia; Keiser, Markus; Oswald, Stefan; Modeß, Christiane; Nagel, Stefan; Weitschies, Werner; Hosten, Norbert; Siegmund, Werner; Kühn, Jens‐Peter

doi:10.1148/radiol.12112061

Cited by 129 publications

(95 citation statements)

References 36 publications

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“…Gd-EOB-DTPA is mainly incorporated into hepatocytes by organic anion transporting polypeptide (OATP) 1B3 and its uptake rate significantly correlates with OATP1B3 expression in normal hepatocytes and HCC cells [33,34]. OATP1B3 is predominantly expressed in hepatocytes distributed around zone III in normal liver parenchyma [35].…”

Section: Mri Of Rild and Focal Liver Injurymentioning

confidence: 99%

“…Radiation-induced hepatitis is described as "radiation hepatitis", "radiation-induced hepatic toxicity", "radiation-induced liver damage", and "radiation-induced liver disease (RILD)". RILD, which describes clinical and pathological features [1][2][3][4], refers to the severity of liver toxicity after high-dose radiotherapy delivered to large liver volumes or when the whole-liver tolerance dose (30)(31)(32)(33)(34)(35) is exceeded during external beam radiotherapy (RT).…”

Section: Introductionmentioning

confidence: 99%

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Pathology and images of radiation-induced hepatitis: a review article

et al. 2018

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Recent advances in highly conformal radiotherapies greatly extend the indications for radiotherapy of liver tumors. However, because of poor tolerance to hepatic radiation, estimation of the intensity of irradiation of the liver is important, particularly for a cirrhotic liver. Knowledge of radiation-induced hepatitis is important for understanding how to optimize hepatic radiation therapy. Pathological changes of the irradiated liver, which include perivenular fibrosis, sinusoidal obstruction, and damage to Kupffer cells and hepatocytes, can be visualized using clinical imaging techniques. This review article discusses and illustrates the pathological and radiological changes of hepatic tumors and the surrounding parenchyma of the irradiated liver.

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Section: Mri Of Rild and Focal Liver Injurymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pathology and images of radiation-induced hepatitis: a review article

et al. 2018

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“…The magnetic resonance imaging agent gadoliniumethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is also shown to be transported by OATP1B1 and OATP1B3 (33)(34)(35). In a retrospective study involving 22 Due to the limited number of references that can be cited in this review, Table I does not include original references, but details can be found in the recent reviews (7,8) and references therein OATP organic anion-transporting polypeptide, DHEA-S dehydroepiandrosterone sulfate, Gd-EOB-DTPA gadolinium-ethoxybenzyldiethylenetriamine pentaacetic acid patients with hepatic cancer, high OATP1B3 expression levels were significantly correlated with increased uptake of Gd-EOB-DTPA (33).…”

Section: Role Of Oatps In the Disposition Of Substra Tes Implicated Imentioning

confidence: 99%

“…In a retrospective study involving 22 Due to the limited number of references that can be cited in this review, Table I does not include original references, but details can be found in the recent reviews (7,8) and references therein OATP organic anion-transporting polypeptide, DHEA-S dehydroepiandrosterone sulfate, Gd-EOB-DTPA gadolinium-ethoxybenzyldiethylenetriamine pentaacetic acid patients with hepatic cancer, high OATP1B3 expression levels were significantly correlated with increased uptake of Gd-EOB-DTPA (33). In individuals carrying certain genetic variations associated with decreased OATP1B1 activity, the liver enhancement by the gadolinium-based imaging agent was substantially attenuated (35). These findings suggest that the activity of OATPs and genetic variations may be potential confounders leading to a reduced signal intensity in liver magnetic resonance imaging.…”

Section: Role Of Oatps In the Disposition Of Substra Tes Implicated Imentioning

confidence: 99%

Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy

Thakkar

Lockhart

Lee

2015

AAPS J

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Abstract. The superfamily of organic anion-transporting polypeptides (OATPs, gene symbol SLCO) includes important transporters handling a variety of endogenous and xenobiotic substrates. Currently, 11 human OATPs are known and their substrates include endogenous hormones and their conjugates, anticancer drugs, and imaging agents. The contribution of OATPs to the in vivo disposition of these substrates has been extensively investigated. An accumulating body of evidence also indicates that the expression of some OATPs may be up-or downregulated in several types of cancers, suggesting potential pathogenic roles during the development and progression of cancer. Given that the role of OATPs in handling cancer therapeutics has been already covered by several excellent reviews, this review will focus on the recent progresses on the topic, in particular the role of OATPs in the disposition of anticancer drugs, the impact of OATP genetic variations on the function of OATPs, and the OATPs differentially expressed in cancer and their potential roles in cancer development, progression, and treatment.

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“…It is a gadolinium chelate that is actively taken up into the hepatocytes through the organic aniontransporting polypeptides [15]. This is a property Gd-EOB-DTPA shares with the iminodiacetic acid compounds used in hepatobiliary scintigraphy (HBS) and with indocyanine green (ICG) [16][17][18][19][20].…”

mentioning

confidence: 99%