Visualization of multidirectional regional left ventricular dynamics by high‐temporal‐resolution tissue phase mapping

Föll, Daniela; Jung, Bernd; Staehle, Felix; Schilli, Elfriede; Bode, Christoph; Hennig, Jürgen; Markl, Michael

doi:10.1002/jmri.21634

Cited by 38 publications

(37 citation statements)

References 44 publications

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“…Peak diastolic velocity was observed around 0.6 ntu, which shows clear declination with age as previously described by Föll et al [12]. The trend of the velocity profile was fairly similar amongst the age groups, with the lowest radial velocities near the apex and the highest in the basal region, as anticipated by earlier studies [12,16,23]. …”

Section: Resultssupporting

confidence: 74%

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Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

et al. 2013

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Objectives: This study investigates the effect of aging on the radial viscoelastic behavior of the left ventricle (LV) based on a previously validated model that uses myocardial tissue phase mapping (TPM) of cine phase-contrast MRI. Methods: Previous studies suggest that aging remarkably influences regional myocardial motion, mostly myocardial velocities in both radial and long-axis directions. However, the effect of aging on cardiac viscoelasticity, which exhibits time-dependent strain, has not been elucidated yet. In this study, myocardial velocity and displacement mapping of the LV was performed using TPM in 39 healthy subjects divided into three age groups. The viscoelasticity parameters were obtained for each segment of the LV and compared among the studied groups. Results: The analyses showed that myocardial elasticity ranged from approximately 20 to -20 dyne/cm² during a cardiac cycle, and the myocardial viscous-damping component ranged from -1 to 1 dyne × s/cm². Overall, no statistically significant difference was observed in the viscoelasticity components among the subjects in the different age groups (p > 0.05). Conclusion: Myocardial viscoelastic behavior of the LV in radial direction was found to be considerably similar in pattern and magnitude among the studied subjects of different age groups with no statistically significant difference, despite the fact that the regional myocardial velocities change due to aging.

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Section: Resultssupporting

confidence: 74%

“…The volunteers underwent an MRI scan at the University Hospital Freiburg in Freiburg, Germany; the volunteers were part of a previously described cohort [12,16]. This study was conducted according to the institutional ethical guidelines and written informed consent was obtained from all volunteers.…”

Section: Methodsmentioning

confidence: 99%

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

et al. 2013

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“…TPM was performed in 58 healthy controls (29 men, 29 women) divided into age group 1 (20-40 years, n ¼ 19, 9 women), age group 2 (40-60 years, n ¼ 20, 11 women), and age group 3 (>60 years, n ¼ 19, 9 women). This cohort has been described previously (10,11). For the presented study a new, retrospective analysis of the data was performed.…”

Section: Study Populationmentioning

confidence: 99%

Magnetic resonance tissue phase mapping: Analysis of age‐related and pathologically altered left ventricular radial and long‐axis dyssynchrony

Föll

Jung²,

Germann

et al. 2011

Magnetic Resonance Imaging

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Purpose: To employ magnetic resonance tissue phase mapping (TPM) for the assessment of age-related left ventricular (LV) synchrony of radial and long-axis motion in healthy volunteers and in hypertensive heart disease, dilated cardiomyopathy (DCM), and left bundle branch block (LBBB).Materials and Methods: TPM (spatial/temporal resolution ¼ 1.3 Â 2.6 mm 2 /13.8 msec) was employed to measure radial and long-axis myocardial velocities in 58 healthy volunteers of three age groups and 37 patients (hypertensive, n ¼ 18; DCM, n ¼ 12; DCM and LBBB n ¼ 7). Regional times-to-peak velocities (TTP) in systole and diastole were derived for all LV segments. Four measures of dyssynchrony were defined as the standard deviation of systolic and diastolic TTP for radial and long-axis motion.Results: Systolic radial and diastolic long-axis dyssynchrony was increased (P < 0.01) in all patient groups compared to controls. Multiple regressions revealed a significant relationship of dyssynchrony with LV ejection fraction and mass for systolic radial (P < 0.001 resp. P ¼ 0.02), diastolic radial (P < 0.001 resp. P < 0.05), and long-axis (P < 0.001 resp. P ¼ 0.001) motion. Diastolic dyssynchrony correlated with the LV remodeling index (P < 0.05) and increased with age (P < 0.03). Systolic long-axis dyssynchrony was not influenced by disease or LV function. Conclusion:Radial systolic and long-axis diastolic dyssynchrony were the most sensitive markers for altered dyssynchrony in hypertensive heart disease or DCM. Future studies are needed to evaluate the diagnostic value of TPM-derived dyssynchrony parameters.

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“…In an initial study with the same study population, we could recently show that TPM enables a complete visualization of LV motion and that a correlation analysis of the data might be useful to detect local differences of myocardial velocities. 14 The aim of this study is to analyze myocardial motion on a segmental basis to define the influence of age and gender on LV performance in healthy volunteers. For clinical application, it is essential to develop an understanding of the distribution and dynamics of normal myocardial velocities.…”

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Magnetic Resonance Tissue Phase Mapping of Myocardial Motion

Föll

Jung

Schilli

et al. 2010

Circ: Cardiovascular Imaging

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Background-An exact understanding of normal age-and gender-matched regional myocardial performance is an essential perquisite for the diagnosis of heart disease. Magnetic resonance phase-contrast imaging (tissue phase mapping) enabling the analysis of segmental, 3-directional myocardial velocities with high temporal resolution (13.8 ms) was used to assess left ventricular motion. Methods and Results-Radial, long-axis, and rotational myocardial velocities were acquired in 58 healthy volunteers (3 age groups, 29 women) in left ventricular basal, midventricular, and apical short-axis locations. For increased age, reduced (PϽ0.003) and prolonged long-axis and radial velocities (PϽ0.05) during diastole and reduced long-axis velocities (PϽ0.001) and apical rotation (PϽ0.005) during systole were found for both genders. Women demonstrated a reduced systolic twist (Pϭ0.009), apical rotation (Pϭ0.01), and systolic radial velocities (PϽ0.02) compared with men. Segmental analysis of long-axis motion with aging revealed differences in regional reduction of systolic (lateral 52% versus 30%) and diastolic (lateral 57% versus 41%) velocities in women compared with men. In basal segments, young women demonstrated higher long-axis velocities (ϩ11% during diastole) than men, whereas this difference was reversed in older subjects (same segments, Ϫ20%). In addition, increased age resulted in a prolonged time to peak diastolic apical rotation (PϽ0.04) in women compared with men. Conclusions-Age and gender strongly influence regional myocardial motion. Tissue phase mapping provides a comprehensive quantitative analysis of all myocardial velocities with high temporal and spatial resolution. The knowledge of the detected ageand gender-related differences in myocardial motion is fundamental for further investigations of cardiac disease. Clinical Trial Registration-http://www.zks.uni-freiburg.de/uklreg/php/suchergebnis_all.php. Identifier: UKF001739(Circ Cardiovasc Imaging. 2010;3:54-64.)Key Words: magnetic resonance imaging Ⅲ myocardial contraction Ⅲ aging Ⅲ gender V olumetric analysis of the left ventricle based on MRI has been established as a reference standard for the determination of left ventricular (LV) performance. 1 However, early changes in LV motion and regional pathologies may be overlooked by these global parameters because they do not reflect diastolic function or segmental contractility, which are not uniform within the healthy LV. 2 Therefore, a complete segmental analysis of velocities is preferable to detect subtle changes in LV motion. 3 Quantitative noninvasive assessment of regional myocardial performance still remains challenging. 4 Myocardial velocities and derived parameters mainly based on tissue Doppler imaging were suggested as markers for LV contractility 5 and diastolic function. 4 However, because tissue Doppler velocity analyses do not allow assessing all myocardial velocity components, ie, radial, long-axis, and rotational motion for the different LV regions, MRI applications have been developed as alterna...

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Visualization of multidirectional regional left ventricular dynamics by high‐temporal‐resolution tissue phase mapping

Cited by 38 publications

References 44 publications

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

Aging Does Not Affect Radial Viscoelastic Behavior of the Left Ventricle

Magnetic resonance tissue phase mapping: Analysis of age‐related and pathologically altered left ventricular radial and long‐axis dyssynchrony

Magnetic Resonance Tissue Phase Mapping of Myocardial Motion

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