Visualization of implanted mesh in the pelvic reconstructive surgery using an X-ray-detectable thread

Li, Hui; Shu, Huimin; Qiao, Guangfang; Dai, Zhiyuan

doi:10.1007/s00404-021-06180-x

Cited by 3 publications

(1 citation statement)

References 27 publications

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“…After 180 days, rabbits were euthanised to study histocompatibility and chronic toxicity 7 and 180 Adding radiopaque barium sulphate enables mesh visibility on X-ray imaging. Novel design is non-toxic and does not affect histocompatibility Rabbits were suitable for testing toxicity and histocompatibility—no investigation for mesh efficacy China Li et al [ 3 ] Rat PP mesh with pore sizes: Abdominal wall Plain textiles investigated using textile standards (NF-EN-13494–1). Mechanical characterisation performed using cyclic uniaxial tensile tests 90 Best outcomes with lighter mesh and low stiffness.…”

Section: Resultsmentioning

confidence: 99%

The use of animal models in preclinical investigations for the development of a surgical mesh for pelvic organ prolapse

Seifalian,

Digesu,

Khullar

2024

Int Urogynecol J

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Introduction and hypothesis Polypropylene (PP) mesh for the treatment of pelvic organ prolapse (POP) has raised substantial concerns over long-term complications, leading to its ban in multiple countries. In response, emerging materials are being explored as alternatives for prolapse surgery. Preclinical animal models have historically played a pivotal role in validating medical devices, prior to clinical trials. Successful translation of these materials necessitates the identification of suitable animal models that replicate the female human pelvis and its biomechanical properties. Preclinical in vivo testing assesses the safety of surgical mesh and treatment efficacy in preventing POP recurrence. Methods The research critically reviews animal models used for preclinical pelvic mesh testing over the last decade and proposes a promising model for future preclinical studies. Results Rats were the most common mammal used for toxicity and biocompatibility investigations through abdominal implantation. Although non-human primates serve as a gold standard for efficacy testing, ethical considerations limit their use owing to their close biological and cognitive resemblance to humans. Consequently, sheep were the most preferred large animal model owing to their reproductive system similarities and propensity for spontaneous POP following parity. Conclusion The study contributes valuable insights into the selection of appropriate animal models for preclinical pelvic mesh testing, offering guidance that is crucial for enhancing the safety and efficacy of novel surgical interventions in the treatment of POP.

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